tripropylene glycol-di-p-tosylate | 175082-11-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tripropylene glycol-di-p-tosylate
• 英文别名: 2-[2-[2-(4-Methylphenyl)sulfonyloxypropoxy]propoxy]propyl 4-methylbenzenesulfonate
• CAS: 175082-11-8
• 化学式: C₂₃H₃₂O₈S₂
• 分子量: 500.634
• InChiKey: QYEWWDZRUSDZPS-UHFFFAOYSA-N

物化性质

• 沸点：
  620.4±55.0 °C(Predicted)
• 密度：
  1.225±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  33
• 可旋转键数：
  13
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  122
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  2-二甲氨基吡啶 、 三丙二醇 、 对甲苯磺酰氯 在 三乙胺 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 以19.2%的产率得到tripropylene glycol-di-p-tosylate
  参考文献：
  名称：

  Compositions of iodophenoxy alkylene ethers and pharmaceutically

  摘要：

  本发明揭示了用于口服或逆行检查消化道的X射线造影剂，包括碘苯氧烷醚和药用可接受的粘土在药用可接受的载体中的组合物；以及它们在消化道诊断放射学中的使用方法。

  公开号：

  US05492687A1

文献信息

• Compositions of iodophenoxy alkylene ethers in film-forming materials
  申请人：Sterling Winthrop Inc.

  公开号：US05310538A1

  公开（公告）日：1994-05-10

  ##STR1## wherein Z=H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R=C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl, each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 =CR.sub.4).sub.m Q ,or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; R.sub.1, R.sub.2 and R.sub.3 and R.sub.4 are independently H, or lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-4; m is 1-15; p is 1-20; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl These compounds are combined in a polymer for use as an X-ray contrast agent.

  其中 Z=H，卤素，C.sub.1 -C.sub.20 烷基，环烷基，低烷氧基，烷氧羰基，氰基，其中烷基和环烷基基团可被卤素或卤素-低烷基基团取代；R=C.sub.1 -C.sub.25 烷基，环烷基，或卤素-低烷基，每个基团均可选择地被卤素，氟-低烷基，芳基，低烷氧基，羟基，羧基，低烷氧羰基或低烷氧羰氧基取代，(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 =CR.sub.4).sub.m Q，或 (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q；R.sub.1，R.sub.2，R.sub.3 和 R.sub.4 独立地为 H，或低烷基，可选择地被卤素取代；x 为 1-4；n 为 1-4；m 为 1-15；p 为 1-20；Q 为 H，低烷基，低烯基，低炔基，低烷基烯，芳基，或芳基-低烷基。这些化合物被组合在聚合物中用作X射线造影剂。
• Compositions of iodophenoxy alkylene ethers and cellulose derivatives
  申请人：Sterling Winthrop Inc.

  公开号：US05466435A1

  公开（公告）日：1995-11-14

  Disclosed are contrast agents of the formula ##STR1## wherein Z is H, halo, C.sub.1 -C.sub.20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R is C.sub.1 -C.sub.25 alkyl, cycloalkyl, ##STR2## or halo-lower-alkyl; each of which may be optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy; (CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q, or (CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q; R.sub.1, R.sub.2, R.sub.3 and R.sub.4 are independently H or lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-4; m is 1-15; p is 1-20; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl; in an aqueous, pharmaceutically acceptable carrier comprising a cellulose derivative.

  揭示了以下公式的对比剂##STR1## 其中Z为H、卤素、C.sub.1 -C.sub.20烷基、环烷基、较低的烷氧基、烷氧羰基、氰基，其中烷基和环烷基基团可以被卤素或卤素-较低烷基基团取代；R为C.sub.1 -C.sub.25烷基、环烷基、##STR2## 或卤素-较低烷基；每个都可以选择性地被卤素、氟-较低烷基、芳基、较低烷氧基、羟基、羧基、较低烷氧基羰基或较低烷氧基-羰氧基取代；(CR.sub.1 R.sub.2).sub.p --(CR.sub.3 .dbd.CR.sub.4).sub.m Q，或(CR.sub.1 R.sub.2).sub.p --C.tbd.C--Q；R.sub.1、R.sub.2、R.sub.3和R.sub.4独立地为H或较低烷基，可以选择性地被卤素取代；x为1-4；n为1-4；m为1-15；p为1-20；Q为H、较低烷基、较低烯烃基、较低炔烃基、较低烷基烯、芳基或芳基-较低烷基；在含有纤维素衍生物的水性、药学上可接受的载体中。
• Coating varnish composition and antifouling coating composition
  申请人：HITACHI CHEMICAL CO., LTD.

