2,4-diaminobenzenethiol | 21715-13-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯硫酚类
• 英文名称: 2,4-diaminobenzenethiol
• 英文别名: 2,4-diamino-thiophenol；2,4-Diaminobenzene-1-thiol
• CAS: 21715-13-9
• 化学式: C₆H₈N₂S
• mdl: MFCD19204297
• 分子量: 140.209
• InChiKey: ORBBRCGLUKANIM-UHFFFAOYSA-N

物化性质

• 沸点：
  336.3±27.0 °C(Predicted)
• 密度：
  1.315±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.4
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  53
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  2,4-diaminobenzenethiol 生成 benzo[1,2,3]thiadiazol-5-ol
  参考文献：
  名称：

  195.在某些还原形式的2：2'：4：4'-四硝基二苯基一硫化物和二硫化物中消除硫，以及制备某些5-取代的苯并-1-硫-2：3的替代方法-二唑

  摘要：

  DOI：

  10.1039/jr9480001002
• 作为产物：
  描述：

  双(2,4-二硝基苯)二硫化碳 在 盐酸 、 tin(ll) chloride 作用下， 生成 2,4-diaminobenzenethiol
  参考文献：
  名称：

  New Schiff bases derived from 2,5-dihydroxybenzaldehyde and amino-substituted 2-phenyl-1,3-benzothiazoles. Mesogenic monomers for liquid crystalline polyethers

  摘要：

  DOI：

  10.1134/s1070428011100307

文献信息

• Design, synthesis and biological evaluation of benz‐fused five‐membered heterocyclic compounds as tubulin polymerization inhibitors with anticancer activities
  作者：Buduma Komuraiah、Yichang Ren、Mingming Xue、Binbin Cheng、Jin Liu、Yao Liu、Jianjun Chen

  DOI：10.1111/cbdd.13832

  日期：2021.5

  A series of benz‐fused five‐membered heterocyclic compounds were designed and synthesized as novel tubulin inhibitors targeting the colchicine binding site. Among them, compound 4d displayed the highest antiproliferative activity against four cancer cell lines with an IC50 value of 4.9 μM in B16‐F10 cells. Compound 4d effectively inhibited tubulin polymerization in vitro (IC50 of 13.1 μM). Further

  设计并合成了一系列苯并稠合五元杂环化合物作为靶向秋水仙碱结合位点的新型微管蛋白抑制剂。其中，化合物4d对四种癌细胞系显示出最高的抗增殖活性，在B16-F10细胞中的IC 50值为4.9 μM。化合物 4d 在体外有效抑制微管蛋白聚合（IC 50为 13.1 μM）。此外，4d 诱导细胞周期停滞在 G2/M 期。最后，4d 以剂量依赖性方式抑制癌细胞的迁移。总之，这些结果表明化合物 4d 代表了一类新的微管蛋白抑制剂，值得进一步研究。
• Siloxane-containing polymers
  申请人：M & T Chemicals Inc.

  公开号：US04395527A1

  公开（公告）日：1983-07-26

  The properties of polymeric compositions can be improved by the presence of a polysiloxane unit of formula ##STR1## where Q is a substituted or unsubstituted aromatic group, Z is ##STR2## D is unsubstituted or substituted hydrocarbylene R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 each, independently, is unsubstituted or substituted hydrocarbyl. x, y and z each independently has a value from 0 to 100. Polyimides containing these units display improved solubility and adhesion; they are useful, among other things as protective coatings.

  聚合物组分的性质可以通过具有式为##STR1##的聚硅氧烷单元的存在而得到改善，其中Q是取代或未取代的芳香基团，Z是##STR2##，D是未取代或取代的烃基R.sup.1，R.sup.2，R.sup.3，R.sup.4，R.sup.5和R.sup.6各自独立地是未取代或取代的烃基。x，y和z每个独立地具有0到100的值。含有这些单元的聚酰亚胺显示出改善的溶解性和粘附性；它们在许多方面都很有用，例如作为保护涂料。
• RESIN COMPOSITION AND SEMICONDUCTOR DEVICE BOARD
  申请人：Osaku Yumi

  公开号：US20140087136A1

  公开（公告）日：2014-03-27

  A resin composition which contains a binder resin (A), radiation-sensitive compound (B), silane-modified resin (C), and antioxidant (D), wherein a content of the silane-modified resin (C) is 0.1 to 150 parts by weight with respect to 100 parts by weight of the binder resin (A), a content of the antioxidant (D) is 0.1 to 10 parts by weight with respect to 100 parts by weight of the binder resin (A), and an amount of warping is 14 μm or less when using the resin composition to form a thickness 2 to 3 μm resin film and baking the formed resin film at 230° C. is provided.

