3'-isopropylbiphenyl-3-ol | 1279015-88-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3'-isopropylbiphenyl-3-ol
• 英文别名: 3-(3-Propan-2-ylphenyl)phenol
• CAS: 1279015-88-1
• 化学式: C₁₅H₁₆O
• 分子量: 212.291
• InChiKey: UEJVRDZEVUVEDB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3'-isopropylbiphenyl-3-ol 、 toluene-4-sulfonic acid (S)-5-(1,1-difluoro-propyl)-7-oxo-2,3-dihydro-7H-oxazolo[3,2-a]pyrimidin-2-ylmethyl ester 在 caesium carbonate 作用下， 以 乙腈 为溶剂， 以53%的产率得到(S)-5-(1,1-difluoropropyl)-2-(3'-isopropylbiphenyl-3-yloxymethyl)-2,3-dihydro-oxazolo[3,2-a]pyrimidin-7-one
  参考文献：
  名称：

  [EN] SUBSTITUTED PARA-BIPHENYLOXYMETHYL DIHYDRO OXAZOLOPYRIMIDINONES, PREPARATION AND USE THEREOF
  [FR] PARA-BIPHÉNYLOXYMÉTHYL-DIHYDRO-OXAZOLOPYRIMIDINONES SUBSTITUÉES, LEUR PRÉPARATION ET LEUR UTILISATION

  摘要：

  本发明涉及一系列以本文所定义的式(I)的取代对联苯氧甲基二氢噁唑吡咯嘧啶酮。本发明还涉及制备这些化合物的方法，包括新颖的中间体。本发明的化合物是代谢型谷氨酸受体（mGluR），特别是mGluR2受体的调节剂。因此，本发明的化合物在药物代理方面是有用的，特别是在治疗和/或预防各种中枢神经系统疾病（CNS），包括但不限于急性和慢性神经退行性疾病、精神病、认知缺陷症、癫痫、焦虑、抑郁、偏头痛、疼痛、睡眠障碍和呕吐等方面。

  公开号：

  WO2011034828A1

文献信息

• SUBSTITUTED BIARYL COMPOUNDS AS FACTOR XIA INHIBITORS
  申请人：Corte James R.

  公开号：US20090062287A1

  公开（公告）日：2009-03-05

  The present invention provides compounds of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt or solvate form thereof, wherein the variables A, L, Z, R 3 , and ring B are as defined herein. The compounds of Formula (I) are useful as selective inhibitors of serine protease enzymes of the coagulation cascade and/or contact activation system; for example thrombin, factor Xa, factor XIa, factor IXa, factor VIIa and/or plasma kallikrein. In particular, it relates to compounds that are selective factor XIa inhibitors. This invention also relates to pharmaceutical compositions comprising these compounds and methods of treating thromboembolic and/or inflammatory disorders using the same.

  本发明提供了式（I）的化合物：或其立体异构体，互变异构体，药学上可接受的盐或溶剂形式，其中变量A、L、Z、R3和环B的定义如本文所述。式（I）的化合物可作为凝血级联反应和/或接触激活系统的丝氨酸蛋白酶酶的选择性抑制剂，例如凝血酶、因子Xa、因子XIa、因子IXa、因子VIIa和/或血浆激肽。特别地，本发明涉及选择性因子XIa抑制剂的化合物。本发明还涉及包含这些化合物的制药组合物和使用它们治疗血栓栓塞性和/或炎症性疾病的方法。
• Resin composition, method of its composition, and cured formulation
  申请人：NIPPON SHOKUBAI CO., LTD.

  公开号：EP1626065A1

  公开（公告）日：2006-02-15

  It is an object of the present invention to provide a resin composition which can form cured formulations having various excellent properties such as an insulating property, thermal shock resistance, moldability/formability and strength, and exhibit an excellent appearance inwhich transparency is enhanced, a resin composition whose cured thin film has excellent flame retardancy, good mechanical property and heat resistance, a dispersing element containing an inorganic microfine particle which can give a flame retardancy to a resin, to which the inorganic microfine particle is added, and can reduce a hygroscopic property to the extent possible, a method for producing the same and a cured formulation obtained by using the resin composition. The present invention relates to a resin composition comprising a compound having at least one of a glycidyl group and/or an epoxy group and an inorganic microfine particle, a resin composition comprising three components of a phenolic compound, a compound having at least one of a glycidyl group and/or an epoxy group and an inorganic microfine particle, a flame retardant resin composition comprising a polyhydric phenol and an inorganic microfine particle, and a dispersing element containing an inorganic microfine particle obtained by a hydrolysis condensation reaction of alkoxide and/or metal carboxylate in a dispersion medium.

