2,2'-Diphenetol | 7168-53-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,2'-Diphenetol
• 英文别名: 2,2'-Diethoxybiphenyl；1-ethoxy-2-(2-ethoxyphenyl)benzene
• CAS: 7168-53-8
• 化学式: C₁₆H₁₈O₂
• 分子量: 242.318
• InChiKey: VBRABAVDCNSSSA-UHFFFAOYSA-N

物化性质

• 沸点：
  310.4±17.0 °C(Predicted)
• 密度：
  1.027±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2,2'-Diphenetol 在 硝酸 作用下， 生成 1,3,6,8-四硝基-9-苯基咔唑
  参考文献：
  名称：

  van Alphen, Recueil des Travaux Chimiques des Pays-Bas, 1932, vol. 51, p. 179,181

  摘要：

  DOI：
• 作为产物：
  描述：

  alkaline earth salt of/the/ methylsulfuric acid 在 溴乙烷 作用下， 生成 2,2'-Diphenetol
  参考文献：
  名称：

  Factors Determining the Course and Mechanisms of Grignard Reactions. IV. The Effect of Metallic Halides on the Reaction of Aryl Grignard Reagents and Organic Halides¹

  摘要：

  DOI：

  10.1021/ja01854a006

文献信息

• Catalyst‐Free Synthesis of O‐Heteroacenes by Ladderization of Fluorinated Oligophenylenes
  作者：Mikhail Feofanov、Vladimir Akhmetov、Ryo Takayama、Konstantin Amsharov

  DOI：10.1002/anie.202007427

  日期：2021.3

  substitution even in the presence of strong electron‐donating groups and enables de‐tert‐butylation required for the complete annulation. Also demonstrated is the applicability of the method to introduce five‐, six‐, and seven‐membered rings containing oxygen, whereas multiple annulations also open up a short synthetic path to ladder‐type O‐heteroacenes and oligodibenzofurans.

  报道了一种新颖的无催化剂方法，用于从氟化低聚亚苯基制得苯并环氧基的含氧杂环。与现有方法不同，本发明的反应不需要含氧的前体，而是依赖于外部氧源叔丁醇钾，它可作为O 2−合成子。该反应的自由基性质即使在存在强供电子基团的情况下也能促进亲核取代，并能实现完全环化所需的叔丁基化。还证明了该方法适用于引入含氧的五元，六元和七元环，而多次环化也为阶梯型邻杂并苯和低聚二苯并呋喃开辟了一条短的合成途径。
• METHOD FOR MANUFACTURING CONJUGATED AROMATIC COMPOUND
  申请人：Oda Seiji

  公开号：US20110275859A1

  公开（公告）日：2011-11-10

  A method for manufacturing a conjugated aromatic compound comprising reacting an aromatic compound (A) wherein one or two leaving groups selected from the group consisting of an iodine atom, a bromine atom and a chlorine atom are bonded to an aromatic ring and the aromatic compound (A) does not have (c1) a group represented by the following formula (10): wherein A 1 represents a C1-C20 alkoxy group etc.; (g1) a C1-C20 alkyl group which may be substituted with a fluorine atom etc.; and (h1) a C2-C20 acyl group which may be substituted with a fluorine atom etc., at the neighboring carbon atom to the carbon atom to which the leaving group is bonded, with an aromatic compound (A) having the same structure as that of the above-mentioned aromatic compound (A) or an aromatic compound (B) wherein the aromatic compound (B) is structurally different from the above-mentioned aromatic compound (A), one or two leaving groups selected from the group consisting of an iodine atom, a bromine atom and a chlorine atom are bonded to an aromatic ring and the aromatic compound (B) does not have the above-mentioned (c1), (g1) and (h1) at the neighboring carbon atom to the carbon atom to which the leaving group is bonded, in the presence of (i) a nickel compound, (ii) a metal reducing agent, (iii) at least one ligand (L1) selected from the group consisting of a 2,2′-bipyridine compound having at least one electron-withdrawing group and having no substituent at 3-, 6-, 3′- and 6′-positions, and a 1,10-phenanthroline compound having at least one electron-withdrawing group and having no substituent at 2- and 9-positions, and (iv) at least one ligand (L2) selected from the group consisting of a 2,2′-bipyridine compound having at least one electron-releasing group and having no substituent at 3-, 6-, 3′- and 6′-positions, and a 1,10-phenanthroline compound having at least one electron-releasing group and having no substituent at 2- and 9-positions.

