1-(2-Hydroxypyrrolidin-1-yl)-2,2-dimethylpropan-1-one | 145458-63-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: 1-(2-Hydroxypyrrolidin-1-yl)-2,2-dimethylpropan-1-one
• CAS: 145458-63-5
• 化学式: C₉H₁₇NO₂
• 分子量: 171.239
• InChiKey: VWYPFBVNLCTKQG-UHFFFAOYSA-N

物化性质

• 沸点：
  303.7±35.0 °C(Predicted)
• 密度：
  1.086±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.89
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  三甲基乙酰氯 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 生成 1-(2-Hydroxypyrrolidin-1-yl)-2,2-dimethylpropan-1-one
  参考文献：
  名称：

  Reductive routes to rigid peptide building blocks: The dependence of a regioselective imide reduction on the nature of an α-alkoxy substituent

  摘要：

  The reduction of several N-acylpyrrolidinones has been studied. The regioselectivity of the reductions was found to depend on the nature of the N-acyl group. In one example, the use of a sterically bulky triisopropylsiloxy substituent alpha to the N-acyl carbonyl led to exclusive reduction of the pyrrolidinone carbonyl and the formation of a product that could be used in the synthesis of the 1-azabicyclo[5.3.0]decane ring skeleton found in a key bicyclic Pro-Phe building block.

  DOI：

  10.1016/s0040-4039(00)60001-1

文献信息

• US7897601B2
  申请人：——

  公开号：US7897601B2

  公开（公告）日：2011-03-01
• Reductive routes to rigid peptide building blocks: The dependence of a regioselective imide reduction on the nature of an α-alkoxy substituent
  作者：Kevin D. Moeller、Cathleen E. Hanau

  DOI：10.1016/s0040-4039(00)60001-1

  日期：1992.10

  The reduction of several N-acylpyrrolidinones has been studied. The regioselectivity of the reductions was found to depend on the nature of the N-acyl group. In one example, the use of a sterically bulky triisopropylsiloxy substituent alpha to the N-acyl carbonyl led to exclusive reduction of the pyrrolidinone carbonyl and the formation of a product that could be used in the synthesis of the 1-azabicyclo[5.3.0]decane ring skeleton found in a key bicyclic Pro-Phe building block.