2-(全氟丁基)四氢呋喃 | 26446-59-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四氢呋喃
• 中文名称: 2-(全氟丁基)四氢呋喃
• 中文别名: 2-九氟丁基四氢呋喃
• 英文名称: Perfluorobutyltetrahydrofuran
• 英文别名: 2-(1,1,2,2,3,3,4,4,4-nonafluorobutyl)oxolane
• CAS: 26446-59-3
• 化学式: C₈H₇F₉O
• 分子量: 290.13
• InChiKey: CJFUEPJVIFJOOU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• [EN] PROCESS FOR PRODUCTION OF 2,3,3,3-TETRAFLUOROPROPENE<br/>[FR] PROCÉDÉ DE PRODUCTION DU 2,3,3,3-TÉTRAFLUOROPROPÈNE
  申请人：DAIKIN IND LTD

  公开号：WO2010013795A1

  公开（公告）日：2010-02-04

  The present invention provides a process for producing 2,3,3,3-tetrafluoropropene including the following reaction steps: (i) reducing a halogenated fluoropropane represented by formula (1): ACF2CF2CH2FyAz, wherein A is Cl, Br, or I; x is an integer from 0 to 2; y and z are each an integer from 0 to 3; and the total number of x, y, and z is 3, to produce a 1-halogenated-1,1,2,2-tetrafluoropropane represented by formula (2): ACF2CF2CH3; and (ii) contacting the 1-halogenated-1,1,2,2-tetrafluoropropane obtained in step (i) with a catalyst in a gas phase to produce 2,3,3,3-tetrafluoropropene. According to the invention, 2,3,3,3-tetrafluoropropene (HFO-1234yf) can be produced in a high yield, using inexpensive starting materials.

  本发明提供了一种生产2,3,3,3-四氟丙烯的方法，包括以下反应步骤：(i) 还原由式(1)表示的卤代氟丙烷：ACF2CF2CH2FyAz，其中A为Cl、Br或I；x为0到2的整数；y和z分别为0到3的整数；以及x、y和z的总数为3，以产生由式(2)表示的1-卤代-1,1,2,2-四氟丙烷：ACF2CF2CH3；以及(ii) 将步骤(i)中获得的1-卤代-1,1,2,2-四氟丙烷与气相中的催化剂接触，以产生2,3,3,3-四氟丙烯。根据本发明，可以使用廉价的起始材料高产率地生产2,3,3,3-四氟丙烯（HFO-1234yf）。
• MEDICINAL PREPARATION
  申请人：TORAY INDUSTRIES, INC.

  公开号：EP1787661A1

  公开（公告）日：2007-05-23

  A pharmaceutical preparation has a ligand structure specifically recognizing a target site and an amphiphilic compound having a hydrophobic or amphiphilic group. The pharmaceutical preparation employs an amphiphilic compound of specific structure obtained by introducing a chained hydrophilic group with an appropriate flexibility, and thus becomes a fine particle suited for drug targeting. The pharmaceutical preparation is expected to give a prolonged pharmacological effect. A particulate preparation exhibiting a remarkable site targeting property can be formed. Further, according to the selection of matrix forming material, the drug releasing property can be controlled.

  一种药物制剂具有特异性识别靶位点的配体结构和具有疏水或两性亲和性基团的两性化合物。该药物制剂采用通过引入具有适当柔韧性的链状亲水基团获得的特定结构的两性化合物，因此成为适用于药物靶向的细颗粒。 预计该药物制剂将产生持久的药理效应。可以形成具有显著靶向性能的颗粒制剂。此外，根据基质形成材料的选择，可以控制药物释放性能。
• HYDROFLUOROETHER OLEFINS AND METHODS OF USING SAME
  申请人：3M INNOVATIVE PROPERTIES COMPANY

  公开号：US20170198186A1

  公开（公告）日：2017-07-13

  A hydrofluoroether compound represented by the following general formula (I).

  由以下一般式（I）表示的氢氟醚化合物。
• NANOEMULSIONS AND USE THEREOF AS CONTRAST AGENTS
  申请人：GUERBET

  公开号：US20140234223A1

  公开（公告）日：2014-08-21

  The invention relates to an oil-in-water nanoemulsion for MRI, including: an aqueous phase, a fluorinated phase including at least one fluorinated oil, a surfactant at the interface between the aqueous and fluorinated phases, the surfactant comprising: at least one amphiphilic targeting ligand, at least one amphiphilic lipid, and at least one diblock or triblock fluorophilic compound, as well as to the use thereof as a contrast agent.

  这项发明涉及一种用于磁共振成像的油包水纳米乳液，包括： 水相， 含有至少一种氟化油的氟化相， 位于水相和氟化相之间的表面活性剂，所述表面活性剂包括： 至少一种两性靶向配体， 至少一种两性脂质，以及 至少一种二嵌段或三嵌段亲氟化合物， 以及将其用作对比剂的用途。
• [EN] HYDROFLUORETHERS AND METHODS OF USING SAME<br/>[FR] HYDROFLUORÉTHERS ET LEURS PROCÉDÉS D'UTILISATION
  申请人：3M INNOVATIVE PROPERTIES CO

  公开号：WO2021144678A1

  公开（公告）日：2021-07-22

  A compound having structural formula (II): where R2 is H, CH3, CF3, CH2CF2CF2H, or CH2CF2CF2CF2CF2H; where R2f is a perfluoroalkyl group having 1-4 carbon atoms, optionally comprising either or both of a catenated nitrogen heteroatom and a catenated oxygen heteroatom; where R2f' is CF3 or CF2CF3; and where R2f" is CF3 or CF2CF3; with the proviso that when R2f' is CF3, then R2f" is CF3, and when R2 is H or CH3, then R2f is not CF3.

  具有结构式（II）的化合物：其中R2为H、CH3、CF3、CH2CF2CF2H或 CF2CF2CF2CF2H；其中R2f为具有1-4个碳原子的全氟烷基基团，可选地包括串联的氮杂原子和/或串联的氧杂原子中的任一种或两种；其中R2f'为 或CF2 ；其中R2f"为 或CF2 ；但是当R2f'为 时，R2f"为 ，当R2为H或 时，R2f不是 。