2-(苯基)-3-(N,N-二甲氨基)-1-丙烯 | 35513-04-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-(苯基)-3-(N,N-二甲氨基)-1-丙烯
• 英文名称: 2-(phenyl)-3-(N,N-dimethylamino)-1-propene
• 英文别名: 3-N,N-dimethylamino-2-phenyl-1-propene；3-Dimethylamino-2-phenyl-propen；N,N-dimethyl-2-phenylprop-2-en-1-amine
• CAS: 35513-04-3
• 化学式: C₁₁H₁₅N
• 分子量: 161.247
• InChiKey: VUFUFVPTWMFETD-UHFFFAOYSA-N

物化性质

• 沸点：
  55-60 °C(Press: 0.4 Torr)
• 密度：
  0.918±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-(苯基)-3-(N,N-二甲氨基)-1-丙烯 在 氢气 作用下， 生成 N,N-dimethyl-2-phenylpropan-1-amine
  参考文献：
  名称：

  240.二甲氨基自由基·NMe 2的一些反应

  摘要：

  DOI：

  10.1039/jr9610001228
• 作为产物：
  描述：

  alpha-氯乙酰苯 在 二甲胺 、 三乙胺 作用下， 生成 2-(苯基)-3-(N,N-二甲氨基)-1-丙烯
  参考文献：
  名称：

  AMINE-FUNCTIONAL MONOMERS AND METHODS OF MAKING SAME

  摘要：

  Disclosed herein are addition-polymerizable monomer composition including an amine-derivatized alpha-methyl styrene (ADAMS) monomer according to structure (I) and/or an aminated conjugated aliphatic methylated polyene (ACAMP) monomer according to structure (II): with k, R 1 , R 2 , R 3 , and R 4 defined herein. Difunctional monomers of these types with two polymerizable loci and/or two amine loci are also disclosed herein. Further disclosed herein are methods for making such compositions.

  公开号：

  US20240287009A1

文献信息

• ENGINEERED CELLS AND AGENT COMPOSITIONS FOR THERAPEUTIC AGENT DELIVERY AND TREATMENTS USING SAME
  申请人：UNIVERSITY OF WASHINGTON

  公开号：US20200276318A1

  公开（公告）日：2020-09-03

  Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

  本文提供了经过工程改造的细胞以及用于工程改造细胞以传递治疗剂的方法，例如小分子、肽或其他药物，以传递到待治疗的细胞或组织。
• CELL BASED METHODS AND COMPOSITIONS FOR THERAPEUTIC AGENT DELIVERY AND TREATMENTS USING SAME
  申请人：UNIVERSITY OF WASHINGTON

  公开号：US20200405881A1

  公开（公告）日：2020-12-31

  Provided herein are engineered cells and methods for engineering cells to deliver a therapeutic agent, e.g., a small molecule, peptide or other drug, to a cell or tissue to be treated.

  本文提供了经过工程改造的细胞以及用于工程改造细胞以传递治疗剂的方法，例如小分子、肽或其他药物，以治疗细胞或组织。
• METHOD FOR PRODUCING MODIFIED CONJUGATED DIENE-BASED POLYMER, MODIFIED CONJUGATED DIENE-BASED POLYMER, POLYMER COMPOSITION, CROSSLINKED BODY, TIRE AND COMPOUND
  申请人：JSR CORPORATION

  公开号：US20190194430A1

  公开（公告）日：2019-06-27

  A modified conjugated diene-based polymer having high Mooney viscosity and good shape stability and exhibiting excellent processability and low heat build-up is obtained in as few steps as possible. The modified conjugated diene-based polymer is produced by a method of reacting a conjugated diene-based polymer having an active chain end, obtained by polymerizing a monomer containing a conjugated diene compound in the presence of an initiator that contains at least either of an alkali metal compound and an alkaline earth metal compound, with a compound [M] having at least two groups selected from the group consisting of a group “—C(R 1 )N-A 1 ” and a group “—N═C(R 1 )-A 1 ”, where R 1 is a hydrogen atom or a hydrocarbyl group and A 1 is a monovalent group having an alkoxysilyl group.

  通过尽可能少的步骤获得具有高莫尼粘度和良好形状稳定性、表现出优异加工性和低热积聚的改性共轭二烯基聚合物。这种改性共轭二烯基聚合物是通过一种方法制备的，该方法涉及将在至少含有碱金属化合物和碱土金属化合物中的至少一种的引发剂存在下聚合含有共轭二烯化合物的单体而获得具有活性链端的共轭二烯基聚合物与具有至少两个从群组“—C(R1)N-A1”和群组“—N═C(R1)-A1”中选择的基团的化合物[M]反应，其中R1是氢原子或烃基团，A1是具有烷氧基团的一价基团。
• Polymeric boronic acid derivatives as lipase inhibitors
  申请人：Huval Cori Chad

  公开号：US20060134062A1

  公开（公告）日：2006-06-22

  Human obesity is a health problem affecting a significant proportion of the American population. Numerous methods of treating obesity have been developed, but all have serious drawbacks. The present invention discloses a novel class of polymers with either a sulfur atom or an electron withdrawing group between a polymer backbone and a pendant aryl boronic acid group. Polymers having such an electron withdrawing group have been found to be particularly effective in inhibiting lipase in vitro and in vivo. Methods of treating obesity and reducing absorption of fat are also disclosed.

  人类肥胖是影响美国人口相当大比例的健康问题。已经开发了许多治疗肥胖的方法，但都存在严重缺陷。本发明揭示了一种新型聚合物类别，其在聚合物主链和挂链芳基硼酸基团之间具有硫原子或电子吸引基团。发现具有这种电子吸引基团的聚合物在体外和体内抑制脂肪酶特别有效。还公开了治疗肥胖和减少脂肪吸收��方法。
• [EN] RADIANT STAR NANOPARTICLE PRODRUGS AND RELATED METHODS<br/>[FR] PROMÉDICAMENTS À NANOPARTICULES EN ÉTOILE ET MÉTHODES ASSOCIÉES
  申请人：UNIV WASHINGTON

  公开号：WO2019160983A1

  公开（公告）日：2019-08-22

  Radiant star nanoparticle prodrugs, methods for making the nanoparticle prodrugs, and methods for using the nanoparticle prodrugs for the delivery of therapeutic agents.

  辐射星纳米颗粒前药，制备纳米颗粒前药的方法，以及利用纳米颗粒前药传递治疗药物的方法。