1,2,2,3,3,4,4,7,7,8,8,9,9-Tridecafluoro-5,6,6-tris(trifluoromethyl)bicyclo[3.3.1]nonane

• 分子结构分类: 有机化合物 - 有机卤素化合物 - 有机氟化物
• 英文名称: 1,2,2,3,3,4,4,7,7,8,8,9,9-Tridecafluoro-5,6,6-tris(trifluoromethyl)bicyclo[3.3.1]nonane
• 化学式: C₁₂F₂₂
• 分子量: 562.09
• InChiKey: MNNBDIDBNFUDNH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  7.6
• 重原子数：
  34
• 可旋转键数：
  0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  22

文献信息

• Drug delivery compositions and methods
  申请人：QUIXOTE CORPORATION

  公开号：EP0274431A2

  公开（公告）日：1988-07-13

  Drug delivery compositions yield new and unexpected degrees of stabilization, solubilization and delivery of incorporated medicaments, drugs, or other physiologically-active compounds. The composi­tions enable administration of drugs and other medic­ally useful compounds via a variety of routes. More particularly, a drug delivery system or composition including one or more monomeric or polymerized sur­face active agents allows for rapid dissolution and smooth liberation of any desired incorporated drug or combinations, and the method of preparing the drug composition. In one embodiment, the physiologically-­active compound is encapsulated by a coacervate-derived film, and the finished product is suitable for trans­mucosal administration. Other formulations of this invention may be administered via inhalation, oral, parenteral and by transdermal routes.

  给药组合物能以意想不到的全新程度稳定、溶解和输送所含药物、毒品或其他具有生理活性的化合物。这些组合物可以通过多种途径给药和其他有医疗用途的化合物。更特别的是，包括一种或多种单体或聚合表面活性剂的给药系统或组合物可以快速溶解和顺利释放任何所需的掺入药物或组合物，以及制备药物组合物的方法。在一个实施方案中，生理活性化合物被一种由凝聚剂衍生的薄膜包裹，成品适合经粘膜给药。本发明的其他制剂可通过吸入、口服、肠外和透皮途径给药。
• SELF-HEALING CROSS-LINKABLE SHELLS
  申请人：ECOLE POLYTECHNIQUE FEDERALE DE LAUSANNE (EPFL)

  公开号：EP3563871A1

  公开（公告）日：2019-11-06

  The present invention relates to self-healing shells comprising a self-healing shell incorporating amphiphilic molecules having metal-coordinating group(s) reversibly cross-linked with metal cations.

  本发明涉及自愈合外壳，该外壳包含一种自愈合外壳，其中包含有与金属阳离子可逆交联的金属配位基团的两性分子。
• COMPOSITION OF GEL/GEL TYPE BASED ON HYDROPHOBIC COATED PIGMENTS AND A GLYCOL COMPOUND
  申请人：L'OREAL

  公开号：EP3578160A1

  公开（公告）日：2019-12-11

  The present invention relates to a composition of gel-gel type for making up and/or caring for keratin materials, containing: - at least one aqueous phase gelled with at least one synthetic hydrophilic gelling; and - at least one oily phase gelled with at least one lipophilic gelling agent; said phases forming therein a macroscopically homogeneous mixture and said composition also comprising: - at least one hydrophobic-coated pigment; and - at least one glycol compound of formula (2) below:          CH3-- [CH2CH2]m--[COO]n - CH2-CH(OH)-CH2OH     (2) in which: - m is between 2 and 4 - n is equal to 0 or 1; said gelled oily phase comprising at least one polar oil.

  本发明涉及一种用于制作和/或护理角蛋白材料的凝胶-凝胶型组合物，该组合物包含 - 至少一种与至少一种合成亲水性胶凝剂胶凝的水相；以及 - 至少一种与至少一种亲脂性胶凝剂胶凝的油相；所述各相在其中形成宏观上均匀的混合物，所述组合物还包括 - 至少一种疏水涂层颜料；以及 - 至少一种下式（2）的乙二醇化合物： CH3--[CH2CH2]m--[COO]n - CH2-CH(OH)-CH2OH (2) 其中 - m 介于 2 和 4 之间 - n 等于 0 或 1； 所述胶状油相至少包括一种极性油。
• Water-in-oil emulsion containing baicalin, a xanthine base, a vitamin B3, and a polyvalent metal cation salt
  申请人：L'OREAL

  公开号：US11376205B2

  公开（公告）日：2022-07-05

  The invention provides, in the field of caring for and/or making up keratin materials, especially the skin, a composition in water-in-oil emulsion form, containing: a) a continuous oily phase, b) a discontinuous aqueous phase dispersed in the oily phase; c) at least baicalin and/or a derivative thereof and/or a plant extract containing the compound(s); d) at least one vitamin B3 and/or a derivative thereof; e) at least one xanthine base and/or a plant extract containing same; and f) at least one polyvalent cation salt.

  本发明在护理和/或妆点角质材料（尤其是皮肤）领域提供了一种油包水型乳液组合物，其中含有 a) 连续油相、 b) 分散在油相中的非连续水相； c) 至少一种黄芩苷和/或其衍生物和/或含有该化合物的植物提取物； d) 至少一种维生素 B3 和/或其衍生物； e) 至少一种黄嘌呤碱和/或含有黄嘌呤碱的植物提取物；以及 f) 至少一种多价阳离子盐。
• Contrast agents
  申请人：NYCOMED IMAGING AS

  公开号：US20010019710A1

  公开（公告）日：2001-09-06

  Oil-in-water emulsions in which the oil phase comprises condensed or dissolved oil-soluble gas/fluid or gas precursor are useful as ultrasound contrast agents. Such products contain insignificant amounts of free gas bubbles or microbubbles in their stored form and exhibit good stability, but may be designed to promote rapid microbubble generation immediately before or upon administration.

  水包油型乳剂的油相中含有冷凝或溶解的油溶性气体/流体或气体前体，可用作超声造影剂。这类产品在储存状态下含有极少量的游离气泡或微泡，具有良好的稳定性，但可在给药前或给药后立即促进微泡的快速生成。