ethyl 3,5-diacetyl-1-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate | 1437798-85-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: ethyl 3,5-diacetyl-1-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate
• 英文别名: ethyl 3,5-diacetyl-1-(4-chlorophenyl)-2,6-dimethyl-4H-pyridine-4-carboxylate
• CAS: 1437798-85-0
• 化学式: C₂₀H₂₂ClNO₄
• 分子量: 375.852
• InChiKey: JPOJSMCAPRJSAT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  乙醛酸乙酯 、 对氯苯胺 、 乙酰丙酮 在 montmorillonite K-10 作用下， 以83%的产率得到ethyl 3,5-diacetyl-1-(4-chlorophenyl)-2,6-dimethyl-1,4-dihydropyridine-4-carboxylate
  参考文献：
  名称：

  Multicomponent reactions leading to symmetric and asymmetric multi-substituted 1,4-dihydropyridines on montmorillonite

  摘要：

  Highly functionalized multi-substituted symmetric and asymmetric 1,4-dihydropyridines were concisely synthesized in moderate to good yields via one-pot multicomponent reactions (MCRs) of beta-dicarbonyl compounds, aldehydes and amines at room temperature on montmorillonite. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfied yields and the reuse of the montmorillonite. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tet.2013.04.006

文献信息

• Multicomponent reactions leading to symmetric and asymmetric multi-substituted 1,4-dihydropyridines on montmorillonite
  作者：Yu-peng Liu、Jin-ming Liu、Xin Wang、Tie-ming Cheng、Run-tao Li

  DOI：10.1016/j.tet.2013.04.006

  日期：2013.6

  Highly functionalized multi-substituted symmetric and asymmetric 1,4-dihydropyridines were concisely synthesized in moderate to good yields via one-pot multicomponent reactions (MCRs) of beta-dicarbonyl compounds, aldehydes and amines at room temperature on montmorillonite. The merits of this method include the environmentally friendly reaction conditions, simple operation, broad substrate, satisfied yields and the reuse of the montmorillonite. (C) 2013 Elsevier Ltd. All rights reserved.