N-methyl-N-(2-methoxybenzoyl)hydroxylamine | 63977-15-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-methyl-N-(2-methoxybenzoyl)hydroxylamine
• 英文别名: N-Methyl-o-methoxybenzohydroxamic acid；N-hydroxy-2-methoxy-N-methylbenzamide；2-Methoxy-N-methylbenzohydroxamsaeure
• CAS: 63977-15-1
• 化学式: C₉H₁₁NO₃
• 分子量: 181.191
• InChiKey: OUIBYXBQHNVFJX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  N-methyl-N-(2-methoxybenzoyl)hydroxylamine 在 劳森试剂 、 sodium hydroxide 、 molecular sieve 、 碳酸氢钠 作用下， 以 四氢呋喃 、 二氯甲烷 为溶剂， 反应 18.0h， 生成 N-Hydroxy-2-methoxy-N-methyl-thiobenzamide
  参考文献：
  名称：

  A Convenient Method for the Synthesis ofN-Hydroxythiobenzamides (C-Arylthiohydroxamic Acids)

  摘要：

  DOI：

  10.1055/s-1984-30981
• 作为产物：
  描述：

  N-甲基羟胺 、 甲氧基苯甲酰氯 在 碳酸氢钠 作用下， 以 甲醇 、 乙醚 为溶剂， 以69%的产率得到N-methyl-N-(2-methoxybenzoyl)hydroxylamine
  参考文献：
  名称：

  Triorganotin(IV) complexes with o-substituted arylhydroxamates: Synthesis, spectroscopic characterization, X-ray structures and in vitro cytotoxic activities

  摘要：

  Six new triorganotin(IV) complexes with six different RN-2-X-benzohydroxamic acid ligands having general formula R'C(O)N(RN)OH (R' = alkyl/aryl; RN = alkyl/aryl or H), (X = -I, -NO2, -OCH3, -Br and R = -CH3, -C6H5 and -C6H4-CH3), were prepared by condensation method with the respective organotin(IV) chlorides using a stoichiometric ratio of 1:1. The bonding and coordination behaviour of these complexes were investigated on the basis of FT-IR, multinuclear H-1, C-13 and Sn-119 NMR spectroscopies. Complexes (1) and (3) crystallize in the orthorhombic P2(1)2(1)2(1) space group and complex (2) crystallizes in the triclinic P-1 space group whereas complex (4) crystallizes in the monoclinic P2(1)/c space group. The tested triphenyltin(IV) complexes showed significant cytotoxicities, higher than doxorubicin toward K-562, Jurkat, HepG2 and L929 cells. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.jorganchem.2014.04.015

文献信息

• 一种含吡啶羟胺类化合物、制备方法及其用途
  申请人：中国科学院上海有机化学研究所

  公开号：CN103992304B

  公开（公告）日：2016-09-14

  本发明是一种含吡啶羟胺类化合物，制备方法以及用途。其结构通式如下：在结构通式(I)中：R1选自C1‑C4烷基；R2选自C3‑C6环烷基、取代苯基、取代杂环基；X选自氢、三氟甲基或卤素。主要用于农用杀菌剂。
• Benzohydroxamic acids as potent and selective anti-HCV agents
  作者：Maxim V. Kozlov、Alla A. Kleymenova、Lyudmila I. Romanova、Konstantin A. Konduktorov、Olga A. Smirnova、Vladimir S. Prasolov、Sergey N. Kochetkov

  DOI：10.1016/j.bmcl.2013.08.081

  日期：2013.11

  A diverse collection of 40 derivatives of benzohydroxamic acid (BHAs) of various structural groups were synthesized and tested against hepatitis C virus (HCV) in full-genome replicon assay. Some of these compounds demonstrated an exceptional activity, suppressing viral replication at sub-micromolar concentrations. The compounds were inactive against key viral enzymes NS3, and NS5B in vitro assays, suggesting host cell inhibition target(s). The testing results were consistent with metal coordination by the BHAs hydroxamic group in complex with a target(s). Remarkably, this class of compounds did not suppress poliomyelitis virus (PV) propagation in RD cells indicating a specific antiviral activity of BHAs against HCV. (C) 2013 Elsevier Ltd. All rights reserved.
• Preparation and properties of N-methyl- and N-(4-chlorophenyl)-substituted hydroxamic acids
  作者：Tilak R. Choudhary、Shiv G. Tandon

  DOI：10.1021/je00040a035

  日期：1985.4
• LOBO, A. M.;PRABHAKAR, S.;TAVARES, M. R., TETRAHEDRON LETT., 1981, 22, N 31, 3007-3008
  作者：LOBO, A. M.、PRABHAKAR, S.、TAVARES, M. R.

  DOI：——

  日期：——
• PRABHAKAR, SUNDARESAN;LOBO, A. M.;SANTOS, M. A.;RZEPA, H. S., SYNTHESIS, BRD, 1984, N 10, 829-831
  作者：PRABHAKAR, SUNDARESAN、LOBO, A. M.、SANTOS, M. A.、RZEPA, H. S.

  DOI：——

  日期：——