  公开号：EP0608132A1

  公开（公告）日：1994-07-27

  The invention provides a coating varnish composition comprising (A) a polymer obtained by polymerizing (a) at least one unsaturated acid anhydride and (b) at least one other unsaturated monomer, and (B) at least one additive selected from triazole derivatives, benzothiazole derivatives, thiadiazole derivatives, polyethers and carboxylic acid anhydride derivatives and an antifouling coating composition comprising said coating varnish and an antifouling agent containing a coppercompound as major component. Using such compositions the risks of poisoning associated with organotin copolymers are avoided and there are obtained coatings of a coating consuming property and antifouling performance comparable with those of the organotin copolymers which do not gel even when mixed with a copper compound.

  本发明提供了一种涂料清漆组合物，该组合物包含(A)通过聚合(a)至少一种不饱和酸酐和(b)至少一种其他不饱和单体而得到的聚合物，和(B)至少一种选自三唑衍生物、苯并噻唑衍生物、噻二唑衍生物、聚醚和羧酸酐衍生物的添加剂，以及一种防污涂料组合物，该组合物包含上述涂料清漆和一种以铜化合物为主要成分的防污剂。使用这种组合物可以避免与有机锡共聚物有关的中毒风险，并获得涂层消耗特性和防污性能与有机锡共聚物相当的涂层，即使与铜化合物混合也不会凝胶。
• Compositions of iodophenoxy alkylene ethers in film-formin materials for visualization of the gastrointestinal tract
  申请人：NYCOMED IMAGING AS

  公开号：EP0614670A2

  公开（公告）日：1994-09-14

  Disclosed are x-ray contrast compositions for oral or retrograde examination of the GI tract comprising a polymeric material capable of forming a coating on the GI tract, said polymeric material having atoms containing polarizable electrons thereon, in combination with a divalent cation: and an x-ray contrast producing agent of the formula wherein Z = H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = C1-C25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, Ri, R2, R3 and R4 are independently H, lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-20; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl; in a pharmaceutically acceptable carrier and a method of its use in diagnostic radiology of the GI tract.

  本发明公开了用于消化道口腔或逆行检查的 X 射线造影剂组合物，该组合物包含一种可在消化道上形成涂层的聚合材料，所述聚合材料上有含有可极化电子的原子，该聚合材料与二价阳离子结合：以及一种X射线造影剂，其式为 其中 Z = H、卤素、C1-C20 烷基、环烷基、低级烷氧基、烷氧羰基、氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代； R = C1-C25 烷基、环烷基或卤代低烷基，可任选被卤、氟代低烷基、芳基、低烷氧基、羟基、羧基、低烷氧基羰基或低烷氧基羰氧基取代、 Ri、R2、R3 和 R4 独立地为 H、低级烷基，可选择被卤素取代； x 为 1-4； n 为 1-5 m 是 1-15； p 是 1-20；以及 Q 是 H、低级烷基、低级烯基、低级炔基、低级亚烷基、芳基或芳基-低级烷基。
• Compositions of iodophenoxy alkylene ethers for visualization of the gastrointestinal tract
  申请人：NYCOMED IMAGING AS

  公开号：EP0619121A2

  公开（公告）日：1994-10-12

  Disclosed are contrast agents of the formula or a pharmaceutically acceptable salt thereof, contained in aqueous compositions and methods for their use in diagnostic radiology of the gastrointestinal tract wherein Z = H, halo, C1-C20 alkyl, cycloalkyl, lower alkoxy, alkoxycarbonyl, cyano, where the alkyl and cycloalkyl groups can be substituted with halogen or halo-lower-alkyl groups; R = Cl-C25 alkyl, cycloalkyl, or halo-lower-alkyl, optionally substituted with halo, fluoro-lower-alkyl, aryl, lower-alkoxy, hydroxy, carboxy, lower-alkoxy carbonyl or lower-alkoxy-carbonyloxy, (CR1 R2)ρ-(CR3 = CR4)mQ, or (CR1 R2)p-C=C-Q; Ri, R2, R3 and R4 are independently H, lower-alkyl, optionally substituted with halo; x is 1-4; n is 1-5; m is 1-15; p is 1-20; and Q is H, lower-alkyl, lower-alkenyl, lower-alkynyl, lower-alkylene, aryl, or aryl-lower alkyl. in an aqueous, pharmaceutically acceptable carrier.

  公开了式 或其药学上可接受的盐，包含在水性组合物中，以及将其用于胃肠道放射诊断的方法，其中 Z = H、卤素、C1-C20 烷基、环烷基、低级烷氧基、烷氧羰基、氰基，其中烷基和环烷基可被卤素或卤代低级烷基取代； R = Cl-C25 烷基、环烷基或卤代低烷基，可任选被卤、氟代低烷基、芳基、低烷氧基、羟基、羧基、低烷氧基羰基或低烷氧基羰氧基、(CR1 R2)ρ-(CR3 = Ri、R2、R3 和 R4 独立地为 H、低级烷基，可选被卤素取代；x 为 1-4；n 为 1-5；m 为 1-15；p 为 1-20；Q 为 H、低级烷基、低级烯基、低级炔基、低级亚烷基、芳基或芳基-低级烷基。