2-(2-methyl-2-butyl) benzoxazole | 108071-44-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并恶唑类
• 英文名称: 2-(2-methyl-2-butyl) benzoxazole
• 英文别名: 2-(tert-pentyl)benzo[d]oxazole；2-(2-methylbutan-2-yl)-1,3-benzoxazole
• CAS: 108071-44-9
• 化学式: C₁₂H₁₅NO
• 分子量: 189.257
• InChiKey: XURJJPYCKYQTBM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  14
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  26
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  2-巯基苯并恶唑 在 palladium on activated charcoal 二氯化二硫 、 氢气 作用下， 以 二氯甲烷 为溶剂， 反应 1.0h， 生成 2-(2-methyl-2-butyl) benzoxazole
  参考文献：
  名称：

  2-氯苯并恶唑与β，γ-不饱和格氏试剂的交叉偶联：区域选择性合成2-烯丙基-，2-烯基-和2-炔丙基-苯并恶唑

  摘要：

  β，γ-不饱和格氏试剂与2-氯苯并恶唑在区域上选择性反应，从而获得高至优异的2-烯丙基-，2-烯基-和2-炔丙基-苯并恶唑的收率。2-烯丙基苯并恶唑的还原导致支链2-烷基苯并恶唑的定量收率。

  DOI：

  10.1016/s0040-4020(01)87545-1

文献信息

• Silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids
  作者：Wei-Ming Zhao、Xiao-Lan Chen、Jin-Wei Yuan、Ling-Bo Qu、Li-Kun Duan、Yu-Fen Zhao

  DOI：10.1039/c3cc48069k

  日期：——

  A novel and efficient silver catalyzed decarboxylative direct C2-alkylation of benzothiazoles with carboxylic acids for the synthesis of 2-alkyl benzothiazoles was developed.

  开发了一种新颖且高效的银催化脱羧直接C2烷基化苯并噻唑与羧酸的反应，用于合成2-烷基苯并噻唑。
• PYRROLO [2,3-C] PYRIDINE DERIVATIVES AS P38 KINEASE INHIBITING AGENTS
  申请人：Sahoo Soumya P.

  公开号：US20110105430A1

  公开（公告）日：2011-05-05

  Compounds described by the chemical formula (I) or pharmaceutically acceptable salts thereof: (A) are inhibitors N of p38 and are useful in the treatment of inflammation such as in the treatment of asthma, rheumatoid arthritis, rheumatoid spondylitis, osteoarthritis, gouty arthritis and other arthritic conditions; inflamed joints, eczema, psoriasis or other inflammatory skin conditions such as sunburn; inflammatory eye conditions including conjunctivitis; pyresis, pain and other conditions associated with inflammation.

  化学式（I）描述的化合物或其药学上可接受的盐：（A）是p38的抑制剂，可用于治疗炎症，例如哮喘、类风湿性关节炎、类风湿性脊柱炎、骨关节炎、痛风性关节炎和其他关节炎症状；炎症关节、湿疹、牛皮癣或其他炎症性皮肤病，如晒伤；炎症性眼部疾病，包括结膜炎；与炎症相关的发热、疼痛和其他症状。
• HIGHLY EFFECTIVE PHOTOPROTECTIVE AGENTS
  申请人：3V SIGMA S.p.A

  公开号：EP3578558A1

  公开（公告）日：2019-12-11

  Disclosed are triazine compounds of formula (I): wherein R is as defined in the description, as light stabilisers and photoprotectors against UV-visible radiation.

  所公开的是式 (I) 的三嗪化合物： 其中 R 如说明中所定义，可作为光稳定剂和光保护剂，抵御紫外线和可见光辐射。
• BABUDRI F.; FLORIO S.; RONZINI L., TETRAHEDRON, 42,(1986) N 14, 3905-3911
  作者：BABUDRI F.、 FLORIO S.、 RONZINI L.

  DOI：——

  日期：——
• Process and apparatus for online detection of surface irregularity in threadlines
  申请人：Kaminer Jon Jacob

  公开号：US20080151261A1

  公开（公告）日：2008-06-26

  The invention concerns a process and apparatus for monitoring the level of surface irregularity in a moving threadline, comprising: (a) illuminating the threadline via a light source positioned incident to the thread line at an entrance angle of greater than 0 degrees and less than 90 degrees to the threadline to produce spectral reflectance energy and diffuse reflectance energy; (b) measuring the amount of spectral reflectance energy from the threadline with a first receiver positioned incident to the threadline at an exit angle that is substantially equal to the entrance angle; (c) measuring the amount of diffuse reflectance energy from the threadline with a second receiver positioned at an angle that is different than the entrance angle and the exit angle, (d) determining the ratio of the amount of diffuse reflectance energy to the amount of spectral reflectance energy; and (e) relating said ratio to the level of surface irregularity.