3-phenylpentanamine | 89538-62-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-phenylpentanamine
• 英文别名: 3-ethyl-3-phenyl-propylamine；3-Phenyl-pentylamin；3-phenylpentan-1-amine
• CAS: 89538-62-5
• 化学式: C₁₁H₁₇N
• 分子量: 163.263
• InChiKey: SVPJLIYAHZYRGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  12
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-phenylpentanamine 在 吡啶 、 盐酸 作用下， 以 二氯甲烷 为溶剂， 反应 2.25h， 生成 N-[3-(1H-Imidazol-4-yl)-propyl]-N'-(3-phenyl-pentyl)-guanidine; hydrochloride
  参考文献：
  名称：

  Synthesis and histamine H2 agonistic activity of arpromidine analogues: replacement of the pheniramine-like moiety by non-heterocyclic groups

  摘要：

  Analogues of the potent histamine H-2 agonist arpromidine, characterized by non-heterocyclic groups (phenyl, cyclo-hexyl, alkyl) instead of the pheniramine-like portion, were prepared and tested for their H-2 agonistic and H-1 antagonistic activity in the isolated guinea pig right atrium and ileum, respectively. In the diphenylpropylguanidine series an increase in H-2 agonistic potency resulted from mono- or difluorination at one or both phenyl rings in the meta and/or para position (pD2 less-than-or-equal-to 7.75 vs pD2 = 7.15 for the unsubstituted parent compound). Compounds chlorinated at both phenyl rings were considerably less potent. Highest combined H-2 agonistic/H-1 antagonistic potency was found in the 4-fluorophenyl series. The arpromidine analogue with cyclohexyl and methyl group instead of phenyl and pyridine ring proved to be 30 times more potent than histamine in the atrium. The H-1 antagonistic potency in cyclohexyl compounds was lower than in the diaryl series. Thus, aromatic rings appear not to be required for high H-2 agonistic potency but are useful for combined H-2 agonistic/H-1 antagonistic activity.

  DOI：

  10.1016/0223-5234(92)90145-q
• 作为产物：
  描述：

  3-苯基戊酸 在 lithium aluminium tetrahydride 、 氯化亚砜 、 氨 作用下， 生成 3-phenylpentanamine
  参考文献：
  名称：

  Testa,E. et al., Justus Liebigs Annalen der Chemie, 1964, vol. 673, p. 60 - 70

  摘要：

  DOI：

文献信息

• [EN] SUBSTITUTED SULFONAMIDE DERIVATIVES<br/>[FR] DÉRIVÉS SUBSTITUÉS DE SULFONAMIDE
  申请人：GRUENENTHAL GMBH

  公开号：WO2009124746A1

  公开（公告）日：2009-10-15

  The invention relates to substituted sulfonamide derivatives, processes for the preparation thereof, medicaments containing these compounds and the use of substituted sulfonamide derivatives for the preparation of medicaments.

  这项发明涉及替代磺胺基衍生物，其制备方法，含有这些化合物的药物以及利用替代磺胺基衍生物制备药物。
• Fungicidal N-substituted maleic acid imides
  申请人：Bayer Aktiengesellschaft

  公开号：US04582849A1

  公开（公告）日：1986-04-15

  Fungicidally active substituted maleic acid amides of the formula ##STR1## in which X is hydrogen, chlorine or bromine, X.sup.1 is chlorine or bromine, R is alkyl, optionally substituted aryl or optionally substituted aralkyl, R.sup.1 to R.sup.5 each independently is hydrogen, alkyl, optionally substituted aryl or optionally substituted aralkyl, R.sup.6 each independently is halogen, alkyl, optionally substituted aryl, optionally substituted cycloalkyl, alkoxy, sulphonylamine, halogenoalkyl, nitro, cyano, alkoxycarbonyl, alkylsulphonyl or carboxylamine, n is 0, 1, 2 or 3, m is 0, 1, 2 or 3, m+n is 0, 1, 2 or 3, and y is 0, 1, 2, 3, 4 or 5, with the exception of the compound in which X and X.sup.1 are chlorine, m and y are 0, n is 1, R.sup.1, R.sup.4 and R.sup.5 are hydrogen, and R is methyl, and the compound in which X and X.sup.1 are chlorine, m, n and y are 0, R.sup.1 is hydrogen, and R is phenyl.

  化学式为##STR1##的替代马来酸酰胺具有真菌杀活性，其中X为氢、氯或溴，X.sup.1为氯或溴，R为烷基、可选取代芳基或可选取代芳基烷基，R.sup.1至R.sup.5各自独立地为氢、烷基、可选取代芳基或可选取代芳基烷基，R.sup.6各自独立地为卤素、烷基、可选取代芳基、可选取代环烷基、烷氧基、磺酰胺、卤代烷基、硝基、氰基、烷氧羰基、烷基磺酰或羧氨基，n为0、1、2或3，m为0、1、2或3，m+n为0、1、2或3，y为0、1、2、3、4或5，但X和X.sup.1为氯、m和y为0、n为1、R.sup.1、R.sup.4和R.sup.5为氢，R为甲基的化合物和X和X.sup.1为氯、m、n和y为0、R.sup.1为氢，R为苯基的化合物除外。
• PYRIMIDYL CYCLOPENTANES AS AKT PROTEIN KINASE INHIBITORS
  申请人：Banka Anna

  公开号：US20110053959A1

  公开（公告）日：2011-03-03

  The present invention provides compounds of Formula (I) including tautomers, resolved enantiomers, resolved diastereomers, solvates, metabolites, salts and pharmaceutically acceptable prodrugs thereof. Also provided are methods of using the compounds of this invention as Akt protein kinase inhibitors and for the treatment of Akt-mediated diseases, for example, hyperproliferative diseases such as cancer.

  本发明提供了公式（I）的化合物，包括互变异构体、分离的对映体、分离的二对映异构体、溶剂化物、代谢物、盐和其药学上可接受的前药。还提供了使用本发明化合物作为Akt蛋白激酶抑制剂和用于治疗Akt介导的疾病（例如，癌症等增殖性疾病）的方法。
• Cyclin Based Inhibitors of CDK2 and CDK4
  申请人：University of South Carolina

  公开号：US20150011730A1

  公开（公告）日：2015-01-08

  Structural and functional analysis of peptide inhibitor binding to the cyclin D and cyclin A groove has been investigated and used to design peptides that provide the basis for structure-activity relationships, have improved binding and have potential for development as chemical biology probes, as potential diagnostics and as therapeutics in the treatment of proliferative diseases including cancer and inflammation.

  对肽抑制剂与细胞周期素D和细胞周期素A凹槽的结构和功能分析已经进行了研究，并用于设计肽，为结构活性关系提供基础，具有改善结合能力并具有潜力作为化学生物学探针，潜在诊断工具和治疗增生性疾病，包括癌症和炎症。
• Quaternary ammonium salts, and their formulations and preparation
  申请人：ELI LILLY AND COMPANY

  公开号：EP0002604A1

  公开（公告）日：1979-06-27

  Novel quaternary ammonium salts of certain pheny-Ipropylamines and phenylbutylamines are disclosed. They are useful drugs for treating arrhythmia and prolonging the action potential of cardiac muscle. They are prepared by reacting a tertiary amine with an alkyl salt.

  本研究公开了某些苯基丙胺和苯基丁胺的新型季铵盐。它们是治疗心律失常和延长心肌动作电位的有用药物。它们是通过叔胺与烷基盐反应制备的。