phenyl N-(2-aminophenyl)-N-methylcarbamate | 57422-52-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: phenyl N-(2-aminophenyl)-N-methylcarbamate
• CAS: 57422-52-3
• 化学式: C₁₄H₁₄N₂O₂
• 分子量: 242.277
• InChiKey: YPGWFNIGPADNPQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.07
• 拓扑面积：
  55.6
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  phenyl N-(2-aminophenyl)-N-methylcarbamate 生成 苯酚
  参考文献：
  名称：

  FIFE T. H.; HUTCHINS J. E. C.; WANG M. S., J. AMER. CHEM. SOC. , 1975, 97, NO 20, 5878-5882

  摘要：

  DOI：
• 作为产物：
  描述：

  N-甲基-2-硝基苯胺 、 氯甲酸苯酯 生成 phenyl N-(2-aminophenyl)-N-methylcarbamate
  参考文献：
  名称：

  Highly efficient intramolecular nucleophilic reactions. Cyclization of p-nitrophenyl N-(2-mercaptophenyl)-N-methylcarbamate and phenyl N-(2-aminophenyl)-N-methylcarbamate

  摘要：

  DOI：

  10.1021/ja00853a038

文献信息

• Selective cellular targeting: multifunctional delivery vehicles, multifunctional prodrugs, use as antineoplastic drugs
  申请人：Drug Innovation & Design, Inc.

  公开号：US20030138432A1

  公开（公告）日：2003-07-24

  The present invention relates to the compositions, methods, and applications of a novel approach to selective cellular targeting. The purpose of this invention is to enable the selective delivery and/or selective activation of effector molecules to target cells for diagnostic or therapeutic purposes. The present invention relates to multi-functional prodrugs or targeting vehicles wherein each functionality is capable of enhancing targeting selectivity, affinity, intracellular transport, activation or detoxification. The present invention also relates to ultra-low dose, multiple target, multiple drug chemotherapy and targeted immunotherapy for cancer treatment.

  本发明涉及一种新的选择性细胞靶向的组合物、方法和应用。本发明的目的是为了实现对目标细胞的选择性输送和/或选择性激活效应分子，以进行诊断或治疗。本发明涉及多功能前药或靶向载体，其中每个功能都能增强靶向选择性、亲和力、细胞内转运、激活或解毒。本发明还涉及超低剂量、多靶点、多药物化疗和靶向免疫疗法，用于癌症治疗。
• Exponential pattern recognition based cellular targeting, compositions, methods and anticancer applications
  申请人：Drug Innovation & Design, Incorporated

  公开号：US20030031677A1

  公开（公告）日：2003-02-13

  The present invention relates to the compositions, methods, and applications of a new approach to pattern recognition based targeting by which an exponential amplification of effector response can be specifically obtained at a targeted cells. The purpose of this invention is to enable the selective delivery of large quantities of an array of effector molecules to target cells for diagnostic or therapeutic purposes. The invention is comprised of two components designated as “Compound 1” and “Compound 2”: Compound 1 is comprised of a cell binding agent and a masked female adaptor. Compound 2 is comprised of a male ligand, an effector agent, and two or more masked female receptors. The male ligand is selected to bind with high affinity to the female adaptor. Compound 1 can bind with high affinity to the target cell and the female receptor can then be unmasked by an enzyme enriched at the tumor cell. The male ligand of Compound 2 can then bind to the unmasked female adaptor bound to the target cell. The masked female adaptor on the bound Compound 2 can then be specifically unmasked. One receptor has in effect become two. Two new molecules of Compound 2 can bind to the unmasked adaptors receptors. After unmasking two receptors in effect become four. The process can continue in an explosive exponential like fashion resulting in enormous amplification of the number of effector molecules specifically deposited at the target cell.

  本发明涉及一种基于模式识别的靶向新方法的成分、方法和应用，通过这种方法可以在靶细胞上特异性地获得指数放大的效应反应。本发明的目的是将大量效应分子阵列选择性地传递到靶细胞，以达到诊断或治疗的目的。本发明由两种成分组成，分别称为 "化合物 1 "和 "化合物 2"：化合物 1 由细胞结合剂和遮蔽的雌性适配体组成。化合物 2 由一种雄性配体、一种效应剂和两种或两种以上被遮蔽的雌性受体组成。雄性配体可与雌性受体高亲和力结合。化合物 1 能以高亲和力与靶细胞结合，然后雌性受体可被肿瘤细胞中富集的酶解除屏蔽。然后，化合物 2 的雄性配体可与结合到靶细胞上的未被掩蔽的雌性适配体结合。然后，结合在化合物 2 上的被掩蔽的雌性适配体就能被特异性地解除掩蔽。一个受体实际上变成了两个。两个新的化合物 2 分子可以与已解除屏蔽的适配体受体结合。解除屏蔽后，两个受体实际上变成了四个。这一过程会以爆炸性的指数方式持续进行，从而使特异性沉积在靶细胞上的效应分子数量大幅增加。
• Exponential pattern recognition based cellular targeting compositions, methods and anticancer applications
  申请人：Glazier Arnold

  公开号：US20070172422A1

  公开（公告）日：2007-07-26

  The present invention relates to the compositions, methods, and applications of a new approach to pattern recognition based targeting by which an exponential amplification of effector response can be specifically obtained at a targeted cells. The purpose of this invention is to enable the selective delivery of large quantities of an array of effector molecules to target cells for diagnostic or therapeutic purposes. The invention is comprised of two components designated as “Compound 1” and “Compound 2”: Compound 1 is comprised of a cell binding agent and a masked female adaptor. Compound 2 is comprised of a male ligand, an effector agent, and two or more masked female receptors. The male ligand is selected to bind with high affinity to the female adaptor. Compound 1 can bind with high affinity to the target cell and the female receptor can then be unmasked by an enzyme enriched at the tumor cell. The male ligand of Compound 2 can then bind to the unmasked female adaptor bound to the target cell. The masked female adaptor on the bound Compound 2 can then be specifically unmasked. One receptor has in effect become two. Two new molecules of Compound 2 can bind to the unmasked adaptors receptors. After unmasking two receptors in effect become four. The process can continue in an explosive exponential like fashion resulting in enormous amplification of the number of effector molecules specifically deposited at the target cell.