Acetonedicarboxylic acid dianilide | 40315-17-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Acetonedicarboxylic acid dianilide
• 英文别名: 3-oxo-glutaric acid dianilide；3-oxo-pentanedioic acid dianilide；3-Oxo-glutarsaeure-dianilid；3-Hydroxy-pentendisaeure-dianilid；Aceton-α.α'-dicarbonsaeure-dianilid；1.3-Di-(phenylcarbamoyl)-aceton；3-oxo-N,N'-diphenyl-pentanediamide；3-oxo-N,N'-diphenylpentanediamide
• CAS: 40315-17-1
• 化学式: C₁₇H₁₆N₂O₃
• 分子量: 296.326
• InChiKey: AESIZHIFMSVOSV-UHFFFAOYSA-N

物化性质

• 熔点：
  154-155 °C
• 沸点：
  605.6±40.0 °C(Predicted)
• 密度：
  1.287±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  22
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Acetonedicarboxylic acid dianilide 在 吡啶 、 sodium hydroxide 、 sodium acetate 作用下， 以 溶剂黄146 为溶剂， 反应 2.0h， 生成 2-{5-Cyano-6-imino-3-[(4-methoxy-phenyl)-hydrazono]-2-oxo-1-phenyl-1,2,3,6-tetrahydro-pyridin-4-yl}-N-phenyl-acetamide
  参考文献：
  名称：

  El-Reedy, A. M.; Ibrahim, M. K. A.; Hussain, S. M., Journal fur praktische Chemie (Leipzig 1954), 1989, vol. 331, # 5, p. 745 - 750

  摘要：

  DOI：
• 作为产物：
  描述：

  苯胺 、 alkaline earth salt of/the/ methylsulfuric acid 生成 Acetonedicarboxylic acid dianilide
  参考文献：
  名称：

  Kaushal, Journal of the Indian Chemical Society, 1943, vol. 20, p. 127,129

  摘要：

  DOI：

文献信息

• Antimicrobial Activities of some Synthesized Pyridines, Oxazines and Thiazoles from 3-Aryl-1-(2-naphthyl)prop-2-en-1-ones
  作者：Salwa Mohamed

  DOI：10.3797/scipharm.0804-09

  日期：——

  3-Aryl-1-(2-naphthyl)-prop-2-en-1-ones were reacted with ethyl cyanoacetate to produce 4-aryl-6-(2-naphthyl)-2-oxo-1,2-dihydropyridine-3-carbonitriles, which were treated with ethyl chloroacetate to give the corresponding ester. Treatment of the latter ester with hydrazine hydrate or anthranilic acid afforded hydrazides and benzoxazines. The hydrazides were reacted with benzaldehyde or phenylisothiocyanate to afford the corresponding hydrazone and thiosemicarbazide derivatives, which were cyclized with chloroacetic acid or thioglycolic acid to the corresponding thiazole derivatives. 3-Aryl-1-(2-naphthyl)-prop-2-en-1-ones were either condensed with malononitrile under different conditions to produce carbonitrile derivatives or treated with active methylene reagents to afford the substituted cyclohexene derivatives. The structure assignment of the new compounds is based on chemical and spectroscopic evidence. Some of these compounds exhibited antimicrobial activities comparable to Ampicillin® as reference drug.

  3-芳基-1-(2-萘基)-丙-2-烯-1-酮与乙基氰乙酸酯反应，生成4-芳基-6-(2-萘基)-2-氧-1,2-二氢吡啶-3-氰基，随后与乙基氯乙酸酯处理以得到相应的酯。将后续酯与水合肼或邻氨基苯甲酸处理，得到肼和苯并噁唑衍生物。这些肼与苯甲醛或苯异硫氰酸酯反应，得到相应的肼亚胺和噻唑半卡巴肟衍生物，然后与氯乙酸或硫醇酸环化，生成相应的噻唑衍生物。3-芳基-1-(2-萘基)-丙-2-烯-1-酮在不同条件下与马隆腈缩合生成氰基衍生物，或与活性亚甲基试剂反应生成取代的环己烯衍生物。新化合物的结构指派基于化学和光谱证据。这些化合物中的一些显示出与阿莫西林®相当的抗微生物活性。
• Hammouda, Hamdy A.; El-Reedy, Ahmed M.; Hussain, Sohair M., Journal of Heterocyclic Chemistry, 1986, vol. 23, p. 1203 - 1206
  作者：Hammouda, Hamdy A.、El-Reedy, Ahmed M.、Hussain, Sohair M.

  DOI：——

  日期：——
• Zayed, M. A.; Abou-Taleb, Salah A.; El-Morsy, M. M. S., Journal of the Indian Chemical Society, 1982, vol. 59, # 8, p. 1013 - 1015
  作者：Zayed, M. A.、Abou-Taleb, Salah A.、El-Morsy, M. M. S.

  DOI：——

  日期：——
• Synthesis of salts of new arylamides of 2-hydroxy-5-nitroso-4,6-dimethylisophthalic acid
  作者：N. A. Fedorova、D. G. Slaschinin、A. B. Lyubyashkin、I. V. Peterson、M. S. Tovbis

  DOI：10.1134/s1070428013080241

  日期：2013.8
• Ali,M.I.; El-Morsy,M.M.S., Journal fur praktische Chemie (Leipzig 1954), 1979, vol. 321, p. 1047 - 1052
  作者：Ali,M.I.、El-Morsy,M.M.S.

  DOI：——

  日期：——