1-hydroxy-4-(2'-methoxyethoxy)-pyrid-2-one | 99110-88-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-hydroxy-4-(2'-methoxyethoxy)-pyrid-2-one
• 英文别名: 1-hydroxy-4-(2-methoxyethoxy)pyridin-2-one
• CAS: 99110-88-0
• 化学式: C₈H₁₁NO₄
• 分子量: 185.18
• InChiKey: XWMSVMYDTRHCTQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  59
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-氯-4-硝基吡啶 N-氧化物 生成 1-hydroxy-4-(2'-methoxyethoxy)-pyrid-2-one
  参考文献：
  名称：

  HIDER, R. C.;KONTOGHIORGHES, G.;SILVER, J.;STOCKHAM, M. A.

  摘要：

  DOI：

文献信息

• Pharmaceutical compositions
  申请人：National Research Development Corp.

  公开号：US04587240A1

  公开（公告）日：1986-05-06

  Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, aliphatic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substituted by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected only by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof containing a physiolgically acceptable ion or ions, are of value in the treatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.

  具有1-羟基吡啶-2-酮结构的化合物，其中环碳原子上的氢原子被从脂肪酰基，脂肪酰胺，脂肪胺，羧基，氰基，脂肪酯，卤素，羟基和磺酸基，烷氧基以及被烷氧基，脂肪酰胺，脂肪胺，脂肪酯，卤素或羟基取代的烷氧基取代的取代基所取代，脂肪烃基以及被烷氧基，脂肪酯，卤素或羟基取代的脂肪烃基，但不包括仅通过脂肪烃基，卤素基和被卤素基取代的脂肪烃基所取代的化合物，或者其含有生理上可接受的离子的盐，对于治疗体内有毒浓度的金属，尤其是铁，尤其有价值，而这些化合物的铁络合物对于治疗缺铁性贫血也具有价值。
• Calibrachoa plant named ‘Docaltitor50’
  申请人：DUMMEN GROUP B.V.

  公开号：USPP034313P2

  公开（公告）日：2022-06-07

  A new and distinct cultivar of Calibrachoa plant named ‘Docaltitor50’, characterized by its outwardly spreading, trailing and decumbent plant habit; vigorous growth habit; freely branching habit; early and freely flowering habit; large flowers with purplish red-colored petals with dark red-colored centers and venation and vivid yellow-colored throats and central star; and good garden performance.

  一种新的、独特的Calibrachoa植物品种，名为“Docaltitor50”，其特征为向外扩展、蔓延和倾斜的植株习性；生长旺盛；分枝自由；早期和自由开花习性；大花，紫红色花瓣，中心和脉红色，鲜黄色喉部和中央星形；以及良好的园艺表现。
• Pharmaceutical compositions containing 1-hydroxypyrid-2-one derivatives
  申请人：NATIONAL RESEARCH DEVELOPMENT CORPORATION

  公开号：EP0138420A2

  公开（公告）日：1985-04-24

  Compounds which are a 1-hydroxypyrid-2-one in which one or more of the hydrogen atoms attached to ring carbon atoms are eplaced by a substituent selected from aliphatic acyl, aliphatic amide, aliphatic amine, carboxy, cyano, aliphatic ester, halogen, hydroxy and sulpho groups, alkoxy groups and alkoxy groups substituted by an alkoxy, aliphatic amide, aliphatic amine, alipha- :ic ester, halogen or hydroxy group, aliphatic hydrocarbon groups and aliphatic hydrocarbon groups substitued by an alkoxy, aliphatic ester, halogen or hydroxy group, but excluding compounds in which said replacement of hydrogen atoms in the compound is effected onyl by substituents selected from aliphatic hydrocarbon groups, halogen groups and aliphatic hydrocarbon groups substituted by a halogen group, or a salt thereof contain- ng a physiolgically acceptable ion or ions, are of value in the :reatment of patients having a toxic concentration of a metal, particularly iron, in the body whilst the iron complexes of such compounds are of value in the treatment of iron deficiency anaemia.

  1- 羟基吡啶-2-酮的化合物，其中连接到环碳原子上的一个或多个氢原子被选自脂族酰基、脂族酰胺、脂族胺、羧基、氰基、脂族酯、卤素、羟基和磺基、烷氧基和被烷氧基取代的烷氧基、脂族酰胺、脂族胺、脂族酯、卤素或羟基、脂族烃基和被烷氧基、脂族酯、卤素或羟基取代的脂族烃基的取代基取代的化合物：烷氧基基团和被烷氧基、脂肪族酯、卤素或羟基取代的烷氧基基团和脂肪族烷氧基基团，但不包括通过选自脂 肪族烃基团、卤素基团和被卤素基团取代的脂肪族烃基团的取代基取代化合物中氢原子的化合物，或含有一种 或多种生理上可接受的离子的盐，在......治疗具有毒性的患者方面具有价值：此类化合物的铁络合物在治疗缺铁性贫血症方面具有价值。
• HIDER, R. C.;KONTOGHIORGHES, G.;SILVER, J.;STOCKHAM, M. A.
  作者：HIDER, R. C.、KONTOGHIORGHES, G.、SILVER, J.、STOCKHAM, M. A.

  DOI：——

  日期：——
• The stabilization of organic compounds
  申请人：BRITISH TECHNOLOGY GROUP LIMITED

  公开号：EP0397409B1

  公开（公告）日：1993-07-21