3,5,2'-trimethoxybiphenyl | 95742-31-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3,5,2'-trimethoxybiphenyl
• 英文别名: 1,3-Dimethoxy-5-(2-methoxyphenyl)benzene；1,3-dimethoxy-5-(2-methoxyphenyl)benzene
• CAS: 95742-31-7
• 化学式: C₁₅H₁₆O₃
• 分子量: 244.29
• InChiKey: HGFAQNLRDYJPOY-UHFFFAOYSA-N

物化性质

• 沸点：
  336.1±27.0 °C(Predicted)
• 密度：
  1.077±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  18
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3,5,2'-trimethoxybiphenyl 生成 2'-methoxyaucuparin
  参考文献：
  名称：

  Nilsson,M.; Norin,T., Acta Chemica Scandinavica (1947), 1963, vol. 17, # 4, p. 1157 - 1159

  摘要：

  DOI：
• 作为产物：
  描述：

  5-(2-甲氧基苯)环己烷1,3-二酮 在 palladium on activated charcoal 作用下， 以 二苯醚 为溶剂， 生成 3,5,2'-trimethoxybiphenyl
  参考文献：
  名称：

  Nilsson,M.; Norin,T., Acta Chemica Scandinavica (1947), 1963, vol. 17, # 4, p. 1157 - 1159

  摘要：

  DOI：

文献信息

• Tetra-<i>ortho</i>-Substituted Biaryls through Palladium-Catalyzed Suzuki−Miyaura Couplings with a Diaminochlorophosphine Ligand
  作者：Lutz Ackermann、Harish K. Potukuchi、Andreas Althammer、Robert Born、Peter Mayer

  DOI：10.1021/ol1000186

  日期：2010.3.5

  A palladium complex derived from a sterically hindered diaminochlorophosphine allowed for Suzuki−Miyaura cross-couplings of chloroarenes with ample scope and provided access to tetra-ortho-substituted bi(hetero)aryls.

  衍生自空间受阻的二氨基氯膦的钯配合物可以使氯芳烃的Suzuki-Miyaura交叉偶联具有足够的范围，并提供四邻位取代的双（杂）芳基的通道。
• Resorcinarene-mono-benzimidazolium salts as NHC ligands for Suzuki--Miyaura cross-couplings catalysts
  作者：Ümit İŞCİ、Muhittin AYGÜN、Resul SEVİNCEK、Yunus ZORLU、Fabienne DUMOULİN

  DOI：10.3906/kim-1506-50

  日期：——

  Two mono-benzimidazolium salts of resorcinarene have been prepared and used as ligands in Suzuki--Miyaura cross-coupling reactions. They have been fully characterized by $^1}$H and $^13}$C NMR, MALDI, and FT-IR spectroscopic methods, and their structures were confirmed by X-ray diffraction analysis. These two new resorcinarene-based mono-benzimidazolium salts showed good catalytic activity for coupling reactions in DMF. The highest conversion was achieved for arylation of 4-bromotoluene using the resorcinarenyl mono-dimethylbenzimidazolium salt.

  已经制备了两种基于重氮树脂的单苯并咪唑盐，并作为配体用于铃木-宫浦交叉偶联反应。它们通过 $^1}$H 和 $^13}$C NMR、MALDI 和 FT-IR 光谱方法进行了全面表征，并通过 X 射线衍射分析确认了其结构。这两种新的基于重氮树脂的单苯并咪唑盐在 DMF 中对偶联反应表现出良好的催化活性。使用重氮树脂单二甲基苯并咪唑盐对 4-溴甲苯进行芳基化反应时，达到了最高转化率。
• Air-Stable PinP(O)H as Preligand for Palladium-Catalyzed Kumada Couplings of Unactivated Tosylates
  作者：Lutz Ackermann、Andreas Althammer

  DOI：10.1021/ol061116o

  日期：2006.8.1

  Air-stable and easily accessible PinP(O)H enables highly efficient palladium-catalyzed Kumada cross-coupling reactions of aryl tosylates. The in situ generated catalyst proved applicable not only to electron-rich and electron-poor carbocyclic tosylates but also to heterocyclic tosylates, such as pyridine and quinoline derivatives. The results described herein constitute the first use of air-stable secondary phosphine oxides as preligands for transition-metal-catalyzed coupling reactions between organometallic species and tosylates.
• Formation and exudation of biphenyl and dibenzofuran phytoalexins by roots of the apple rootstock M26 grown in apple replant disease soil
  作者：Belnaser A. Busnena、Till Beuerle、Felix Mahnkopp-Dirks、Traud Winkelmann、Ludger Beerhues、Benye Liu

  DOI：10.1016/j.phytochem.2021.112972

  日期：2021.12