3-methyl-4-(2-methylphenyl)aniline | 33384-13-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-methyl-4-(2-methylphenyl)aniline
• 英文别名: 2,2'-dimethyl-biphenyl-4-ylamine；2,2'-Dimethyl-biphenyl-4-ylamin；3-Methyl-4-(2-methyl-phenyl)-anilin；4-Amino-2,2'-dimethylbiphenyl
• CAS: 33384-13-3
• 化学式: C₁₄H₁₅N
• 分子量: 197.28
• InChiKey: SWOVFCCIZCCEGF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  26
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3-methyl-4-(2-methylphenyl)aniline 在 硫酸 、 铜 作用下， 生成 2,2',3'',2'''-tetramethyl-[1,1';4',1'';4'',1''']quaterphenyl
  参考文献：
  名称：

  Über die Synthese methylsubstituierter P-Oligopenylene. 5. Mitteilung

  摘要：

  AbstractUnsubstituierte p‐Oligophenylene sind sehr schwer löslich. Die Löslichkeit dieser substanzen kann durch Substitution mit Methylgruppen verbessert werden.Für die Synthese methylsubstituierter p‐Oligophenylence wurden verschiedene Verfahren herangezogen.Durch ULIMANN‐Kondensation entsprechender Jodaryle konnten zwei substitutionsisomere Tettamethyl‐p‐quaterphenyle, ein Tetramethoxy‐p‐quaterphenyl und ein Tetramethyl‐p‐sexiphenyl synthetisiert werden.Über die Carbonyladdition aromatischer metallorganischer Verbindungen an cyclische Diketone wurden über hydroaromatische Zwischenstufen ein Dimethyl‐p‐terphenyl, ein Tetramethyl‐p‐ quinquiphenul, zwei substitutionsisomere Dimethyl‐p‐quaterphenyle und ein Tetramethyl‐p‐sexiphenyl erhalten.Mit der N‐Nitroso‐acetylarylamin‐Reaktion gelang die Synthese eines weiteren Dimethyl‐p‐quaterpyenyls.An dem Dimethyl‐p‐terphenyl wurden elektrophile Substitutionsreaktionen studiert. Dabei ergab sich, daß die Substituenten bevorzugt die p‐Stellung aufsuchen.Die Bencnnung dieser Verbindungen wird nach einem neuen Bezifferungs‐Schema vorgenommen.Methylsubstituierte p‐Oligophenylene besitzen gegenüber den unsubstituierten Grundkörpern ausgeprägte LoUslichkeitseigenschaften. Der Löslichkeitsunterschied kann mehrere Zehnerpotenzen ausmachen.

  DOI：

  10.1002/macp.1959.020290115
• 作为产物：
  描述：

  2,2'-dimethylbenzidine dihydrochloride 在 盐酸 作用下， 生成 3-methyl-4-(2-methylphenyl)aniline
  参考文献：
  名称：

  Synthesis of 2,2′-Dimethyl-p-quaterphenyl

  摘要：

  DOI：

  10.1055/s-1971-35026

文献信息

• 방향족 아민 유도체 및 유기 전기발광 소자
  申请人：IDEMITSU KOSAN CO., LTD. 이데미쓰 고산 가부시키가이샤(519980963384)

  公开号：KR20160021123A

  公开（公告）日：2016-02-24

  본 발명의 목적은, 구동 전압을 저하시킴과 더불어, 장수명의 유기 EL 소자를 제공하는 것이다. 본 발명의 방향족 아민 유도체는, 하기 화학식(1)로 표시되고; 화학식(1)에 있어서, Ar 및 Ar는 아릴기 또는 헤테로아릴기이고; L 및 L는 단일 결합, 아릴렌기 또는 헤테로아릴렌기이고; R∼R는 알킬기, 아릴기, 헤테로아릴기, 알콕시기, 아르알킬기, 아릴옥시기, 아릴싸이오기, 알콕시카보닐기, 할로겐 원자, 사이아노기, 나이트로기, 실릴기, 하이드록실기 또는 카복실기이고; a 및 b는 0∼4의 정수이고; R∼R는 수소 원자, 알킬기, 아릴기, 헤테로아릴기 또는 실릴기이다. 단, R 및 R 중 적어도 어느 하나는 수소 원자는 아니고, R가 수소 원자가 아닌 경우는 R이 수소 원자는 아니며, R이 수소 원자가 아닌 경우는 R이 수소 원자는 아니다.

  本发明的目的是提供一种降低驱动电压并提供长寿命的有机EL器件。本发明的芳香胺衍生物表示为下述化学式(1)；在化学式(1)中，Ar和Ar分别表示芳基或杂芳基；L和L分别表示单键，芳基亚烯基或杂芳亚烯基；R∼R表示烷基，芳基，杂芳基，烷氧基，芳基氧基，芳基硫基，烷氧羰基，卤原子，氰基，硝基，硅烷基，羟基或羰基；a和b是0到4的整数；R∼R表示氢原子，烷基，芳基，杂芳基或硅基。但是，R和R中至少有一个不是氢原子，如果R不是氢原子，则R也不是氢原子，如果R不是氢原子，则R也不是氢原子。
• Development of antiproliferative phenylmaleimides that activate the unfolded protein response
  作者：Ulrike Muus、Curtis Hose、Wei Yao、Teresa Kosakowska-Cholody、David Farnsworth、Marzena Dyba、George T. Lountos、David S. Waugh、Anne Monks、Terrence R. Burke Jr.

  DOI：10.1016/j.bmc.2010.04.057

  日期：2010.6.15

  The current paper presents the synthesis and evaluation of a series of maleimides that were designed to inhibit the Cdc25 phosphatase by alkylation of catalytically essential cysteine residues. Although in HepB3 cell culture assays the analogues did exhibit antiproliferative IC50 values ranging from sub-micromolar to greater than 100 mu M, inhibition of Cdc25 through cysteine alkylation could not be demonstrated. It was also found that analysis using fluorescence activated cell sorting (FACS) following treatment with the most potent analogue (1t) did not provide data consistent with inhibition at one specific point in the cell cycle, as would be expected if Cdc25A were inhibited. Further studies with a subset of analogues resulted in a correlation of antiproliferative potencies with activation of the unfolded protein response (UPR). The UPR is a regulatory pathway that temporarily suspends protein production when misfolding of proteins occurs within the endoplastic reticulum(ER). In addition, ER chaperones that promote proper refolding become up-regulated. If cellular damage cannot be resolved by these mechanisms, then the UPR can initiate apoptosis. The current study indicates that these maleimide analogues lead to UPR activation, which is predictive of the selective antiproliferative activity of the series. Published by Elsevier Ltd.
• MULTIMERIC MAGENTIC RESONANCE CONTRAST AGENTS
  申请人：GE Healthcare AS

  公开号：EP1960393A1

  公开（公告）日：2008-08-27
• LXR AND FXR MODULATORS
  申请人：Exelixis, Inc.

  公开号：EP2121621A1

  公开（公告）日：2009-11-25
• DETECTING PAX2 FOR THE DIAGNOSIS OF BREAST CANCER
  申请人：Phigenix, Inc.

  公开号：EP2475779A1

  公开（公告）日：2012-07-18