N-chloro-p-toluidine | 57217-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-chloro-p-toluidine
• 英文别名: N-chlorotoluidine；chlorotoluidine；Benzenamine, N-chloro-4-methyl-；N-chloro-4-methylaniline
• CAS: 57217-98-8
• 化学式: C₇H₈ClN
• 分子量: 141.6
• InChiKey: LPEZIAPDJJLVHP-UHFFFAOYSA-N

物化性质

• 沸点：
  194.6±33.0 °C(Predicted)
• 密度：
  1.179±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  12
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  乙烷,三氯氟- 生成 N-chloro-p-toluidine
  参考文献：
  名称：

  Synthesis of oxindoles from anilines and .beta.-thio carboxylic esters

  摘要：

  通过将N-卤代苯胺与.beta.-硫酯或.beta.-硫酰胺反应以形成氮硫杂环卤化物，将氮硫杂环卤化物与碱反应以形成正交-[硫醚（烃氧羰基）烷基]苯胺或[硫醚（氨基羰基）烷基]苯胺，将正交取代苯胺与酸反应以形成3-硫醚-2-吲哚酮，然后使用Raney镍还原3-硫醚-2-吲哚酮以形成2-吲哚酮。

  公开号：

  US03972894A1

文献信息

• Process for producing azasulfonium salts and rearrangement thereof to
  申请人：The Ohio State University Research Foundation

  公开号：US03985756A1

  公开（公告）日：1976-10-12

  Preparing ortho-substituted anilines by reacting an N-chloroaniline with a non-carbonylic di-hydrocarbon sulfide to form an azasulfonium chloride, reacting the azasulfonium chloride with a strong base to form an aniline substituted in the 2-position with a hydrocarbon-S-hydrocarbyl thio-ether group. The ortho-substituted thio-ether compounds can be reduced with a de-sulfurizing reducing agent such as Raney nickel or the like to form the ortho-alkylated aniline. The aniline may be an amino-pyridine. The azasulfonium salt and thio-ether intermediate products can be isolated and recovered. If desired, the thio-ether compounds can be reduced to form ortho-alkylated aniline products which are useful as intermediates for a wide variety of purposes, including their uses in making dyes, herbicides, and the like.

  通过将N-氯苯胺与非酮二烃硫化物反应，形成_azasulfonium_氯化物，将_azasulfonium_氯化物与强碱反应，在2位上带有烃基-S-烃基硫醚基团的苯胺。这种正构硫醚化合物可以用脱硫还原剂如Raney镍等还原，形成正构烷基化苯胺。苯胺可以是氨基吡啶。可以分离和回收_azasulfonium_盐和硫醚中间体。如果需要，硫醚化合物可以还原形成正构烷基化苯胺产品，这些产品可用作多种用途的中间体，包括用于制造染料、除草剂等。
• [EN] CYSTATHIONINE-Y-GAMMA-LYASE (CSE) INHIBITORS<br/>[FR] INHIBITEURS DE LA CYSTATHIONINE-Y-GAMMA-LYASE (CSE)
  申请人：SOVA PHARMACEUTICALS INC

  公开号：WO2014018569A1

  公开（公告）日：2014-01-30

  Described herein are compounds and pharmaceutical compositions containing such compounds which inhibit cystathionine-γ- lyase (CSE). Also described herein are methods for using such CSE inhibitors, alone or in combination with other compounds, for treating diseases or conditions that would benefit from CSE inhibition.

  本文描述了抑制半胱氨酸-γ-裂解酶（CSE）的化合物和含有这些化合物的药物组合物。本文还描述了使用这些CSE抑制剂的方法，单独或与其他化合物结合，用于治疗需要CSE抑制的疾病或症状。
• ORGANIC ELECTROLUMINESCENCE DEVICE AND AMINE COMPOUND FOR ORGANIC ELECTROLUMINESCENCE DEVICE
  申请人：Samsung Display Co., Ltd.

  公开号：US20210175430A1

  公开（公告）日：2021-06-10

  An organic electroluminescence device includes a first electrode, a second electrode facing the first electrode, and a plurality of organic layers between the first electrode and the second electrode, wherein at least one of the plurality of organic layers includes an amine compound, the amine compound includes a central nitrogen atom, a carbazole group substituted to the central nitrogen atom, and a dibenzoselenophene group substituted to the central nitrogen atom, and a nitrogen atom of the carbazole group is substituted with a substituted or unsubstituted aryl group or a substituted or unsubstituted heteroaryl group. The organic electroluminescence device thereby has high efficiency and long-life.

  一种有机电致发光器件包括第一电极，面向第一电极的第二电极，以及位于第一电极和第二电极之间的多个有机层，其中多个有机层中至少有一层包括胺化合物，该胺化合物包括中心氮原子、取代于中心氮原子的碳酰胺基团和取代于中心氮原子的二苯硒吩基团，碳酰胺基团的氮原子被取代为取代或未取代的芳基团或取代或未取代的杂环芳基团。因此，该有机电致发光器件具有高效率和长寿命。
• Separation of amine from a phenolic compound
  申请人：Renner A. Carl

  公开号：US20050080294A1

  公开（公告）日：2005-04-14

  A process comprises contacting a product mixture with a base, optionally in the presence of a polyhydric alcohol, to produce a base-treated mixture and distilling the base-treated mixture in which the product mixture comprises an aromatic amine and a phenolic compound.

  一个过程包括将产品混合物与碱接触，可选地在多元醇的存在下，以产生经碱处理的混合物，并蒸馏经碱处理的混合物，其中产品混合物包括芳香胺和酚化合物。
• N-alkyl-N-(Aminophenylsulfonyl)-aminoalkylphosphonic acids and salts
  申请人：CROMPTON & KNOWLES CORPORATION

  公开号：EP0385010A1

  公开（公告）日：1990-09-05

  This invention relates to novel N-alkyl-N-(amino-phenylsulfonyl)-aminoalkylphosphonic acids and to processes for their preparation. These compounds are useful as intermediates, especially for the manufacture of dyes containing phosphonic acid groups in their structure. Such dyes are reactive with cellulosic fibers and fabrics in the presence of carbodiimides at elevated temperatures.

  本发明涉及新型N-烷基-N-(氨基苯磺酰基)-氨基烷基膦酸以及它们的制备方法。这些化合物可用作中间体，尤其适用于制造含有膦酸基团的染料。这些染料在存在卡波二亚胺的情况下，在高温下与纤维素纤维和织物反应。