pyrrolidinyl-2,2-diethylbutyramide | 78986-73-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯烷类
• 英文名称: pyrrolidinyl-2,2-diethylbutyramide
• 英文别名: 2,2-Diethyl-1-pyrrolidin-1-ylbutan-1-one
• CAS: 78986-73-9
• 化学式: C₁₂H₂₃NO
• 分子量: 197.321
• InChiKey: NCPYXJKVIAJDEC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  pyrrolidinyl-2,2-diethylbutyramide 在 氘代甲醇-d 、 四甲基乙二胺 、 仲丁基锂 作用下， 生成 2,2-diethyl-1-(pyrrolidin-1-yl-2-d)butan-1-one
  参考文献：
  名称：

  Dipole-stabilized carbanions: secondary (.alpha.-lithioalkyl)alkylamine synthetic equivalents from N,N-dialkyl-2,2-diethylbutyramides

  摘要：

  DOI：

  10.1021/jo00334a052
• 作为产物：
  描述：

  2,2-diethylbutanoyl chloride 、 四氢吡咯 以86%的产率得到
  参考文献：
  名称：

  REITZ, D. B.;BEAK, P.;TSE, A., J. ORG. CHEM., 1981, 46, N 21, 4316-4317

  摘要：

  DOI：

文献信息

• ISOXAZOLE DERIVATIVE AND ISOTHIAZOLE DERIVATIVE HAVING INHIBITORY ACTIVITY ON 11(beta)-HYDROXYSTEROID DEHYDROGENASE TYPE I
  申请人：Ogawa Tomoyuki

  公开号：US20090131491A1

  公开（公告）日：2009-05-21

  Disclosed is a compound useful as an inhibitor of 11β-hydroxysteroid dehydrogenase type 1. A compound represented by the formula: a pharmaceutically acceptable salt or solvate thereof, wherein R 1 is a group of the formula: —C(═O)NR 4 R 5 , (wherein R 4 and R 5 are each independently, hydrogen, optionally substituted alkyl or the like) or a group of the formula: —NR 6 C(═O)R 7 , (wherein R 6 and R 7 are each independently, hydrogen, optionally substituted alkyl or the like), X and Y are each independently —O— or the like, Z is a bond or the like, R 2 is optionally substituted alkyl, optionally substituted alkenyl or the like, R 3 is optionally substituted alkyl, optionally substituted alkenyl or the like.
• US8017638B2
  申请人：——

  公开号：US8017638B2

  公开（公告）日：2011-09-13
• Dipole-stabilized carbanions: secondary (.alpha.-lithioalkyl)alkylamine synthetic equivalents from N,N-dialkyl-2,2-diethylbutyramides
  作者：David B. Reitz、Peter Beak、Anthony Tse

  DOI：10.1021/jo00334a052

  日期：1981.10
• REITZ, D. B.;BEAK, P.;TSE, A., J. ORG. CHEM., 1981, 46, N 21, 4316-4317
  作者：REITZ, D. B.、BEAK, P.、TSE, A.

  DOI：——

  日期：——