  本发明的目的是提供一种树脂组合物，该树脂组合物可形成具有各种优异性能（如绝缘性、抗热震性、成型性/可成形性和强度）的固化配方，并表现出优异的外观（其中透明度得到提高）；一种树脂组合物，该树脂组合物的固化薄膜具有优异的阻燃性、本发明涉及一种树脂组合物，其固化薄膜具有优异的阻燃性、良好的机械性能和耐热性；一种含有无机微细颗粒的分散元素，该分散元素可使添加了无机微细颗粒的树脂具有阻燃性，并可尽可能降低吸湿性；一种生产方法；以及一种通过使用该树脂组合物获得的固化配方。本发明涉及一种树脂组合物，该树脂组合物由至少一个具有缩水甘油基和/或环氧基的化合物和无机微细颗粒组成；一种树脂组合物，该树脂组合物由酚类化合物、至少一个具有缩水甘油基和/或环氧基的化合物和无机微细颗粒三部分组成、一种阻燃树脂组合物，包括一种多羟基酚和一种无机微细颗粒，以及一种含有无机微细颗粒的分散元件，该无机微细颗粒是通过烷氧基和/或金属羧酸盐在分散介质中的水解缩合反应获得的。
• Resin Composition for Optical Packaging Material and Process for Preparing the Same, and Optical Packaging Material, Optical Packaging Component, and Optical Module
  申请人：Sugioka Takuo

  公开号：US20090010603A1

  公开（公告）日：2009-01-08

  To provide to a resin composition for an optical packaging material having a coefficient of thermal expansion approximately same as that of quartz and Pyrex (registered trade name) and capable of providing an optical packaging material exhibiting excellent flame retardancy and an optical packaging component, and an optical module and its production method. A molded body, an optical packaging component and an optical module having a low coefficient of thermal expansion and excellent flame retardancy can be obtained using a resin composition for an optical packaging material comprising a resin and inorganic fine particles which are made of a hydrolyzed condensate compound of an alkoxide compound and/or a carboxylic acid salt compound and have an average radius of gyration of 50 nm or smaller.
• SILANE COMPOUND, PRODUCTION METHOD THEREOF, AND RESIN COMPOSITION CONTAINING SILANE COMPOUND
  申请人：Sugioka Takuo

  公开号：US20100317774A1

  公开（公告）日：2010-12-16

  The present invention provides a silane compound which can be preferably used in an electronics application and the like, as a resin composition which is excellent in heat resistance, pressure resistance, water resistance, low moisture absorption property, low dielectric property, mechanical and chemical stability, and heat conductivity and capable of forming cured articles which hardly reduce physical properties even under severe environments such as high temperature and high pressure and high humidity; its production method, and a resin composition containing the silane compound. The silane compound of the present invention provides a silane compound having a siloxane bond and an imido bond, wherein the silane compound comprises a structure unit formed by connecting at least one organic skeleton having an imido bond to a silicon atom forming a siloxane bond, wherein the silane compound is defined by the following average composition formula: XaYbZcSiOd in the formula, X may be same or different and denotes a group including an organic skeleton having an imido bond, represented by the following formula (1); Z may be same or different and denotes an organic group having no imido bond; Y may be same or different and denotes at least one selected from the group consisting of hydrogen atom, hydroxyl group, halogen atom, and OR group; R may be same or different and denotes at least one selected from the group consisting of alkyl, acyl, aryl, and unsaturated aliphatic residual groups and may have a substituent; a is a numeral of 3 or lower but not 0; b is 0 or a numeral less than 3; c is 0 or a numeral less than 3; d is a numeral less than 2 but not 0; and a+b+c+2d=4, in the formula, R 1 denotes at least one structure selected from the group consisting of aromatic, heterocyclic, and alicyclic rings; x and z may be same or different and independently denote an integer of 0 or higher and 5 or lower; and y is 0 or 1.
• US7459564B2
  申请人：——

  公开号：US7459564B2

  公开（公告）日：2008-12-02