  一种制备共轭芳香化合物的方法，包括将含有一个或两个离去基团的芳香化合物（A）与含有相同结构的上述芳香化合物（A）或结构不同的芳香化合物（B）反应，其中这些离去基团选自碘原子、溴原子和氯原子，与芳香环结合，而芳香化合物（A）没有以下式（10）所代表的基团：其中A1代表C1-C20烷氧基等；（g1）代表C1-C20烷基基团，可能被氟原子等取代；以及（h1）代表C2-C20酰基基团，可能被氟原子等取代，与离去基团结合的碳原子的相邻碳原子处没有上述（c1）、（g1）和（h1），在（i）镍化合物、（ii）金属还原剂、（iii）从2,2′-联吡啶化合物和1,10-邻菲啰啉化合物中选择的至少一种配体（L1），具有至少一个吸电子基团且在3-、6-、3′-和6′-位置没有取代基，以及（iv）从2,2′-联吡啶化合物和1,10-邻菲啰啉化合物中选择的至少一种配体（L2），具有至少一个释电子基团且在3-、6-、3′-和6′-位置没有取代基团的情况下，在上述离去基团结合的碳原子的相邻碳原子处进行反应。
• CXCR3 antagonists
  申请人：Tularik Inc.

  公开号：US20020169159A1

  公开（公告）日：2002-11-14

  Compounds, compositions and methods that are useful in the treatment of inflammatory and immune conditions and diseases are provided herein. In particular, the invention provides compounds which modulate the expression and/or function of a chemokine receptor. The subject methods are useful for the treatment of inflammatory and immunoregulatory disorders and diseases, such as multiple sclerosis, rheumatoid arthritis and type I diabetes.

  本文提供了在治疗炎症和免疫状况及疾病中有用的化合物、组合物和方法。具体来说，本发明提供了调节趋化因子受体的表达和/或功能的化合物。所述方法适用于治疗炎症和免疫调节性疾病，如多发性硬化症、类风湿关节炎和I型糖尿病。
• 2,2′-Biphen[n]arenes (n = 4–8): one-step, high-yield synthesis, and host–guest properties
  作者：Lu Dai、Zhi-Jun Ding、Lei Cui、Jian Li、Xueshun Jia、Chunju Li

  DOI：10.1039/c7cc06767d

  日期：——

  A new family of biphen[n]arenes (n = 4–8) with 2,2′-disubstituents (2,2′-BPns) has been designed and synthesized. The host–guest properties of the 2,2′-BPns have been examined; they exhibit strong binding affinities towards selected organic cationic guests.

  设计并合成了具有2,2'-取代基（2,2'-BP n s）的联苯[ n ]芳烃（n = 4-8）的新家族。已经检查了2,2'-BP n s的宿主-客体性质；它们对选定的有机阳离子客体具有很强的结合亲和力。
• MICROSTRUCTURED OPTICAL FILMS COMPRISING BIPHENYL DIFUNCTIONAL MONOMERS
  申请人：Invie Judith M.

  公开号：US20080221291A1

  公开（公告）日：2008-09-11

  Optical films having a polymerized microstructured surface are described. The polymerized microstructured surface comprises the reaction product of a polymerizable resin composition comprising 10% to 100 wt-% of at least one biphenyl di(meth)acrylate monomer. The di(meth)acrylate monomer comprises a core biphenyl structure having two aromatic rings connected with a C—C bond. The biphenyl di(meth)acrylate monomer preferably comprises a sufficient amount of ortho and/or meta(meth)acrylate substituents such that the monomer is a liquid at 25° C.

  描述了具有聚合微结构表面的光学薄膜。聚合微结构表面包括聚合物化可树脂组合物的反应产物，该组合物包括10%至100重量％的至少一种联苯二（甲基）丙烯酸酯单体。二（甲基）丙烯酸酯单体包括一个核心联苯结构，其中两个芳香环通过C-C键连接。联苯二（甲基）丙烯酸酯单体优选包括足够量的邻位和/或间位（甲基）丙烯酸酯取代基，使单体在25°C时为液体。