diethyl 2-diphenylphosphinoylbutanedioate | 33493-50-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: diethyl 2-diphenylphosphinoylbutanedioate
• 英文别名: diethyl (2-diphenylphosphinoyl)succinate；diethyl 2-(diphenylphosphoryl)succinate；(Diphenylphosphinyl)bernsteinsaeurediaethylester；Diethyl 2-(diphenylphosphoryl)butanedioate；diethyl 2-diphenylphosphorylbutanedioate
• CAS: 33493-50-4
• 化学式: C₂₀H₂₃O₅P
• 分子量: 374.373
• InChiKey: BROCUFYDJLHLJZ-UHFFFAOYSA-N

物化性质

• 沸点：
  479.3±35.0 °C(Predicted)
• 密度：
  1.19±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  26
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.3
• 拓扑面积：
  69.7
• 氢给体数：
  0
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  diethyl 2-diphenylphosphinoylbutanedioate 在 一水合肼 作用下， 以 乙醇 为溶剂， 生成 2-diphenylphosphorylbutanedihydrazide
  参考文献：
  名称：

  Razumov,A.I. et al., Journal of general chemistry of the USSR, 1971, vol. 41, p. 1248 - 1249

  摘要：

  DOI：
• 作为产物：
  描述：

  Diphenylphosphine oxide 、 but-2-enedioic acid diethyl ester 在 四乙基对甲苯磺酸铵 作用下， 以 二氯甲烷 为溶剂， 反应 3.0h， 以96%的产率得到diethyl 2-diphenylphosphinoylbutanedioate
  参考文献：
  名称：

  Hydrophosphorylation of electron-deficient alkenes and alkynes mediated by convergent paired electrolysis

  摘要：

  一种直接实用的策略被描述用于通过CPE策略，在无需金属、碱和氧化还原试剂的情况下，对电子不足的烯烃和炔烃进行水膜磷化反应，以获得γ-酮基膦氧化物。

  DOI：

  10.1039/d2cc02745c

文献信息

• Potassium Carbonate Promoted Nucleophilic Addition of Alkenes with Phosphites
  作者：Shengmei Guo、Zhenjun Huang、Wei Liu、Sen Li、Yutian Yang、Hu Cai

  DOI：10.1055/s-0040-1707852

  日期：2020.8

  A facile hydrophosphonylation of alkenes by phosphites promoted by potassium carbonate was developed. The reaction features include easy handling, environmental friendliness, and avoidance of the use of strong bases. A variety of alkenes are tolerated in this reaction, with moderate to excellent yields.

  开发了一种由碳酸钾促进的亚磷酸酯对烯烃的轻松氢膦酰化。反应特点包括易于处理、环境友好和避免使用强碱。该反应可以耐受多种烯烃，产率中等至极好。
• Bimetallic ruthenium–rhodium particles supported on carbon nanotubes for the hydrophosphinylation of alkenes and alkynes
  作者：Dhanaji V. Jawale、Frédéric Fossard、Frédéric Miserque、Valérie Geertsen、Eric Doris、Edmond Gravel

  DOI：10.1039/d2cy00857b

  日期：——

  Bimetallic ruthenium–rhodium nanoparticles were assembled on carbon nanotubes and applied to the hydrophosphinylation reaction of olefin and alkyne-containing compounds. The system proved efficient under mild and sustainable conditions, operating with low catalyst loading, at room temperature, and under atmospheric pressure. In addition, the catalytic hybrid could be recycled and reused over multiple

  将双金属钌-铑纳米粒子组装在碳纳米管上，并应用于烯烃和炔烃化合物的氢膦酰化反应。该系统在温和和可持续的条件下被证明是有效的，在低催化剂负载、室温和大气压下运行。此外，催化混合可以在多个循环中回收和重复使用。
• Silver-catalyzed radical bisphosphonation reaction of maleimides with diarylphosphine oxides
  作者：Wen Zhang、Hong-Li Ruan、Zhi-Jia Zhu、Sheng-Yin Zhao

  DOI：10.1016/j.tetlet.2023.154464

  日期：2023.5

  A silver-catalyzed bisphosphonate reaction of substituted maleimides with various diarylphosphine oxides was developed. This methodology provided an efficient strategy to prepare phosphorus–containing succinimide derivatives with satisfactory yields. The reaction exhibited mild reaction conditions and good functional group compatibilities. The radical species induced pathway was also demonstrated by

  开发了取代的马来酰亚胺与各种二芳基膦氧化物的银催化双膦酸盐反应。该方法为制备含磷琥珀酰亚胺衍生物提供了一种有效的策略，且收率令人满意。该反应表现出温和的反应条件和良好的官能团相容性。机理研究也证明了自由基物种诱导途径。
• Yarkevich, A. N.; Tsvetkov, E. N., Russian Journal of General Chemistry, 1994, vol. 64, # 10.1, p. 1451 - 1455
  作者：Yarkevich, A. N.、Tsvetkov, E. N.

  DOI：——

  日期：——
• Physiologically active bis(dialkylamides) of phosphoryl-substituted α,ω-dicarboxylic acids
  作者：A. N. Yarkevich、Z. V. Safronova、L. N. Petrova、A. V. Gabrelyan、V. L. Zamoyski、V. V. Grigor’ev、S. O. Bachurin、N. S. Zefirov

  DOI：10.1134/s1070363213010076

  日期：2013.1

  Bis(dialkylamides) of phosphoryl-substituted alpha,omega-dicarboxylic acids were synthesized and their biological activity was studied.