  一种树脂组合物，包含粘合剂树脂（A），辐射敏感化合物（B），硅改性树脂（C）和抗氧化剂（D），其中硅改性树脂（C）的含量相对于100份粘合剂树脂（A）为0.1至150份重量，抗氧化剂（D）的含量相对于100份粘合剂树脂（A）为0.1至10份重量，并且使用该树脂组合物形成2至3μm厚度的树脂膜并在230°C下烘烤形成的树脂膜翘曲量为14μm或以下。
• Improvements in or relating to siloxanes
  申请人：M & T CHEMICALS, INC.

  公开号：EP0054426A2

  公开（公告）日：1982-06-23

  The properties of polymeric compositions can be improved by the presence of a polysiloxane unit of formula where Q is a substituted or unsubstituted aromatic group, D is unsubstituted or substituted hydrocarbylene R1, R2, R3, R4, R5 and R6 each, independently, is unsubstituted or substituted hydrocarbyl. x, y and z each independently has a value from 0 to 100. Polyimides containing these units display improved solubility and adhesion; they are useful, among other things, as protective coatings.

  聚合体组合物的性能可以通过存在式中的聚硅氧烷单元得到改善 式中 Q 是取代或未取代的芳香基团、 D为未取代或取代的烃基 R1、R2、R3、R4、R5 和 R6 各自独立地为未取代或取代的烃基。 x、y 和 z 各自独立地具有 0 至 100 之间的数值。 含有这些单元的聚酰亚胺具有更好的溶解性和粘附性，可用作保护涂层等。
• Positive photosensitive polyimide resin composition
  申请人：NISSAN CHEMICAL INDUSTRIES LTD.

  公开号：EP0424940A2

  公开（公告）日：1991-05-02

  A positive photosensitive polyimide resin composition which comprises 100 parts by weight of an organic solvent-soluble polyimide resin and 1-100 parts by weight of an ο-quinonediazide compound, said polyimide resin being composed of the repeating units represented by formulas [I] and [II] below (where R₁ is a divalent organic group to constitute a diamine which has one or more groups of at least one kind selected from the group consisting of phenolic hydroxyl group, carboxyl group, thiophenol group, and sulfonic group; R₃ is a divalent organic group having no phenolic hydroxyl group, carboxyl group, thiophenol group, and sulfonic group; and R₂ and R₄ each are a tetravalent organic group constituting a tetracarboxylic acid and a derivative thereof when R₁ has one or more groups of at least one kind selected from the group consisting of carboxyl group and sulfonic group and has no phenolic hydroxyl group and thiophenol group, or R₂ and R₄ each are a tetravalent organic group constituting a tetracarboxylic acid and a derivative thereof composed of four carbonyl groups which are not attached directly to the aromatic ring when R₁ has a phenolic hydroxyl group and/or thiophenol group) with the molar percentage (a) of the repeating units represented by formula [I] being in the range of 1 mol% ≦ a ≦ 90 mol% and the molar percentage (b) of the repeating units represented by formula [II] being in the range of 10 mol% ≦ b ≦ 99 mol%, and having a reduced viscosity of 0.05-3.0 dℓ/g (measured at a concentration of 0.5 g/ℓ in N-methylpyrrolidone at 30°C).

  一种正性光敏聚酰亚胺树脂组合物，它由重量份数为 100 份的有机溶剂溶性聚酰亚胺树脂和重量份数为 1-100 份的ο-醌噻嗪化合物组成，所述聚酰亚胺树脂由以下式[I]和[II]所代表的重复单元组成 (其中，R₁ 是二价有机基团，以构成二元胺，该二元胺具有一个或多个至少选自酚羟基、羧基、噻吩酚基和磺酸基的基团；R₃ 是不含酚羟基、羧基、噻吩酚基和磺酸基的二价有机基团；和 R₂ 和 R₄ 分别是构成四羧酸及其衍生物的四价有机基团，当 R₁ 具有至少一种选自羧基和磺酰基的一个或多个基团，且不具有酚羟基和噻吩酚基时、或 R₂ 和 R₄ 各为构成四羧酸的四价有机基团及其衍生物，当 R₁ 具有酚羟基和/或噻吩酚基时，由四个不直接连接到芳香环上的羰基组成。） 由式[I]代表的重复单元的摩尔百分比（a）在 1 mol% ≦ a ≦ 90 mol% 的范围内，由式[II]代表的重复单元的摩尔百分比（b）在 10 mol% ≦ b ≦ 99 mol% 的范围内，且具有 0.05-3.0dℓ/g（在N-甲基吡咯烷酮中浓度为0.5g/ℓ，温度为30℃时测量）。