2-oxo-5t-phenyl-pent-4-enoic acid ethyl ester | 15504-36-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-oxo-5t-phenyl-pent-4-enoic acid ethyl ester
• 英文别名: 2-Oxo-5t-phenyl-pent-4-ensaeure-aethylester；ethyl (E)-2-oxo-5-phenylpent-4-enoate
• CAS: 15504-36-6
• 化学式: C₁₃H₁₄O₃
• 分子量: 218.252
• InChiKey: AAPIGOXSODFWMJ-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  16
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  43.4
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• [EN] PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF<br/>[FR] DERIVES D'ACIDE PENTENOIQUE, PROCEDES DE PREPARATION DE CES DERIVES, COMPOSITIONS PHARMACEUTIQUES LES CONTENANT ET APPLICATIONS THERAPEUTIQUES ASSOCIEES
  申请人：MERCK PATENT GMBH

  公开号：WO2005105723A1

  公开（公告）日：2005-11-10

  Compounds of the formula (I): in which R, R1, R2 and R3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.

  化合物的公式（I）：其中R，R1，R2和R3如说明中所定义，用于治疗失调脂质症，动脉粥样硬化和糖尿病，制备这些化合物的药物组合物以及制备这些化合物的过程。
• PENTENOIC ACID DERIVATIVES, PROCESSES FOR THE PREPARATION THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, AND THERAPEUTIC APPLICATIONS THEREOF
  申请人：Merck Patent GmbH

  公开号：EP1742903B1

  公开（公告）日：2007-08-22
• Pentenoic Acid Derivatives, Processes For The Preparation Thereof, Pharmaceutical Compositions Comprising Them, And Therapeutic Applications Thereof
  申请人：Zeiller Jacques Jean

  公开号：US20080015253A1

  公开（公告）日：2008-01-17

  Compounds of the formula (I): in which R, R 1 , R 2 and R 3 are as defined in the description, to their use for the treatment of dyslipidaemia, atherosclerosis and diabetes, to pharmaceutical compositions comprising them and to the processes for the preparation of these compounds.
• US7465752B2
  申请人：——

  公开号：US7465752B2

  公开（公告）日：2008-12-16