7-bromo-9,9-di-n-decyl-9H-fluorene-2-carboxaldehyde | 685531-16-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 芴
• 英文名称: 7-bromo-9,9-di-n-decyl-9H-fluorene-2-carboxaldehyde
• 英文别名: 7-bromo-9,9-didecyl-9H-fluorene-2-carbaldehyde；7-Bromo-9,9-didecylfluorene-2-carbaldehyde；7-dibromo-9,9-didecylfluorene-2-carbaldehyde
• CAS: 685531-16-2
• 化学式: C₃₄H₄₉BrO
• 分子量: 553.666
• InChiKey: REMZBEUHIAXCPP-UHFFFAOYSA-N

物化性质

• 沸点：
  617.2±48.0 °C(Predicted)
• 密度：
  1.077±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  14.3
• 重原子数：
  36
• 可旋转键数：
  19
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  17.1
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  7-bromo-9,9-di-n-decyl-9H-fluorene-2-carboxaldehyde 、 二硫代乙酰胺 以 异丁酰胺 、 xylene 为溶剂， 反应 6.0h， 以45%的产率得到2,5-Bis(7-bromo-9,9-didecylfluoren-2-yl)-1,3-thiazolo(5,4-d)1,3-thiazole
  参考文献：
  名称：

  Two-photon responsive chromophores containing electron accepting core units

  摘要：

  提供的是具有以下公式Q—(—L—Z)x的色素，其中x为2或3，其中Q是从组中选择的其中L是其中R是具有1到20个碳原子的烷基基团，其中Z是从组中选择的

  公开号：

  US06730793B1
• 作为产物：
  描述：

  2,7-二溴芴 在 正丁基锂 、 potassium tert-butylate 作用下， 以 四氢呋喃 、 正己烷 为溶剂， 反应 6.0h， 生成 7-bromo-9,9-di-n-decyl-9H-fluorene-2-carboxaldehyde
  参考文献：
  名称：

  PIPERAZINE-CONTAINING TWO-PHOTON ABSORBING COMPOUNDS

  摘要：

  提供了一种双光子吸收（TPA）化合物以及制备方法。该TPA化合物具有一般结构式：其中R1和R2分别选自由一般式CnH2n+1的线性或支链烷基链组成的群，n范围约为6到20，以及具有一般式R3（OCH2CH2）mOCH2CH2—的乙氧基化烷基，其中R3是C1到C4烷基基团，m范围约为0到3；Y选自H、OH和烷氧基团组成的群。

  公开号：

  US20180273524A1

文献信息

• Piperazine-containing two-photon absorbing compounds
  申请人：The United States of America, as represented by the Secretary of the Air Force

  公开号：US10336745B2

  公开（公告）日：2019-07-02

  A two-photon absorbing (TPA) compound is provided along with a method of making same. The TPA compound has a general structural formula: where R1 and R2 are independently selected from the group consisting of linear or branched alkyl chains having a general formula CnH2n+1, n ranges from about 6 to about 20, and ethoxylated alkyls having a general formula R3(OCH2CH2)mOCH2CH2—, where R3 is a C1 to C4 alkyl group, and where m ranges from 0 to about 3; and where Y is selected from the group consisting of H, OH, and alkoxyl groups.

  提供了一种双光子吸收（TPA）化合物及其制造方法。双光子吸收（TPA）化合物的结构通式如下 其中 R1 和 R2 独立地选自由通式为 CnH2n+1 的直链或支链烷基（n 范围从约 6 到约 20）和通式为 R3(OCH2CH2)mOCH2CH2-（其中 R3 为 C1 到 C4 烷基）的乙氧基化烷基（m 范围从 0 到约 3）组成的组；Y 选自由 H、OH 和烷氧基组成的组。
• Donor−Acceptor−Donor Fluorene Derivatives for Two-Photon Fluorescence Lysosomal Imaging
  作者：Sheng Yao、Hyo-Yang Ahn、Xuhua Wang、Jie Fu、Eric W. Van Stryland、David J. Hagan、Kevin D. Belfield

  DOI：10.1021/jo100554j

  日期：2010.6.18

  As part of a strategy to achieve large two-photon absorptivity in fluorene-based probes, a series of donor- acceptor-donor (D-A-D) type derivatives were synthesized and their two-photon absorption (2PA) properties investigated. The synthesis of D-A-D fluorophores was achieved by efficient preparation of key intermediates for the introduction of central electron acceptor groups. To accomplish the synthesis of two of the new derivatives, a high-yield method for a one-step direct dibromomethylation of phenyl sulfide was developed. The linear and nonlinear optical properties, including UV-vis absorption, fluorescence emission, fluorescence anisotropy, and two-photon absorption (2PA), of the new D-A-D compounds were measured and compared to their D-A or D-D counterparts. Fully conjugated acceptor moieties in the center of the D-A-D fluorophore led to the greatest increase in the 2PA cross section, while weakly conjugated central acceptors exhibited only a modest increase in the 2PA cross section relative to D-A diploar analogs. Encapsulation of the new probes in Pluronic F 108N F micelles, and subsequent incubation in HCT 116 cells, resulted in very high lysosomal colocalization (> 0.98 colocalization coefficient) relative to commercial Lysotracker Red, making the micelle-encapsulated dyes particularly attractive as fluorescent probes for two-photon fluorescence microscopy lysosomal imaging.
• US6730793B1
  申请人：——

  公开号：US6730793B1

  公开（公告）日：2004-05-04
• PIPERAZINE-CONTAINING TWO-PHOTON ABSORBING COMPOUNDS
  申请人：Government of the United States, as represented by the Secretary of the Air Force

  公开号：US20180273524A1

  公开（公告）日：2018-09-27

  A two-photon absorbing (TPA) compound is provided along with a method of making same. The TPA compound has a general structural formula: where R 1 and R 2 are independently selected from the group consisting of linear or branched alkyl chains having a general formula C n H 2n+1 , n ranges from about 6 to about 20, and ethoxylated alkyls having a general formula R 3 (OCH 2 CH 2 ) m OCH 2 CH 2 —, where R 3 is a C1 to C4 alkyl group, and where m ranges from 0 to about 3; and where Y is selected from the group consisting of H, OH, and alkoxyl groups.

  提供了一种双光子吸收（TPA）化合物以及制备方法。该TPA化合物具有一般结构式：其中R1和R2分别选自由一般式CnH2n+1的线性或支链烷基链组成的群，n范围约为6到20，以及具有一般式R3（OCH2CH2）mOCH2CH2—的乙氧基化烷基，其中R3是C1到C4烷基基团，m范围约为0到3；Y选自H、OH和烷氧基团组成的群。
• Two-photon responsive chromophores containing electron accepting core units
  申请人：The United States of America as represented by the Secretary of the Air Force

  公开号：US06730793B1

  公开（公告）日：2004-05-04

  Provided are chromophores of the formula Q—(—L—Z)x, wherein x is 2 or 3, wherein Q is selected from the group consisting of wherein L is wherein R is an alkyl group having 1 to 20 carbon atoms, and wherein Z is selected from the group consisting of

  提供的是具有以下公式Q—(—L—Z)x的色素，其中x为2或3，其中Q是从组中选择的其中L是其中R是具有1到20个碳原子的烷基基团，其中Z是从组中选择的