3-chloro-2,4,6-trimethylpyridine | 90006-47-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 3-chloro-2,4,6-trimethylpyridine
• 英文别名: 3-Chlor-2,4,6-trimethyl-pyridin；Collidine chloride
• CAS: 90006-47-6
• 化学式: C₈H₁₀ClN
• 分子量: 155.627
• InChiKey: XMDADURFCJZPPJ-UHFFFAOYSA-N

物化性质

• 沸点：
  201.2±35.0 °C(Predicted)
• 密度：
  1.084±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  10
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  12.9
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  2,4,6-三甲基吡啶 在 三氯异氰尿酸 、 二乙基[4-[[4-(二乙基氨基)苯基]苯基亚甲基]-2,5-环己二烯-1-亚基]铵 作用下， 以 乙腈 为溶剂， 反应 27.0h， 以72%的产率得到3-chloro-2,4,6-trimethylpyridine
  参考文献：
  名称：

  三氯异氰尿酸（TCCA）通过催化有机染料活化来扩增芳烃和杂芳烃的氯化反应性

  摘要：

  使用三氯异氰尿酸（TCCA）和催化艳绿（BG）以良好至极佳的收率（可缩放至克级）对含有吸电子基团的杂芳烃和芳烃进行氯化处理。BG的可见光活化可增强TCCA的亲电性质，为失活的（杂）芳族底物的酸促进氯化提供了温和的替代方法。通过与其他氯化试剂进行比较以及对包括咖啡因，利多卡因和非那酮在内的药物进行氯化，证明了TCCA / BG系统的实用性。

  DOI：

  10.1021/acs.orglett.9b01414

文献信息

• Compounds targeting proteins, compositions, methods, and uses thereof
  申请人：BioTheryX, Inc.

  公开号：US10889593B2

  公开（公告）日：2021-01-12

  The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1α, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.

  本发明提供了调节蛋白质功能的化合物，以恢复蛋白质的平衡，包括细胞因子、CK1α、GSPT1、aiolos 和/或 ikaros 活性以及细胞-细胞粘附性。本发明提供了调节蛋白质介导的疾病，如细胞因子介导的疾病、失调、病症或反应的方法。本发明提供了组合物，包括与其他细胞因子和炎症介质的组合物。提供了治疗、改善或预防与蛋白质相关的疾病、失调或病症的方法，例如与细胞因子相关的疾病、失调和病症，包括炎症、纤维肌痛、类风湿性关节炎、骨关节炎、强直性脊柱炎、银屑病、银屑病关节炎、炎症性肠病、克罗恩病、溃疡性结肠炎、葡萄膜炎、炎症性肺病、慢性阻塞性肺病、阿尔茨海默病和癌症。
• COMPOUNDS TARGETING PROTEINS, COMPOSITIONS, METHODS, AND USES THEREOF
  申请人：BioTheryX, Inc.

  公开号：US20190322683A1

  公开（公告）日：2019-10-24

  The present invention provides compounds that modulate protein function, to restore protein homeostasis, including cytokine, CK1α, GSPT1, aiolos, and/or ikaros activity, and cell-cell adhesion. The invention provides methods of modulating protein-mediated diseases, such as cytokine-mediated diseases, disorders, conditions, or responses. Compositions, including in combination with other cytokine and inflammatory mediators, are provided. Methods of treatment, amelioration, or prevention of diseases, disorders, or conditions associated with a protein, such as diseases, disorders, and conditions associated with cytokines, including inflammation, fibromyalgia, rheumatoid arthritis, osteoarthritis, ankylosing spondylitis, psoriasis, psoriatic arthritis, inflammatory bowel diseases, Crohn's disease, ulcerative colitis, uveitis, inflammatory lung diseases, chronic obstructive pulmonary disease, Alzheimer's disease, and cancer, are provided.
• Amplification of Trichloroisocyanuric Acid (TCCA) Reactivity for Chlorination of Arenes and Heteroarenes via Catalytic Organic Dye Activation
  作者：David A. Rogers、Adam T. Bensalah、Alvaro Tomas Espinosa、John L. Hoerr、Fares H. Refai、Amy K. Pitzel、Juan J. Alvarado、Angus A. Lamar

  DOI：10.1021/acs.orglett.9b01414

  日期：2019.6.7

  electron-withdrawing groups are chlorinated in good to excellent yields (scalable to gram scale) using trichloroisocyanuric acid (TCCA) and catalytic Brilliant Green (BG). Visible-light activation of BG serves to amplify the electrophilic nature of TCCA, providing a mild alternative approach to acid-promoted chlorination of deactivated (hetero)aromatic substrates. The utility of the TCCA/BG system is demonstrated

  使用三氯异氰尿酸（TCCA）和催化艳绿（BG）以良好至极佳的收率（可缩放至克级）对含有吸电子基团的杂芳烃和芳烃进行氯化处理。BG的可见光活化可增强TCCA的亲电性质，为失活的（杂）芳族底物的酸促进氯化提供了温和的替代方法。通过与其他氯化试剂进行比较以及对包括咖啡因，利多卡因和非那酮在内的药物进行氯化，证明了TCCA / BG系统的实用性。