N-sec-butyl-N-methyl-aniline | 17693-27-5

• 分子结构分类: 有机化合物 - 有机氮化合物
• 英文名称: N-sec-butyl-N-methyl-aniline
• 英文别名: N-sec-Butyl-N-methyl-anilin；N-Methyl-N-sek.-butyl-anilin；N-(2-Butyl)-N-methyl-anilin；aniline, N-s-butyl-N-methyl-；N-butan-2-yl-N-methylaniline
• CAS: 17693-27-5
• 化学式: C₁₁H₁₇N
• 分子量: 163.263
• InChiKey: REFGXLSOFBWGAQ-UHFFFAOYSA-N

物化性质

• 沸点：
  109-110 °C(Press: 12 Torr)
• 密度：
  0.920±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  N-sec-butyl-N-methyl-aniline 在 盐酸 、 sodium nitrite 作用下， 生成 N-sec-butyl-N-methyl-p-phenylenediamine
  参考文献：
  名称：

  van Hoek et al., Recueil des Travaux Chimiques des Pays-Bas, 1958, vol. 77, p. 559,565

  摘要：

  DOI：
• 作为产物：
  描述：

  邻溴氟苯 在 铂 氢气 作用下， 生成 N-sec-butyl-N-methyl-aniline
  参考文献：
  名称：

  Hellmann,H.; Scheytt,G.M., Justus Liebigs Annalen der Chemie, 1961, vol. 642, p. 22 - 27

  摘要：

  DOI：

文献信息

• Carbostyril compound
  申请人：Kuroda Takeshi

  公开号：US20070179173A1

  公开（公告）日：2007-08-02

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的碳基噻吩化合物或其盐，其中A是直接键，较低的烷基烷基或较低的烷基亚烷基；X是氧原子或硫原子；R4和R5分别表示氢原子；碳基噻吩骨架的3和4位之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的碳基噻吩化合物或其盐能够诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和伤口等疾病。
• CARBOSTYRIL COMPOUND
  申请人：Kuroda Takeshi

  公开号：US20100261705A1

  公开（公告）日：2010-10-14

  The present invention provides a carbostyril compound represented by General Formula (1) or a salt thereof, wherein A is a direct bond, a lower alkylene group, or a lower alkylidene group; X is an oxygen atom or a sulfur atom; R 4 and R 5 each represent a hydrogen atom; the bond between the 3 and 4 positions of the carbostyril skeleton is a single bond or a double bond; R 1 is a hydrogen atom, etc; R 2 is a hydrogen atom, etc; and R 3 is a hydrogen atom, etc. The carbostyril compound or salt thereof of the present invention induces the production of TFF, and thus is usable for the treatment and/or prevention of disorders such as alimentary tract diseases, oral diseases, upper respiratory tract diseases, respiratory tract diseases, eye diseases, cancers, and wounds.

  本发明提供了一种由通式（1）表示的羧基苯基咔唑化合物或其盐，其中A表示直接键，较低的烷基烷基或较低的烷基亚甲基烷基；X表示氧原子或硫原子；R4和R5各代表氢原子；羧基苯基咔唑骨架的3和4位置之间的键是单键或双键；R1是氢原子等；R2是氢原子等；R3是氢原子等。本发明的羧基苯基咔唑化合物或其盐可诱导TFF的产生，因此可用于治疗和/或预防消化道疾病、口腔疾病、上呼吸道疾病、呼吸道疾病、眼部疾病、癌症和创伤等疾病。
• PYRIMIDINE OR PYRIDINE COMPOUNDS, PREPARATION METHOD THEREFOR AND PHARMACEUTICAL USES THEREOF
  申请人：Shanghai Shaletech Technology Co., Ltd.

  公开号：EP3216786A1

  公开（公告）日：2017-09-13

  The present invention disclosed a class of pyrimidine or pyridine compounds, pharmaceutically acceptable salts, stereoisomers, prodrugs and solvates thereof, preparation method therefor and pharmaceutical compositions and pharmaceutical uses thereof. The compounds can inhibit the variants of EGFR (Epidermis Growth Factor Receptor) proteinases, and therefore can inhibit the growth of a variety of tumor cells effectively. The compounds can be used to prepare antitumor drugs, used for the treatment, combined therapy or prevention of various different cancers. The compounds can overcome the drug resistance induced by the existing first-generation EGFR inhibitors such as gefitinib, erlotinib and so on. Particularly, the compounds can be used to prepare drugs for treating or preventing diseases, disturbances, disorders or conditions mediated by epidermis growth factor receptor variants (such as L858R activated mutants, Exon19 deletion activated mutants and T790M resistant mutants).

  本发明公开了一类嘧啶或吡啶化合物、其药学上可接受的盐、立体异构体、原药和溶液、其制备方法和药物组合物及其药物用途。这些化合物可以抑制表皮生长因子受体蛋白酶的变体，从而有效抑制多种肿瘤细胞的生长。这些化合物可用于制备抗肿瘤药物，用于治疗、联合治疗或预防各种不同的癌症。这些化合物可以克服现有的第一代表皮生长因子受体抑制剂（如吉非替尼、厄洛替尼等）引起的耐药性。特别是，这些化合物可用于制备治疗或预防由表皮生长因子受体变体（如 L858R 激活突变体、Exon19 缺失激活突变体和 T790M 耐药突变体）介导的疾病、紊乱、失调或病症的药物。
• Organoaminosilanes and methods for making same
  申请人：Versum Materials US, LLC

  公开号：US10294250B2

  公开（公告）日：2019-05-21

  Organoaminosilanes, such as without limitation di-iso-propylaminosilane (DIPAS), are precursors for the deposition of silicon containing films such as silicon-oxide and silicon-nitride films. Described herein are methods to make organoaminosilane compounds, or other compounds such as organoaminodisilanes and organoaminocarbosilanes, via the catalytic hydrosilylation of an imine by a silicon source comprising a hydridosilane.

  有机氨基硅烷，例如但不限于二异丙氨基硅烷（DIPAS），是沉积氧化硅和氮化硅薄膜等含硅薄膜的前体。本文描述了通过包含氢基硅烷的硅源对亚胺进行催化氢硅烷化来制造有机氨基硅烷化合物或其他化合物如有机氨基二硅烷和有机氨基碳硅烷的方法。
• CYANINE DYE COMPOUND AND PREPARATION METHOD THEREFOR, AND DUAL-FUNCTION AGENT FOR PHOTODYNAMIC THERAPY AND PREPARATION METHOD THEREFOR
  申请人：Zhejiang Hisun Pharmaceutical Co. Ltd.

  公开号：EP2940021B1

  公开（公告）日：2018-06-13