1,3-diethoxy-1-phenylpropane | 87175-99-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1,3-diethoxy-1-phenylpropane
• 英文别名: 1,3-Diaethoxy-1-phenyl-propan；(1,3-Diethoxypropyl)benzene；1,3-diethoxypropylbenzene
• CAS: 87175-99-3
• 化学式: C₁₃H₂₀O₂
• 分子量: 208.301
• InChiKey: NHBLXQCWWGMAIZ-UHFFFAOYSA-N

物化性质

• 沸点：
  167-168 °C(Press: 75 Torr)
• 密度：
  0.944 g/cm3(Temp: 22 °C)

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  15
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  苯甲醛二乙缩醛 在 lithium aluminium tetrahydride 、 对甲苯磺酸 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 40.0h， 生成 1,3-diethoxy-1-phenylpropane
  参考文献：
  名称：

  Additions of 1-(.alpha.-alkoxybenzyl)benzotriazoles to enol ethers. New routes to 1,3-diethers

  摘要：

  1-(alpha-Alkoxybenzyl)benzotriazoles undergo reversible ionization in solution to a benzotriazolyl anion (Bt-) and carboxonium cations PhCH:O+R. These cations can attack the beta-carbon atom of enol ethers to give cation adducts which add the Bt- to form new alpha-(benzotriazol-1-yl)alkyl ethers in which the carbon chains are extended by an alpha-ethoxybenzyl group. Reactions of these adducts with Grignard reagents produce the corresponding 1,3-diethers in high yield. Reduction of the adducts with lithium aluminum hydride gives the corresponding diethers via substitution of the benzotriazolyl moiety with a hydrogen atom or 1-(3-alkoxyalkyl)benzotriazoles via substitution of the alpha-alkoxy group, depending on the reaction conditions and the nature of the adduct.

  DOI：

  10.1021/jo00044a030

文献信息

• 9,10-DICYANOANTHRACENE-SENSITIZED TWO-ELECTRON OXIDATION OF PHENYLCYCLOPROPANE AND AROMATIC OLEFINS IN THE PRESENCE OF COPPER(II) ION
  作者：Kazuhiko Mizuno、Katsutoshi Yoshioka、Yoshio Otsuji

  DOI：10.1246/cl.1983.941

  日期：1983.6.5

  The photooxidation of phenylcyclopropane, styrene, and indene using 9,10-dicyanoanthracene-Cu(BF4)2 sensitizer system in acetonitrile-alcohol(3:1) solutions affords the corresponding 1,3-dialkoxy and 1,2-dialkoxy compounds.

  在乙腈-醇 (3:1) 溶液中使用 9,10-二氰基蒽-Cu(BF4)2 敏化剂体系对苯基环丙烷、苯乙烯和茚进行光氧化，得到相应的 1,3-二烷氧基和 1,2-二烷氧基化合物。
• The Condensation of Methylal and Other Acetals with Olefins¹
  作者：O. C. Dermer、John J. Hawkins

  DOI：10.1021/ja01138a044

  日期：1952.9
• Additions of 1-(.alpha.-alkoxybenzyl)benzotriazoles to enol ethers. New routes to 1,3-diethers
  作者：Alan R. Katritzky、Stanislaw Rachwal、Bogumila Rachwal、Peter J. Steel

  DOI：10.1021/jo00044a030

  日期：1992.8

  1-(alpha-Alkoxybenzyl)benzotriazoles undergo reversible ionization in solution to a benzotriazolyl anion (Bt-) and carboxonium cations PhCH:O+R. These cations can attack the beta-carbon atom of enol ethers to give cation adducts which add the Bt- to form new alpha-(benzotriazol-1-yl)alkyl ethers in which the carbon chains are extended by an alpha-ethoxybenzyl group. Reactions of these adducts with Grignard reagents produce the corresponding 1,3-diethers in high yield. Reduction of the adducts with lithium aluminum hydride gives the corresponding diethers via substitution of the benzotriazolyl moiety with a hydrogen atom or 1-(3-alkoxyalkyl)benzotriazoles via substitution of the alpha-alkoxy group, depending on the reaction conditions and the nature of the adduct.