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1-piperidin-3-yl-1,3-dihydro-benzoimidazol-2-one | 80119-33-1

中文名称
——
中文别名
——
英文名称
1-piperidin-3-yl-1,3-dihydro-benzoimidazol-2-one
英文别名
1,3-dihydro-1-(3-piperidinyl)-2H-Benzimidazol-2-one;3-piperidin-3-yl-1H-benzimidazol-2-one
1-piperidin-3-yl-1,3-dihydro-benzoimidazol-2-one化学式
CAS
80119-33-1
化学式
C12H15N3O
mdl
——
分子量
217.271
InChiKey
WNCXNXMCYPQBPT-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    0.9
  • 重原子数:
    16
  • 可旋转键数:
    1
  • 环数:
    3.0
  • sp3杂化的碳原子比例:
    0.42
  • 拓扑面积:
    44.4
  • 氢给体数:
    2
  • 氢受体数:
    2

反应信息

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文献信息

  • 2-OXOIMIDAZOLE DERIVATIVES
    申请人:BANYU PHARMACEUTICAL CO., LTD.
    公开号:EP0990653A1
    公开(公告)日:2000-04-05
    The present invention relates to a compound represented by Formula [I] [wherein represents an aromatic carbo- or heterocyclic ring which may have a substituent; Cy represents a mono-, bi- or tricyclic aliphatic carbocyclic group having 3 to 20 carbon atoms, which may have a substituent; represents a mono- or bicyclic aliphatic nitrogen-containing heterocyclic group having 3 to 14 carbon atoms, which may have a substituent; R1 represents a hydrogen atom, a lower alkenyl group, a lower alkynyl group, a cyclo(lower alkyl) group, an amino group, a lower alkylamino group, a di(lower alkyl)amino group, a hydroxyl group, a lower alkoxy group, a carboxyl group, a lower alkoxycarbonyl group, a carbamoyl group, a lower alkylcarbamoyl group or a di(lower alkyl)carbamoyl group, or a lower alkyl group which may have a substituent; and R 2 represents a hydrogen atom or a lower alkyl group], a salt or ester thereof, a production process for the same, and an analgesic, a reliever against tolerance to a narcotic analgesic represented by morphine, a reliever against dependence on a narcotic analgesic represented by morphine, an analgesic enhancer, an antiobestic, a drug for ameliorating brain function, a remedy for schizophrenia, a remedy for Parkinsonism, a remedy for chorea, an antidepressant, a remedy for diabetes insipidus, a remedy for polyuria, or a remedy for hypotension, comprising an effective ingredient of the same.
    本发明涉及一种由式[I]表示的化合物 其中 代表芳香族碳环或杂环,可以有取代基; Cy 代表具有 3 至 20 个碳原子的单环、双环或三环脂族碳环基团,可以有取代基; 代表具有 3 至 14 个碳原子的单环或双环脂族含氮杂环基团,该基团可具有取代基;R1 代表氢原子、低级烯基、低级炔基、环(低级烷基)基团、基、低级烷基基、二(低级烷基)基、羟基、低级烷氧基、羧基、低级烷氧羰基、基甲酰基、低级烷基基甲酰基或二(低级烷基)基甲酰基,或可带有取代基的低级烷基;以及 R 2 代表氢原子或低级烷基],其盐或酯,其生产工艺,以及一种镇痛剂、一种防止对以吗啡为代表的麻醉性镇痛剂产生耐受性的缓解剂、一种防止对以吗啡为代表的麻醉性镇痛剂产生依赖性的缓解剂、一种镇痛增强剂、一种抗抑郁剂、一种改善脑功能的药物、一种治疗精神分裂症的药物、一种治疗帕森病的药物、一种治疗舞蹈症的药物、一种抗抑郁剂、一种治疗糖尿病的药物、一种治疗多尿症的药物或一种治疗低血压的药物,其中包括一种有效成分。
  • 4-Amino-2-(aryl)-butylbenzamides and Their conformationally constrained analogues. Potent antagonists of the human neurokinin-2 (NK2) receptor
    作者:A.Roderick MacKenzie、Allan P. Marchington、Donald S. Middleton、Sandra D. Newman、Christopher N. Selway、Nicholas K. Terrett
    DOI:10.1016/s0960-894x(03)00343-3
    日期:2003.7
    A library, evaluating a range of piperazines, piperidines and acyclic amines, as replacements for the 4-hydroxy-4-phenylpiperidine moiety in lead (1b) was prepared. These efforts identified the 4-((N)-benzimidazolone)piperidine analogue (2a) which was further optimised using classical single-compound synthesis to yield the 3-((N)-morpholino)azetidine (2j). Conformationally constrained analogues of (2j), generally offered no potency advantage in this particular series. (C) 2003 Elsevier Science Ltd. All rights reserved.
  • US6258825B1
    申请人:——
    公开号:US6258825B1
    公开(公告)日:2001-07-10
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