acetaldehyde-(Z)-phenylhydrazone | 27935-60-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: acetaldehyde-(Z)-phenylhydrazone
• 英文别名: Acetaldehyd-(Z)-phenylhydrazon；Acetaldehyd-(phenyl-seqcis-hydrazon)；acetaldehyde phenylhydrazone；β-Acetaldehyd phenylhydrazon；β-Acetaldehydphenylhydrazon；anti-Acetaldehyd-phenylhydrazon；Acetaldehyde phenylhy-drazone；N-[(Z)-ethylideneamino]aniline
• CAS: 27935-60-0
• 化学式: C₈H₁₀N₂
• 分子量: 134.181
• InChiKey: KURBTRNHGDQKOS-MBXJOHMKSA-N

物化性质

• 沸点：
  229.2±13.0 °C(Predicted)
• 密度：
  0.95±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  10
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  24.4
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  acetaldehyde-(Z)-phenylhydrazone 生成 acetaldehyde phenylhydrazone
  参考文献：
  名称：

  Pyrolysis of Pyruvic Acid Hydrazones¹

  摘要：

  DOI：

  10.1021/ja01545a029

文献信息

• Pyrazolones as inhibitors of 11B-hydroxysteroid dehydrogenase
  申请人：Banner Lester Bruce

  公开号：US20070049632A1

  公开（公告）日：2007-03-01

  Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as, for example, type II diabetes mellitus and metabolic syndrome.

  本文提供了以下式(I)的化合物： 以及其药学上可接受的盐，其中取代基如规范中所披露的那样。这些化合物及含有它们的药物组合物对于治疗诸如II型糖尿病和代谢综合征等疾病是有用的。
• ANTIFUNGAL COMPOUNDS AND METHODS OF FORMING THE SAME
  申请人：University of Kentucky Research Foundation

  公开号：US20200024224A1

  公开（公告）日：2020-01-23

  An antifungal composition and a method of treating a systemic fungal infection are provided herein. The antifungal composition includes a diaryl bishydrazone. The method includes administering a therapeutically effective amount of the diaryl bishydrazone to a subject in need thereof.

  本文提供了一种抗真菌组合物和治疗系统真菌感染的方法。该抗真菌组合物包括二芳基双脲酮。该方法包括向需要的受试者施用治疗有效量的二芳基双脲酮。
• Curable composition
  申请人：SUMITOMO CHEMICAL COMPANY, LIMITED

  公开号：EP0039230A2

  公开（公告）日：1981-11-04

  Acurable resin composition comprising an epoxy resin, a hardener and an epoxy compound-dialkyl-amine adduct as a latent hardener. The composition has good storage stability at ambient temperatures and is rapidly heat-curable, and is usable as or in adhesives, paints, molding materials, and casting materials.

  由环氧树脂、固化剂和作为潜在固化剂的环氧化合物-二烷基-胺加合物组成的可固化树脂组合物。该组合物在环境温度下具有良好的储存稳定性，并能快速热固化，可用作粘合剂、涂料、成型材料和铸造材料。
• Heat curable organopolysiloxane compositions
  申请人：Wacker Silicones Corporation

  公开号：EP0274114A2

  公开（公告）日：1988-07-13

  Heat curable organopolysiloxane compositions comprising an organopolysiloxane having Si-bonded aliphatically unsaturated groups, an organohydrogenpolysiloxane having Si-­bonded hydrogen atoms, a platinum catalyst capable of promoting the addition of Si-bonded hydrogen to Si-bonded aliphatically unsaturated groups and a hydrazone compound. The resultant composition is stable at room temperature, but when heated to an elevated temperature cures to an elastomer.

  可加热固化的有机聚硅氧烷组合物，包括具有硅键脂肪族不饱和基团的有机聚硅氧烷、具有硅键氢原子的有机氢聚硅氧烷、能够促进硅键氢与硅键脂肪族不饱和基团加成的铂催化剂以及腙化合物。所得组合物在室温下稳定，但加热到高温时会固化成弹性体。
• CYANOPYRROLIDINES AS DUB MODULATORS
  申请人：Mission Therapeutics Limited

  公开号：EP3828179A1

  公开（公告）日：2021-06-02

  The present invention relates to novel compounds and methods for the manufacture of inhibitors of deubiquitylating enzymes (DUBs). In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase LI (UCHL1). The invention further relates to the use of DUB inhibitors in the treatment of cancer and other indications. Compounds of the invention include compounds having the formula (I) or a pharmaceutically acceptable salt thereof, wherein R1 to R8 are as defined herein.

  本发明涉及新型化合物和制造去泛素化酶（DUB）抑制剂的方法。特别是，本发明涉及泛素 C 端水解酶 LI（UCHL1）的抑制。本发明进一步涉及 DUB 抑制剂在治疗癌症和其他适应症中的用途。本发明的化合物包括具有式 (I) 的化合物 或其药学上可接受的盐，其中 R1 至 R8 如本文所定义。