3-Thia-15-heptadecyne | 873944-58-2

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 3-Thia-15-heptadecyne
• 英文别名: 14-(Ethylsulfanyl)tetradec-2-yne；14-ethylsulfanyltetradec-2-yne
• CAS: 873944-58-2
• 化学式: C₁₆H₃₀S
• 分子量: 254.48
• InChiKey: VZNVUJNOJIDOAP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.88
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  14-bromotetradec-2-yne 、 巯基乙酸 在 盐酸 、 氢氧化钾 作用下， 以 甲醇 、 氯仿 为溶剂， 生成 3-Thia-15-heptadecyne
  参考文献：
  名称：

  NOVEL FATTY ACID ANALOGOUS

  摘要：

  公开号：

  EP1265838B9

文献信息

• NATURAL LIPIDS CONTAINING NON-OXIDIZABLE FATTY ACIDS
  申请人：LIFE SCIENCE NUTRITION AS

  公开号：US20160024125A1

  公开（公告）日：2016-01-28

  Provided herein is technology relating to natural lipids containing non-β-oxidizable fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of natural lipids containing non-β-oxidizable fatty acids.

  本技术涉及含有非β氧化脂肪酸的天然脂类，特别是但不限于与含有非β氧化脂肪酸的天然脂类的组合物和方法相关的生产和使用。
• Novel fatty acids analogous
  申请人：——

  公开号：US20040213442A1

  公开（公告）日：2004-10-28

  The present invention relates to novel fatty acid analogous of the general formula (I): R 1 —[x i —CH 2 ] n —COOR 2 wherein R 1 is: a C 6 -C 24 alkene with one or more double bonds and/or with one or more triple bonds, and/or a C 6 -C 24 alkyne, and/or a C 6 -C 24 alkyl substituted in one or several positions with one or more compounds selected from the group comprising fluoride, chloride, hydroxy. C 1 -C 4 alkoxy, C 1 -C 4 alkylthio, C 2 -C 5 acyloxy or C 1 -C 4 alkyl, and wherein R2 represents hydrogen or C 1 -C 4 alkyl, and wherein n is an integer from 1 to 12, and wherein i is an odd number and indicates the position relative to COOR 2 , and wherein X i independent of each other are selected from the group comprising O, S, SO, SO 2 , Se and CH 2 , and with the proviso that at least one of the X i is not CH 2 , and with the proviso that if R1 is an alkye, then the carbon-carbon triple bond is positioned between the (&ohgr;-1) carbon and the (&ohgr;-2) carbon, or between the (&ohgr;-2) carbon and the (&ohgr;-3) carbon, or between the (&ohgr;-3) carbon and the (&ohgr;-4) carbon, a salt, prodrug or complex thereof, which can be used for the treatment and/or prevention of syndrome X, obesity, hypertension, fatty liver, diabetes, hyperglycaemia, hyperinsulinemia and stenosis. Further, the invention relates to a nutritional composition comprising said fatty acid analogues, and a method for reducing the total weight, or the amount of adipose tissue in an animal.

  本发明涉及一种新型脂肪酸类似物，其一般式为(I)：R1—[xi—CH2]n—COOR2，其中R1是：具有一个或多个双键和/或一个或多个三键的C6-C24烯烃，和/或C6-C24炔烃，和/或在一个或多个位置上用来自氟化物、氯化物、羟基、C1-C4烷氧基、C1-C4烷基硫基、C2-C5酰氧基或C1-C4烷基的化合物组成的群体的一种或多种取代的C6-C24烷基；其中R2表示氢或C1-C4烷基，n为1到12的整数，i为奇数，表示相对于COOR2的位置，Xi独立于彼此，选自包括O、S、SO、SO2、Se和CH2的群体，但至少有一个Xi不是CH2，如果R1是炔烃，则碳-碳三键位于（ω-1）碳和（ω-2）碳之间，或者位于（ω-2）碳和（ω-3）碳之间，或者位于（ω-3）碳和（ω-4）碳之间，一种盐、前药或其复合物，可用于治疗和/或预防综合征X、肥胖、高血压、脂肪肝、糖尿病、高血糖、高胰岛素血症和狭窄。此外，本发明还涉及一种包含所述脂肪酸类似物的营养组合物，以及一种减少动物体内总体重或脂肪组织量的方法。
• Composition comprising plant and/or fish oils and non-oxidizable fatty acid entities
  申请人：Thia Medica AS

  公开号：EP2275140A2

  公开（公告）日：2011-01-19

  The present invention concerns a composition comprising a combination of a protein material, and a plant or fish oil, wherein the protein material is chosen from the group comprising single cell protein material (SCP), fish protein hydrolysate, or a fermented soy protein material, preferably Gendaxin®. The invention also relates to the use of such a composition for the preparation of a pharmaceutical or nutritional composition for the prevention and/or treatment of hypercholesterolemia and conditions negatively effected by high cholesterol levels, insulin resistance, obesity, diabetes, fatty liver, dyslipidemia, atherosclerosis, coronary heart disease, thrombosis, stenosis, secondary stenosis, myocardial infarction, stroke, elevated blood pressure, endothelial dysfunction, procoagulant state, polycystic ovary syndrome, the metabolic syndrome, cancer, inflammatory disorders and proliferate skin disorders.

  本发明涉及一种由蛋白质材料和植物油或鱼油组合而成的组合物，其中蛋白质材料选自单细胞蛋白质材料（SCP）、鱼蛋白水解物或发酵大豆蛋白材料，优选 Gendaxin®。本发明还涉及使用这种组合物制备药物或营养组合物，以预防和/或治疗高胆固醇血症和受高胆固醇水平、胰岛素抵抗、肥胖症、糖尿病、脂肪肝、血脂异常、动脉粥样硬化等负面影响的疾病、血脂异常、动脉粥样硬化、冠心病、血栓形成、血管狭窄、继发性血管狭窄、心肌梗塞、中风、血压升高、内皮功能障碍、促凝状态、多囊卵巢综合征、代谢综合征、癌症、炎症性疾病和增生性皮肤病。
• Natural lipids containing non-oxidizable fatty acids
  申请人：Bergen Teknologioverføring AS

  公开号：US10259833B2

  公开（公告）日：2019-04-16

  Provided herein is technology relating to natural lipids containing non-β-oxidizable fatty acids and particularly, but not exclusively, to compositions and methods related to the production and use of natural lipids containing non-β-oxidizable fatty acids.

  本文提供的技术涉及含有非β-可氧化脂肪酸的天然脂质，特别是（但不限于）与生产和使用含有非β-可氧化脂肪酸的天然脂质有关的组合物和方法。
• COMPOSITION COMPRISING PLANT AND/OR FISH OILS AND NON-OXIDIZABLE FATTY ACID ENTITIES
  申请人：Thia Medica AS

  公开号：EP1773397A2

  公开（公告）日：2007-04-18