potassium p-methylphenylacetate | 42766-35-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: potassium p-methylphenylacetate
• 英文别名: potassium p-tolylacetate；Potassium;2-(4-methylphenyl)acetate
• CAS: 42766-35-8
• 化学式: C₉H₉O₂*K
• 分子量: 188.268
• InChiKey: FDJJMQRIEWTAQS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  -2.71
• 重原子数：
  12
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  40.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  potassium p-methylphenylacetate 在 N-溴代丁二酰亚胺(NBS) 、 乙酸酐 、 过氧化苯甲酰 作用下， 以 四氯化碳 为溶剂， 反应 12.0h， 生成 3-[4-(bromomethyl)phenyl]-6,7-dimethoxy-2H-2-chromenone
  参考文献：
  名称：

  Extensive SAR and Computational Studies of 3-{4-[(Benzylmethylamino)methyl]phenyl}-6,7-dimethoxy-2H-2-chromenone (AP2238) Derivatives

  摘要：

  AP2238 was the first compound published to bind both anionic sites of the human acetylcholinesterase, allowing the simultaneous inhibition of the catalytic and the amyloid-beta pro-aggregating activities of AChE. Here we attempted to derive a comprehensive structure-activity relationship picture for this molecule, affording 28 derivatives for which AChE and BChE inhibitory activities were evaluated. Selected compounds were also tested for their ability to prevent the AChE-induced A beta-aggregation. Moreover, docking simulations and molecular orbital calculations were performed.

  DOI：

  10.1021/jm070100g
• 作为产物：
  描述：

  对甲基苯乙酸 、 氢氧化钾 生成 potassium p-methylphenylacetate
  参考文献：
  名称：

  MANOLOV, I.;KARAIVANOVA, M. H.

  摘要：

  DOI：

文献信息

• Continuous Flow Photochemical and Thermal Multi-Step Synthesis of Bioactive 3-Arylmethylene-2,3-Dihydro-1H-Isoindolin-1-Ones
  作者：Saira Mumtaz、Mark J. Robertson、Michael Oelgemöller

  DOI：10.3390/molecules24244527

  日期：——

  An effective multi-step continuous flow approach towards N-diaminoalkylated 3-arylmethylene-2,3-dihydro-1H-isoindolin-1-ones, including the local anesthetic compound AL-12, has been realized. Compared to the traditional decoupled batch processes, the combined photochemical–thermal–thermal flow setup rapidly provides the desired target compounds in superior yields and significantly shorter reaction

  一种针对 N-二氨基烷基化 3-芳基亚甲基-2,3-dihydro-1H-isoindolin-1-ones 的有效多步连续流动方法，包括局部麻醉化合物 AL-12，已经实现。与传统的分批分离工艺相比，组合的光化学-热-热流动设置以优异的产率和显着更短的反应时间快速提供所需的目标化合物。
• Photodecarboxylative Benzylations of N-Methoxyphthalimide under Batch and Continuous-Flow Conditions
  作者：Hossein Mohammadkhani Pordanjani、Christian Faderl、Jun Wang、Cherie A. Motti、Peter C. Junk、Michael Oelgemöller

  DOI：10.1071/ch15356

  日期：——

  A series of photodecarboxylative benzylations of N-methoxyphthalimide were successfully realised using easily accessible starting materials. The reactions proceeded smoothly and the corresponding benzylated hydroxyphthalimidines were obtained in moderate to good yields of 52–73 %. No competing photoinduced dealkoxylation of the N-methoxy group was observed. The reaction with potassium phenylacetate was subsequently investigated in an advanced continuous-flow photoreactor. The reactor allowed rapid optimization of the reaction conditions and gave the desired benzylated product in higher yield and shorter irradiation time compared with the batch process.

