2-(benzhydrylthio)-1-methyl-1H-indole | 1268636-32-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(benzhydrylthio)-1-methyl-1H-indole
• 英文别名: 2-Benzhydrylsulfanyl-1-methylindole；2-benzhydrylsulfanyl-1-methylindole
• CAS: 1268636-32-3
• 化学式: C₂₂H₁₉NS
• 分子量: 329.466
• InChiKey: YRMKFXNMOJSZHB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  24
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.09
• 拓扑面积：
  30.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二苯甲醇 、 1-甲基-1,3-二氢吲哚-2-硫酮 在 ytterbium(III) triflate 作用下， 以 1,4-二氧六环 为溶剂， 反应 1.0h， 以91%的产率得到2-(benzhydrylthio)-1-methyl-1H-indole
  参考文献：
  名称：

  Yttrium triflate-catalyzed efficient chemoselective S-benzylation of indoline-2-thiones using benzyl alcohols

  摘要：

  A highly efficient yttrium triflate-catalyzed chemoselective S-benzylation of indolin-2-thiones using variously substituted benzyl alcohols has been developed for the synthesis of indole-based sulfides. This procedure presents a greener approach for the synthesis of S-alkylated indoles. The reaction condition is amenable to primary, secondary, and tertiary benzylic alcohols as the benzyl group donors. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.11.163

文献信息

• Yttrium triflate-catalyzed efficient chemoselective S-benzylation of indoline-2-thiones using benzyl alcohols
  作者：Mukund Jha、Oro Enaohwo、Stephanie Guy

  DOI：10.1016/j.tetlet.2010.11.163

  日期：2011.2

  A highly efficient yttrium triflate-catalyzed chemoselective S-benzylation of indolin-2-thiones using variously substituted benzyl alcohols has been developed for the synthesis of indole-based sulfides. This procedure presents a greener approach for the synthesis of S-alkylated indoles. The reaction condition is amenable to primary, secondary, and tertiary benzylic alcohols as the benzyl group donors. (C) 2010 Elsevier Ltd. All rights reserved.