1-(N-phenylbenzimidoyl)thiourea | 20800-33-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 1-(N-phenylbenzimidoyl)thiourea
• 英文别名: (N-phenylbenzimidoyl)thiourea；N-phenyl-N'-thiocarbamoyl-benzamidine；N--thioharnstoff；N-(N-Phenyl-benzimidoyl)-thioharnstoff；(Z)-[anilino(phenyl)methylidene]thiourea
• CAS: 20800-33-3
• 化学式: C₁₄H₁₃N₃S
• 分子量: 255.343
• InChiKey: YEDWMNOEZVHVMT-UHFFFAOYSA-N

物化性质

• 熔点：
  166-167 °C(Solv: methanol (67-56-1))
• 沸点：
  413.7±28.0 °C(Predicted)
• 密度：
  1.18±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  82.5
• 氢给体数：
  2
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(N-phenylbenzimidoyl)thiourea 在 sodium perchlorate 、 溴 作用下， 以79%的产率得到5-amino-2,3-diphenyl-1,2,4-thiadiazolium perchlorate
  参考文献：
  名称：

  Zyabrev, V.S.; Kharchenko, A.V.; Pirozhenko, V.V., Journal of Organic Chemistry USSR (English Translation), 1988, vol. 24, p. 1583 - 1590

  摘要：

  DOI：
• 作为产物：
  描述：

  N-苯基亚胺苄基氯 在 氨 作用下， 以 水 、 丙酮 为溶剂， 生成 1-(N-phenylbenzimidoyl)thiourea
  参考文献：
  名称：

  5-Imino-1,2,4-Thiadiazoles: First Small Molecules As Substrate Competitive Inhibitors of Glycogen Synthase Kinase 3

  摘要：

  Cumulative evidence strongly supports that glycogen synthase kinase-3 (GSK-3) is a pathogenic molecule when it is up-dysregulated, emerging as an important therapeutic target in severe unmet human diseases. GSK-3 specific inhibitors might be promising effective drugs for the treatment of devastating pathologies such as neurodegenerative diseases, stroke, and mood disorders. As GSK-3 has the ability to phosphorylate primed substrates, small molecules able to bind to this site should be perfect drug candidates, able to partially block the activity of the enzyme over some specific substrates. Here, we report substituted 5-imino-1,2,4-thiadiazoles as the first small molecules able to inhibit GSK-3 in a substrate competitive manner. These compounds are cell permeable, able to decrease inflammatory activation and to selectively differentiate neural stem cells. Overall, 5-imino-1,2,4-thiadiazoles are presented here as new molecules able to decrease neuronal cell death and to increase endogenous neurogenesis blocking the GSK-3 substrate site

  DOI：

  10.1021/jm201463v

文献信息

• METHODS OF DEGRADING ORGANIC POLLUTANTS AND PREVENTING OR TREATING MICROBE USING Bi2S3-CdS PARTICLES
  申请人：Imam Abdulrahman Bin Faisal University

  公开号：US20200102228A1

  公开（公告）日：2020-04-02

  Methods of synthesizing Bi 2 S 3 —CdS particles in the form of spheres as well as properties of these Bi 2 S 3 —CdS particles are described. Methods of photocatalytic degradation of organic pollutants employing these Bi 2 S 3 —CdS particles and methods of preventing or reducing microbial growth on a surface by applying these Bi 2 S 3 —CdS particles in the form of a solution or an antimicrobial product onto the surface are also specified.

  本文描述了合成球形Bi2S3-CdS颗粒的方法以及这些颗粒的性质。还介绍了利用这些 -CdS颗粒进行光催化降解有机污染物的方法，以及通过将这些 -CdS颗粒以溶液或抗微生物产品的形式涂布在表面上来防止或减少微生物生长的方法。
• Extraction–Spectrophotometric Determination of Molybdenum(V) with Imidoyl Derivatives and Thiocyanate
  作者：Khageshwar Singh Patel、Rajendra Kumar Mishra

  DOI：10.1246/bcsj.56.2811

  日期：1983.9

  organic reagents derived from N-phenylbenzimidoyl chloride and thiourea, phenylthiourea or thiosemicarbazide react with Mo(V) in strongly acidic media in the presence of thiocyanate ions to give rise red-orange complexes, insoluble in water but soluble in benzene. The nature of the ligands has been described to be as univalent, bidentate chelating agents which may coordinate to Mo(V) to form complexes with

  来自 N-苯基苯并亚氨基酰氯和硫脲、苯基硫脲或氨基硫脲的三种新型有机试剂在强酸性介质中在硫氰酸根离子存在下与 Mo(V) 反应生成红橙色络合物，不溶于水但溶于苯。配体的性质已被描述为单价双齿螯合剂，可与 Mo(V) 配位以与 Mo 0.2SCN·SR 的组成形成络合物（SCN 表示硫氰酸根离子，SR 表示试剂的去质子化形式） . 发现配合物的摩尔吸收率在 (0.8–1.4)×104 l mol-1 cm-1 范围内，λmax, 465 nm。该方法简单、快速，对钼的选择性高。与金属相关的铁合金元素不干扰测定。
• Methods of degrading organic pollutants and preventing or treating microbe using Bi2S3-CdS particles
  申请人：Imam Abdulrahman Bin Faisal University

  公开号：US10934176B2

  公开（公告）日：2021-03-02

  Methods of synthesizing Bi2S3—CdS particles in the form of spheres as well as properties of these Bi2S3—CdS particles are described. Methods of photocatalytic degradation of organic pollutants employing these Bi2S3—CdS particles and methods of preventing or reducing microbial growth on a surface by applying these Bi2S3—CdS particles in the form of a solution or an antimicrobial product onto the surface are also specified.

  描述了合成球状 Bi2S3-CdS 颗粒的方法以及这些 -CdS 颗粒的特性。此外，还说明了利用这些 -CdS 颗粒光催化降解有机污染物的方法，以及通过将这些溶液形式的 -CdS 颗粒或抗菌产品涂抹到表面，防止或减少表面微生物生长的方法。
• Goerdeler,J. et al., Chemische Berichte, 1979, vol. 112, p. 1288 - 1296
  作者：Goerdeler,J. et al.

  DOI：——

  日期：——
• GOERDELER J.; HAAG J.; LOEBACH W., CHEM. BER., 1979, 112, NO 4, 1288-1296
  作者：GOERDELER J.、 HAAG J.、 LOEBACH W.

  DOI：——

  日期：——