1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ester 2-(N-1-piperazinyl)ethyl ester | 99522-55-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ester 2-(N-1-piperazinyl)ethyl ester
• 英文别名: methyl 2-piperazinylethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate；3-O-methyl 5-O-(2-piperazin-1-ylethyl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
• CAS: 99522-55-1
• 化学式: C₂₂H₂₈N₄O₆
• 分子量: 444.488
• InChiKey: VAZFRIZKMWKKBS-UHFFFAOYSA-N

物化性质

• 沸点：
  605.8±55.0 °C(Predicted)
• 密度：
  1.240±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  32
• 可旋转键数：
  8
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.45
• 拓扑面积：
  126
• 氢给体数：
  2
• 氢受体数：
  9

反应信息

• 作为反应物：
  描述：

  1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ester 2-(N-1-piperazinyl)ethyl ester 、 双苯甲醇-β-氯乙基醚 在 sodium hydroxide 、 盐酸 作用下， 以 甲苯 、 乙醚 为溶剂， 反应 2.0h， 以31.9%的产率得到1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ester 2-(N-4-(diphenylmethoxyethyl)piperazinyl)ethyl ester hydrochloride
  参考文献：
  名称：

  DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS AND MEDICAL USES THEREOF

  摘要：

  公开号：

  EP2251337B1
• 作为产物：
  描述：

  哌嗪 、 2-氯乙基甲基 1,4-二氢-2,6-二甲基-4-(3-硝基苯基)吡啶-3,5-二羧酸酯 以 乙腈 为溶剂， 反应 3.0h， 以65%的产率得到1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinecarboxylic acid methyl ester 2-(N-1-piperazinyl)ethyl ester
  参考文献：
  名称：

  DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS AND MEDICAL USES THEREOF

  摘要：

  公开号：

  EP2251337B1

文献信息

• Novel dihydropyridine derivatives
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US05034395A1

  公开（公告）日：1991-07-23

  Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phophodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.

  二氢吡啶衍生物及其盐，由一般式##STR1##表示，具有优异的钙拮抗剂作用、降压作用、血小板聚集抑制作用、磷酸二酯酶抑制作用、钙调蛋白抑制作用和过氧化脂质降低作用。因此，二氢吡啶衍生物及其盐可用作冠状动脉血流改善剂，如冠状动脉扩张剂、降压剂、预防和治疗血栓的药物、磷酸二酯酶抑制剂、过氧化脂质代谢降低剂、抗炎剂等。
• Dihydropyridine derivatives and process for preparing the same
  申请人：Otsuka Pharmaceutical Co., Ltd.

  公开号：US05137889A1

  公开（公告）日：1992-08-11

  Dihydropyridine derivatives and salts thereof represented by the general formula, ##STR1## which possess excellent calcium antagonist effect, hypotensive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phosphodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.

  通式为##STR1##的二氢吡啶衍生物及其盐具有出色的钙拮抗作用、降压作用、抑制血小板聚集作用、磷酸二酯酶抑制作用、钙调蛋白抑制作用和过氧化脂质降低作用，因此二氢吡啶衍生物及其盐可用作冠状动脉血流改善剂，如冠状动脉扩张剂、降压剂、预防和治疗血栓的药物、磷酸二酯酶抑制剂、过氧化脂质代谢降低剂、抗炎剂等。
• Novel dihydropyridine derivatives and process for preparing the same
  申请人：OTSUKA PHARMACEUTICAL CO., LTD.

  公开号：EP0145434A2

  公开（公告）日：1985-06-19

  Dihydropyridine derivatives and salts thereof represented by the general formula, which possess excellent calcium antagonist effect, hypoten- sive effect, platelets aggregation inhibitory effect, phosphodiesterase inhibitory effect, calmodulin inhibitory effect and peroxidized lipid lowering effect, and thus dihydropyridine derivatives and salts thereof are useful as a coronary blood flow improving agent such as coronary vasodilator, hypotensive agent, prophylaxis and treating agents for thrombosis, phosphodiesterase inhibitory agent, peroxidized lipid metabolism lowering agent, anti-inflammatory agent and others.

  通式代表的二氢吡啶衍生物及其盐、 具有良好的钙拮抗剂作用、降血压作用、血小板聚集抑制作用、磷酸二酯酶抑制作用、钙调素抑制作用和过氧化脂质降低作用、因此，二氢吡啶衍生物及其盐类可用作冠状动脉血流改善剂，如冠状动脉血管扩张剂、降血压剂、血栓预防和治疗剂、磷酸二酯酶抑制剂、过氧化脂质代谢降低剂、消炎剂等。
• DIHYDROPYRIDINE CALCIUM ANTAGONIST COMPOUNDS, PREPARATION METHODS, AND MEDICAL USES THEREOF
  申请人：Chen Guo-hua

  公开号：US20110201811A1

  公开（公告）日：2011-08-18

  A dihydropyridine (DHP) calcium antagonist compound and its preparation method and medical use are related to preparation methods of compounds of general formulas (I) and (II) as shown below and their pharmaceutical salts and applications for treating cardiovascular diseases, and R 1 represents a substituted or unsubstituted heterocyclic, aromatic ring or aralkyl group, and the substituent may be C 1 -C 4 alkyl, C 1 -C 4 alkoxyl, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro, amino or hydroxyl group; R 2 represents a C 1 -C 8 alkyl group; R 3 and R 4 are the same or different, and each represents a hydrogen, halogen, cyano, trifluoromethyl, trifluoromethoxyl, methylthio, nitro or amino group or a C 1 -C 4 alkyl, C 1 -C 4 alkoxyl, C 1 -C 4 alkenyl, or C 1 -C 4 alkinyl group; R 5 and R 6 are the same or different, and each represents a C 1 -C 4 alkyl group; X represents O, S or a single bond; m=0-6, n=1-6, and m and n are the same or different.
• US5034395A
  申请人：——

  公开号：US5034395A

  公开（公告）日：1991-07-23