4-[(2-aminoethyl)(methyl)amino]pyridine | 796038-28-3

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: 4-[(2-aminoethyl)(methyl)amino]pyridine
• 英文别名: N-methyl-N-4-pyridinyl-1,2-ethanediamine；N¹-methyl-N¹-pyridin-4-yl-ethane-1,2-diamine；N1-Methyl-N1-pyridin-4-yl-ethane-1,2-diamine；N'-methyl-N'-pyridin-4-ylethane-1,2-diamine
• CAS: 796038-28-3
• 化学式: C₈H₁₃N₃
• 分子量: 151.211
• InChiKey: LUCZJSWUOIAORJ-UHFFFAOYSA-N

物化性质

• 沸点：
  271.8±20.0 °C(Predicted)
• 密度：
  1.073±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  42.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-[(2-aminoethyl)(methyl)amino]pyridine 在 sodium tetrahydroborate 作用下， 以 甲醇 为溶剂， 反应 6.5h， 生成 N-(3,5-bis{[2-(methyl[pyridin-4-yl]amino)ethylamino]methyl}benzyl)-N'-methyl-N'-pyridin-4-ylethane-1,2-diamine
  参考文献：
  名称：

  Effects of Polymer Architecture and Nanoenvironment in Acylation Reactions Employing Dendritic (Dialkylamino)pyridine Catalysts

  摘要：

  The role of architecture and nanoenvironment in the catalytic properties of dendritic polymers containing 4-(dialkylamino)pyridines was investigated in the context of acylation reactions employing sterically demanding tertiary alcohols as substrates. Frechet-type benzyl ether and aliphatic ester dendrimers were prepared in a convergent manner from a common trivalent core containing three DMAP groups while a linear polymer was dendronized with aliphatic esters using a divergent growth scheme. Catalysis experiments clearly indicate that nanoenvironment plays the dominant role in determining the activity of the polymer catalysts, with the polyester platform being superior to the benzyl ether. Polymer architecture played little or no role in affecting catalysis. With respect to molecular transport and catalysis, this represents the first comparative study of the effect of architecture and nanoenvironment using structurally similar dendritic materials.

  DOI：

  10.1021/ma050701m
• 作为产物：
  描述：

  2-(吡啶-4-甲基氨基)乙醇 在 偶氮二甲酸二异丙酯 、 一水合肼 、 三苯基膦 作用下， 以 四氢呋喃 、 乙醇 为溶剂， 反应 3.0h， 生成 4-[(2-aminoethyl)(methyl)amino]pyridine
  参考文献：
  名称：

  多金属氧酸盐基有机催化剂中的分子内阴离子效应：金属氧化物与有机阳离子相互作用的反应性增强和手性转移

  摘要：

  的α 1 -Dawson聚阴离子轴承用4-氨基吡啶端基的横向侧链的合成。这种有机多金属氧酸盐催化将茚基烯丙基硅烷加到肉桂酰氟上。聚阴离子骨架影响有机催化剂的活性和选择性。观察到从手性无机骨架到有机底物的适度但非零的手性转移。

  DOI：

  10.1002/chem.201403989

文献信息

• Shell Cross‐Linked Micelles as Nanoreactors for Enantioselective Three‐Step Tandem Catalysis
  作者：Michael Kuepfert、Aaron E. Cohen、Olivia Cullen、Marcus Weck

  DOI：10.1002/chem.201804956

  日期：2018.12.12

  enantio‐enriched alcohols in the cross‐linked shell, and nucleophilic base‐catalyzed acylation in the hydrophobic core. The catalysts are positioned in close proximity on a single micelle support to take advantage of the intramicellar substrate diffusion, yet they are sufficiently spaced apart from each other in physically distinct microenvironments. These compartmentalized micelles are substrate selective

  描述了组装成壳交联胶束（SCM）的功能化两亲性聚（2-恶唑啉）基三嵌段共聚物。这些胶束可通过分隔将三种不相容的催化剂进行位点分离，从而在一锅中实现三步非正交串联工艺。尤其是，在亲水性电晕中酸催化的缩酮水解为前手性酮，然后在交联壳中进行Rh催化的不对称转移氢化为对映体富集的醇，并在疏水核中进行了亲核碱催化的酰化反应。将催化剂紧密地放置在单个胶束载体上，以利用胶束内底物扩散的优势，但它们在物理上不同的微环境中彼此充分隔开。
• [EN] 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE - 3 - CARBOXYLIC ACID AMIDE DERIVATIVES AND RELATED COMPOUNDS AS BRADYKININ B1 RECEPTOR ANTAGONISTS FOR THE TREATMENT OF INFLAMMATORY DISEASES<br/>[FR] DERIVES AMIDES DE L'ACIDE CARBOXYLIQUE DE 4- BROMO - 5 - (2- CHLORO - BENZOYLAMINO) - 1H - PYRAZOLE 3 ET COMPOSES ASSOCIES EN TANT QU'ANTAGONISTES DE RECEPTEUR DE B1 DE LA BRADYKININE POUR LE TRAITEMENT DE MALADIES INFLAMMATOIRES
  申请人：ELAN PHARM INC

  公开号：WO2004098589A1

  公开（公告）日：2004-11-18

  Disclosed are compounds of formula I and II that are bradykinin B1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  公开的是化合物I和II的结构式，它们是激肽酶B1受体拮抗剂，适用于治疗哺乳动物中由激肽酶B1受体介导的疾病，或缓解与疾病状况相关的不良症状。其中某些化合物表现出增强的效力，并且预计还将表现出延长作用的特性。
• Bis (amino acid) molecular scaffolds
  申请人：——

  公开号：US20040077879A1

  公开（公告）日：2004-04-22

  The present invention provides molecular building blocks of rigid bis(amino acids). The molecular building blocks can be linked together through the formation of rigid diketopiperazine rings, to provide the desired three dimensional structure. Also provided is method of synthesizing macromolecules from the bis (amino acid) building blocks.

  本发明提供了刚性双(氨基酸)的分子构建模块。这些分子构建模块可以通过形成刚性二酮二肽环相互连接，以提供所需的三维结构。同时提供了一种从双(氨基酸)构建模块合成高分子的方法。
• Substituted pyrazole derivatives and related compounds as bradykinin B1 receptor antagonists
  申请人：Tung S. Jay

  公开号：US20050020659A1

  公开（公告）日：2005-01-27

  Disclosed are compounds that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  本发明公开了一种布雷肯肽B1受体拮抗剂化合物，可用于治疗哺乳动物中由布雷肯肽B1受体介导的疾病或缓解与疾病状况相关的不良症状。其中某些化合物表现出增强的效力，并且预计也会表现出增强的作用持续时间。
• 4-Bromo-5-(2-chloro-benzoylamino)-1h-pyrazole-3-carvoxylic acid amide derivatives and related compounds as bradykinin b1 receptor antagonists for the treatment of inflammatory diseases
  申请人：Tung S. Jay

  公开号：US20060281733A1

  公开（公告）日：2006-12-14

  Disclosed are compounds of formula I and II that are bradykinin B 1 receptor antagonists and are useful for treating diseases, or relieving adverse symptoms associated with disease conditions, in mammals mediated by bradykinin B 1 receptor. Certain of the compounds exhibit increased potency and are also expected to exhibit increased duration of action.

  本发明公开了式I和式II的化合物，它们是缓激肽B1受体拮抗剂，可用于治疗哺乳动物中由缓激肽B1受体介导的疾病，或缓解与疾病条件相关的不良症状。其中某些化合物表现出增强的效力，预计也会表现出增强的持续时间。