  利用容易获得的起始材料，成功实现了一系列 N-甲氧基邻苯二甲酰亚胺的光致十二羧基苄基化反应。反应顺利进行，并获得了相应的苄基羟基邻苯二甲酰亚胺，收率从中等到良好，为 52-73%。没有观察到 N-甲氧基发生竞争性光诱导脱烷氧基化反应。与苯乙酸钾的反应随后在先进的连续流光反应器中进行了研究。与间歇式工艺相比，该反应器可以快速优化反应条件，并以更高的产率和更短的辐照时间得到所需的苄基化产物。
• Polyphenylene sulfide resin compositions
  申请人：Kojima Akira

  公开号：US20070021549A1

  公开（公告）日：2007-01-25

  A polyphenylene sulfide resin composition which comprises 100 parts by weight of a polyphenylene sulfide resin (A) and, compounded therewith, 1 to 100 parts by weight of glass fibers (B) having a single-fiber diameter of 12 μm or lager and has a crystallization temperature during cooling of 205° C. or lower. Also provided is a polyphenylene sulfide resin composition which comprises 100 parts by weight of a polyphenylene sulfide resin (A) and, compounded therewith, 1 to 100 parts by weight of glass fibers (B) having a single-fiber diameter of 10 to 12 μm, excluding 12 μm, has a crystallization temperature during cooling of 205° C. or lower and a chloroform-extractable content of 0.5 wt. % or lower, and gives a 2 mm-thick molded product which has a transmittance of 15% or higher for laser beam having a wavelength of 940 nm and a heat distortion temperature of 230° C. or higher under a load of 1.82 MPa.

  一种聚苯硫醚树脂组合物，包括100重量份的聚苯硫醚树脂（A），并与之混合1至100重量份的玻璃纤维（B），其单纤维直径为12μm或更大，并在冷却时具有205℃或更低的结晶温度。另外，还提供一种聚苯硫醚树脂组合物，包括100重量份的聚苯硫醚树脂（A），并与之混合1至100重量份的玻璃纤维（B），其单纤维直径为10至12μm，不包括12μm，并在冷却时具有205℃或更低的结晶温度，氯仿可提取物含量为0.5重量％或更低，并且在1.82 MPa的负载下具有940 nm波长的激光束的透射率为15％或更高，以及230℃或更高的热变形温度的2毫米厚模制品。
• Process for the production of aromatic sulfide/sulfone polymers
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0033906A1

  公开（公告）日：1981-08-19

  Aromatic sulfide/sulfone polymers are prepared by initially contacting a dihaloaromatic sulfone, an alkali metal sulfide, an organic amide, and, optionally, an alkali metal carboxylate under polymerization conditions and subsequently at or near completion of the polymerization reaction, adding an end-capping agent comprising additional dihaloaromatic sulfone to the reaction mixture producing a polymer exhibiting improved physical properties including melt flow stability. The resulting polymers have utility as coatings, films, molded objects, filaments, fibers, and the like.

  芳香族硫化物/砜聚合物的制备方法是：在聚合条件下，先将二卤代芳香族砜、碱金属硫化物、有机酰胺和（可选）碱金属羧酸盐接触，然后在聚合反应完成或接近完成时，向反应混合物中加入由额外的二卤代芳香族砜组成的末端封端剂，从而产生一种具有更佳物理性能（包括熔体流动稳定性）的聚合物。这种聚合物可用作涂层、薄膜、模制件、长丝、纤维等。
• Arylene sulfide polymer preparation
  申请人：PHILLIPS PETROLEUM COMPANY

  公开号：EP0086486A1

  公开（公告）日：1983-08-24

  A method for producing arylene sulfide polymer in which a reaction mixture containing at least one polyhalo-substituted aromatic compound, at least one organic amide, at least one alkali metal carboxylate, H2S and water in an amount up to 5 weight percent of the total of the reaction mixture components is contacted at polymerization conditions for a time sufficient to produce polymer. In a preferred embodiment, at least one alkali metal carboxylate is present in the reaction mixture.

  一种生产芳基硫醚聚合物的方法，将含有至少一种多卤代芳香族化合物、至少一种有机酰胺、至少一种碱金属羧酸盐、H2S 和水的反应混合物（用量不超过反应混合物组分总量的 5 重量％）在聚合条件下接触足够长的时间以生产聚合物。在一个优选的实施方案中，反应混合物中至少含有一种碱金属羧酸盐。