2-(氨基甲基)-5-甲基苯酚 | 40680-68-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(氨基甲基)-5-甲基苯酚
• 英文名称: 2-Aminomethyl-5-methyl-phenol
• 英文别名: 2-(Aminomethyl)-5-methylphenol
• CAS: 40680-68-0
• 化学式: C₈H₁₁NO
• 分子量: 137.181
• InChiKey: WNSXEDPCKDOJQN-UHFFFAOYSA-N

物化性质

• 沸点：
  263.4±25.0 °C(Predicted)
• 密度：
  1.105±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  10
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-(氨基甲基)-5-甲基苯酚 在 氯仿 、 溴 作用下， 生成 6-aminomethyl-2,4-dibromo-3-methyl-phenol
  参考文献：
  名称：

  Oshima, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1942, vol. 45, p. 1194,1199

  摘要：

  DOI：
• 作为产物：
  描述：

  2-羟基-4-甲基苯甲醛肟 在 sodium amalgam 、 溶剂黄146 作用下， 生成 2-(氨基甲基)-5-甲基苯酚
  参考文献：
  名称：

  Oshima, Kogyo Kagaku zasshi / Journal of the Society of Chemical Industry, 1942, vol. 45, p. 1194,1199

  摘要：

  DOI：

文献信息

• Purine compounds, process for their preparation and pharmaceutical compositions
  申请人：SMITH KLINE & FRENCH LABORATORIES LIMITED

  公开号：EP0352960A2

  公开（公告）日：1990-01-31

  Compounds of the formula (1): and pharmaceutically acceptable salts thereof, wherein R¹ is C???alkyl, C???alkenyl, C???cycloalkylC???alkyl, phenylC???alkyl or C???alkyl substituted by 1 to 6 fluoro groups; R² is hydrogen, hydroxy, C???alkyl, phenyl, mercapto, C???alkylthio, CF? or amino; R³ is hydrogen, nitro, amino, C???alkanoylamino, C???­alkoxy, C???alkyl, halo, SO?NR?R?, CONR?R?, cyano or C???alkylS(O)n; R? and R? are independently hydrogen or C???alkyl; and n is 0, 1 or 2; provided that R³ is not hydrogen when R¹ is C???alkyl or C???alkenyl and R² is hydrogen or hydroxy. Processes for their preparation, pharmaceutical compositions comprising them and their use as medicaments are described.

  式（1）的化合物： 及其药学上可接受的盐，其中 R¹ 是 C???烷基、C???烯基、C???环烷基 C???烷基、苯基 C???烷基或被 1 至 6 个氟基团取代的 C??烷基； R² 是氢、羟基、C??烷基、苯基、巯基、C??烷硫基、CF?或氨基； R³ 是氢、硝基、氨基、C???烷酰氨基、C???烷氧基、C??烷基、卤素、SO?NR?R?、CONR?R?、氰基或 C??烷基S(O)n； R? 和 R? 独立地为氢或 C??烷基；以及 n 是 0、1 或 2； 当 R¹ 为 C???烷基或 C???烯基，且 R² 为氢或羟基时，R³ 不是氢。本文介绍了它们的制备方法、包含它们的药物组合物以及它们作为药物的用途。
• Compounds for inhibiting bacterial growth via phosphatidylglycerol binding
  申请人：Wichita State University

  公开号：US10668048B2

  公开（公告）日：2020-06-02

  Antibacterial small molecule compounds, termed liptins, bind to phosphatidylglycerol in bacterial plasma membranes. The small molecule compounds comprise a three-dimensional complementary binding pocket for phosphatidylglycerol, disrupting membrane function in a bacteriostatic or bactericidal manner. Methods of inhibiting bacterial growth and/or treating Gram-positive or Gram-negative bacterial infection using such compounds are also disclosed.

  抗菌小分子化合物被称为脂蛋白，可与细菌质膜中的磷脂酰甘油结合。 小分子化合物包含一个三维互补的磷脂酰甘油结合袋，以抑菌或杀菌的方式破坏膜功能。 还公开了使用此类化合物抑制细菌生长和/或治疗革兰氏阳性或革兰氏阴性细菌感染的方法。
• COMPOUNDS FOR INHIBITING BACTERIAL GROWTH VIA PHOSPHATIDYLGLYCEROL BINDING
  申请人：Wichita State University

  公开号：EP3408270B1

  公开（公告）日：2021-12-15
• LEVUGLANDIN ADDUCTS HISTONE H4 IN A CYCLOOXYGENASE-2-DEPENDENT MANNER, ALTERING ITS INTERACTION WITH DNA
  申请人：VANDERBILT UNIVERSITY

  公开号：US20150265584A1

  公开（公告）日：2015-09-24

  Method of inhibiting formation of levuglandin adducts of histone and DNA in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.
• COMPOUNDS AND METHODS FOR SCAVENGING DICARBONYL ELECTROPHILES
  申请人：VANDERBILT UNIVERSITY

  公开号：US20200383938A1

  公开（公告）日：2020-12-10

  Compounds and methods of scavenging bifunctional electrophiles and reducing the occurrence of lysyl-levuglandin adducts in a subject in need thereof by administering a levuglandin adduct formation inhibiting amount of a compound of the following formula: wherein the variables are defined herein.