thymidine-5'-tetraphosphate | 10003-95-9

• 分子结构分类: 有机化合物 - 核苷、核苷酸和类似物 - 嘧啶核苷酸
• 英文名称: thymidine-5'-tetraphosphate
• 英文别名: 5'-O-{Hydroxy[(hydroxy{[hydroxy(phosphonooxy)phosphoryl]oxy}phosphoryl)oxy]phosphoryl}thymidine；[hydroxy-[hydroxy-[[(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy]phosphoryl]oxyphosphoryl] phosphono hydrogen phosphate
• CAS: 10003-95-9
• 化学式: C₁₀H₁₈N₂O₁₇P₄
• 分子量: 562.151
• InChiKey: KXJSIJGTZXYYNM-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.1
• 重原子数：
  33
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  285
• 氢给体数：
  7
• 氢受体数：
  17

文献信息

• Fluorescent nucleotide analogs and uses therefor
  申请人：Xu Yue

  公开号：US20070072196A1

  公开（公告）日：2007-03-29

  Labeled nucleotide analogs used in place of naturally occurring nucleoside triphosphates or other analogs in template directed nucleic acid synthesis reactions and other nucleic acid reactions, and various analyses based thereon, including DNA sequencing, single base identification, hybridization assays and others.

  在模板定向的核酸合成反应和其他核酸反应以及基于此的各种分析中，使用标记核苷酸模拟物代替自然存在的核苷三磷酸或其他类似物，包括DNA测序、单碱基识别、杂交检测等。
• Method for treating or preventing inflammatory diseases
  申请人：——

  公开号：US20030125299A1

  公开（公告）日：2003-07-03

  The present invention provides a method of preventing or treating an inflammatory disease, including but not limited to, sinusitis, rhinitis, conjunctivitis, asthma, dermatitis, inflammatory bowel disease, inflammatory collagen vascular diseases, glomerulonephritis, inflammatory skin diseases, and sarcoidosis. The method comprises administrating to a subject a pharmaceutical formulation comprising a nucleotide receptor agonist, such as nucleoside diphosphate, nucleoside triphosphate, or dinucleoside polyphosphate, according to general formula Ia, Ib, IIa, IIb, or III. Preferred indications of the present invention are perennial allergic rhinitis, seasonal allergic rhinitis, infectious allergic rhinitis, and allergic conjunctivitis.

  本发明提供了一种预防或治疗炎症性疾病的方法，包括但不限于鼻窦炎、鼻炎、结膜炎、哮喘、皮炎、炎症性肠病、炎症性胶原血管病、肾小球肾炎、炎症性皮肤病和肉瘤病。该方法包括向受试者施用包含核苷酸受体激动剂的药物制剂，例如二磷酸核苷、三磷酸核苷或多磷酸二核苷，根据通式 Ia、Ib、IIa、IIb 或 III。本发明的优选适应症是常年性过敏性鼻炎、季节性过敏性鼻炎、感染性过敏性鼻炎和过敏性结膜炎。
• TARGETED LIPOSOMAL CONSTRUCTS FOR DIAGNOSTIC AND THERAPEUTIC USES
  申请人：SDG, INC.

  公开号：EP1005327A1

  公开（公告）日：2000-06-07
• EP1450820A4
  申请人：——

  公开号：EP1450820A4

  公开（公告）日：2009-02-18
• METHOD FOR TREATING OR PREVENTING INFLAMMATORY DISEASES
  申请人：Inspire Pharmaceuticals, Inc.

  公开号：EP1450820A2

  公开（公告）日：2004-09-01