methyl 3-(1-benzamidomethyl)benzoate | 1252933-79-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 3-(1-benzamidomethyl)benzoate
• 英文别名: methyl 3-(benzamidomethyl)benzoate；3-(Benzoylamino-methyl)-benzoic acid methyl ester
• CAS: 1252933-79-1
• 化学式: C₁₆H₁₅NO₃
• 分子量: 269.3
• InChiKey: VBMZNTQYYIMMEZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.12
• 拓扑面积：
  55.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  间氯苯甲酸甲酯 、 potassium N-(trifluoroboratomethyl)benzamide 在 palladium diacetate 、 caesium carbonate 、 2-二环己基磷-2,4,6-三异丙基联苯 作用下， 以 环戊基甲醚 、 水 为溶剂， 反应 6.0h， 以89%的产率得到methyl 3-(1-benzamidomethyl)benzoate
  参考文献：
  名称：

  Synthesis of Amidomethyltrifluoroborates and Their Use in Cross-Coupling Reactions

  摘要：

  Amidomethyltrifluoroborates were successfully synthesized in a one-pot fashion and used in cross-coupling reactions with a wide variety of aryl and heteroaryl chlorides.

  DOI：

  10.1021/ol102039c

文献信息

• [EN] AZAINDOLE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES<br/>[FR] DÉRIVÉS AZAINDOLE UTILISÉS EN TANT QU'INHIBITEURS DE PROTÉINE KINASES
  申请人：ORIBASE PHARMA

  公开号：WO2014102378A1

  公开（公告）日：2014-07-03

  The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the present invention thus also includes the preparation of compounds of formula (I), their uses, in particular in the inhibition of protein kinases which are implicated for example in numerous diseases such as cancers or immune system disorders.

  本发明涉及以下式（I）的化合物和/或药用可接受的加合盐、溶剂化合物、对映体、顺反异构体，以及它们的混合物。因此，本发明的内容还包括制备式（I）化合物，它们的用途，特别是在抑制蛋白激酶方面的用途，该蛋白激酶在诸如癌症或免疫系统紊乱等多种疾病中起作用。
• RHO KINASE INHIBITORS
  申请人：Dahmann Georg

  公开号：US20100041645A1

  公开（公告）日：2010-02-18

  Substituted amide and urea derivatives useful as inhibitors of Rho kinase are described, which inhibitors can be useful in the treatment of various disorders such as cardiovascular diseases, cancer, neurological diseases, renal diseases, bronchial asthma, erectile dysfunction and glaucoma.

  本文介绍了一种替代酰胺和脲衍生物，这些衍生物可用作Rho激酶的抑制剂，在治疗心血管疾病、癌症、神经系统疾病、肾脏疾病、支气管哮喘、勃起功能障碍和青光眼等各种疾病中有用。
• AZAINDOLE DERIVATIVES AS INHIBITORS OF PROTEIN KINASES
  申请人：ORIBASE PHARMA

  公开号：US20150353540A1

  公开（公告）日：2015-12-10

  The present invention relates to compounds of the following formula (I) and/or the pharmaceutically acceptable addition salts, solvates, enantiomers, diastereoisomers thereof, as well as mixtures thereof. The subject matter of the present invention thus also includes the preparation of compounds of formula (I), their uses, in particular in the inhibition of protein kinases which are implicated for example in numerous diseases such as cancers or immune system disorders.

  本发明涉及以下式(I)化合物及/或其药学上可接受的加合物、溶剂化物、对映体、非对映异构体以及它们的混合物。因此，本发明的主题还包括制备式(I)化合物、它们的用途，特别是在抑制蛋白激酶方面的应用，这些蛋白激酶例如与许多疾病（如癌症或免疫系统紊乱）有关。
• Electro/Ni Dual‐Catalyzed Decarboxylative C(sp³)−C(sp²) Cross‐Coupling Reactions of Carboxylates and Aryl Bromide
  作者：Jian Luo、Michael T. Davenport、Daniel H. Ess、T. Leo Liu

  DOI：10.1002/anie.202403844

  日期：——

  Electro/Ni dual-catalyzed redox-neutral C(sp3)−C(sp2) cross-coupling reactions of widely available carboxylate nucleophiles with aryl bromides are developed. The electro/Ni dual-catalyzed redox-neutral cross-coupling expands the chemical space of paired electrosynthesis and represents a sustainable method for the construction of the C(sp3)−C(sp2) bond.

  开发了广泛使用的羧酸盐亲核试剂与芳基溴的电/镍双催化氧化还原中性 C（sp3）−C（sp2） 交叉偶联反应。电/Ni 双催化氧化还原中叉偶联扩展了成对电合成的化学空间，代表了构建 C（sp3）−C（sp2） 键的可持续方法。
• US9493455B2
  申请人：——

  公开号：US9493455B2

  公开（公告）日：2016-11-15