2-(5-chloro-2-methoxy-benzoyl)-benzoic acid | 92428-46-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(5-chloro-2-methoxy-benzoyl)-benzoic acid
• 英文别名: 2-(5-Chlor-2-methoxy-benzoyl)-benzoesaeure；2-<5-Chlor-2-methoxy-benzoyl>-benzoesaeure；2-(3-Chloro-6-methoxybenzoyl)benzoic acid；2-(5-chloro-2-methoxybenzoyl)benzoic acid
• CAS: 92428-46-1
• 化学式: C₁₅H₁₁ClO₄
• 分子量: 290.703
• InChiKey: OFGDXYRZFLHGGB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.4
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-(氯羰基)苯甲酸甲酯 在 三氯化铝 作用下， 生成 2-(5-chloro-2-methoxy-benzoyl)-benzoic acid
  参考文献：
  名称：

  Methadone is safe for treating hospitalized patients with severe pain

  摘要：

  Purpose: Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients. The infrequent use of methadone is probably due to its long plasma half-life that could lead to accumulation and toxicity. In the present study we report that clinically effective analgesic doses of methadone, given either epidurally or orally, can be used safely for prolonged treatment in hospitalized patients.Clinical features: Over a five-year period we administered methadone at Hadassah Hospital in Jerusalem to 3,954 in-patients with severe pain, 12% of whom were younger than 17 yr. Satisfactory pain relief was recorded in more than 85% of the patients. None of the patients treated with oral methadone developed serious side effects. Three patients, treated with epidural methadone (0.09%), developed a clinically significant respiratory depression, In all three cases, epidural pump failure or pump misprogramming resulted in methadone overdose, None of the children or adults treated with methadone developed addiction during hospitalization.Conclusion: Based on its analgesic properties and marked safety profile, we suggest that methadone could be added to the analgesic armamentarium of in-hospital health-care providers. Moreover, methadone could serve as the opioid of first choice in some inpatient populations.

  DOI：

  10.1007/bf03020377

文献信息

• Methadone is safe for treating hospitalized patients with severe pain
  作者：Yoram Shir、Gila Rosen、Alexander Zeldin、Elyad M. Davidson

  DOI：10.1007/bf03020377

  日期：2001.12

  Purpose: Methadone is still regarded as a second line opioid for patients suffering from severe pain, and is rarely used in hospitalized patients. The infrequent use of methadone is probably due to its long plasma half-life that could lead to accumulation and toxicity. In the present study we report that clinically effective analgesic doses of methadone, given either epidurally or orally, can be used safely for prolonged treatment in hospitalized patients.Clinical features: Over a five-year period we administered methadone at Hadassah Hospital in Jerusalem to 3,954 in-patients with severe pain, 12% of whom were younger than 17 yr. Satisfactory pain relief was recorded in more than 85% of the patients. None of the patients treated with oral methadone developed serious side effects. Three patients, treated with epidural methadone (0.09%), developed a clinically significant respiratory depression, In all three cases, epidural pump failure or pump misprogramming resulted in methadone overdose, None of the children or adults treated with methadone developed addiction during hospitalization.Conclusion: Based on its analgesic properties and marked safety profile, we suggest that methadone could be added to the analgesic armamentarium of in-hospital health-care providers. Moreover, methadone could serve as the opioid of first choice in some inpatient populations.