2-(碘甲基)苯酚 | 688753-87-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(碘甲基)苯酚
• 英文名称: 2-hydroxybenzyl iodide
• 英文别名: 2-(Iodomethyl)phenol
• CAS: 688753-87-9
• 化学式: C₇H₇IO
• 分子量: 234.036
• InChiKey: LJDPWFALMSMBLY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  9
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  水杨醇 在 Amberlyst 15 、 sodium iodide 作用下， 以 乙腈 为溶剂， 反应 0.83h， 以95%的产率得到2-(碘甲基)苯酚
  参考文献：
  名称：

  NaI/Amberlyst 15 在乙腈中选择性碘化醇

  摘要：

  使用 NaI/Amberlyst 15 在乙腈中在室温下将伯醇、仲醇、烯丙醇和苄醇转化为相应的碘化物的简单而有效的程序被描述。在这些条件下，可以在饱和醇存在下将苄醇选择性转化为相应的苄基碘。

  DOI：

  10.1055/s-2004-815445

文献信息

• Selective Iodination of Alcohols with NaI/Amberlyst 15 in Acetonitrile
  作者：Mahmood Tajbakhsh、Rahman Hosseinzadeh、Zahra Lasemi

  DOI：10.1055/s-2004-815445

  日期：——

  A simple and effective procedure for conversion of primary, secondary, allylic and benzylic alcohols into the corresponding iodides is described using NaI/Amberlyst 15 in acetonitrile at room temperature. Selective conversion of benzylic alcohols in the presence of saturated alcohols into the corresponding benzylic iodides is achieved under these conditions.

  使用 NaI/Amberlyst 15 在乙腈中在室温下将伯醇、仲醇、烯丙醇和苄醇转化为相应的碘化物的简单而有效的程序被描述。在这些条件下，可以在饱和醇存在下将苄醇选择性转化为相应的苄基碘。
• [EN] OCTAHYDROCYCLOPENTAPYRROLES, THEIR PREPARATION AND USE<br/>[FR] OCTAHYDROCYCLOPENTAPYRROLES, LEUR PRÉPARATION ET LEUR UTILISATION
  申请人：UNIV COLUMBIA

  公开号：WO2014152018A1

  公开（公告）日：2014-09-25

  The present invention provides Octahydrocyclopentapyrrole compounds having the structure: (structurally represented) wherein psi is absent or present, and when present is a bond; R1, R2, R3, R4, and R5 are each independently H, halogen, CF, or C1-C4 alkyl; R6 is absent or present, and when present is H, OH, or halogen; A is absent or present, and when present is C(O) or C(O)NH; B is substituted or unsubstituted monocycle, bicycle, heteromonocycle, heterobicycle, benzyl, CO2H or (C1-C4 alkyl)-CO2H, wherein when B is CO2H, then A is present and is C(O); and when psi is present, then R6 is absent and when psi is absent, then R6 is present, or a pharmaceutically acceptable salt thereof, for treatement of diseases characterized by excessive lipofuscin accumulation in the retina.

  本发明提供了具有以下结构的八氢环戊吡咯化合物：(结构表示) 其中psi为不存在或存在，当存在时为键；R1、R2、R3、R4和R5各自独立为H、卤素、CF或C1-C4烷基；R6不存在或存在，当存在时为H、OH或卤素；A不存在或存在，当存在时为C(O)或C(O)NH；B为取代或未取代的单环、双环、杂单环、杂双环、苄基、CO2H或(C1-C4烷基)-CO2H，其中当B为CO2H时，A存在且为C(O)；且当psi存在时，R6不存在，当psi不存在时，R6存在，或其药用可接受盐，用于治疗以视网膜过度脂褐素积聚为特征的疾病。
• Solvent‐Free Conversion of Alcohols into Iodides with NaI Supported on KSF Clay
  作者：Mahmood Tajbakhsh、Rahman Hosseinzadeh、Zahra Lasemi、Ali Rostami

  DOI：10.1080/00397910500297347

  日期：2005.11

  Abstract A variety of allylic, benzylic, primary, and secondary saturated alcohols have been converted into the corresponding iodides using NaI supported on KSF clay. Selective conversion of allylic and benzylic alcohols in the presence of primary and secondary saturated alcohols has also been demonstrated.

  摘要 使用负载在 KSF 粘土上的 NaI 已将各种烯丙基、苄基、伯和仲饱和醇转化为相应的碘化物。在伯和仲饱和醇存在下烯丙醇和苄醇的选择性转化也已得到证实。
• Ionic liquid-induced conversion of methoxymethyl-protected alcohols into nitriles and iodides using [Hmim][NO3]
  作者：Jalil Noei、Arsalan Mirjafari

  DOI：10.1016/j.tetlet.2014.06.016

  日期：2014.8

  This Letter reports a one-pot efficient conversion of methoxymethyl-ethers into their corresponding nitriles and iodides using the ionic liquid, 1-methyl-3H-imidazolium nitrate ([Hmim][NO3]) under microwave irradiation. A variety of products were prepared in high yields using this method.

  这封信报道了在微波辐射下，使用离子液体1-甲基-3 H-咪唑鎓硝酸盐（[Hmim] [NO 3 ]）一锅有效地将甲氧基甲基醚转化为其相应的腈和碘化物。使用这种方法可以高收率制备各种产品。
• Iodination of Alcohols Under Microwave Irradiation Using KI in the Presence of a Catalytic Amount of Ionic Liquid Triethylamoniom Hydrogensulfate
  作者：Abdol R. Hajipour、Ghobad Azizi、Arnold E. Ruoho

  DOI：10.1080/00397910802120916

  日期：2008.12.31

  The iodination of alcohols with KI in the presence of a catalytic amount of triethylamoniom hydrogensulfate ([image omitted]) as a novel and inexpensive ionic liquid under microwave irradiation has been investigated.