3-(4-chlorophenyl)-3-hydroxy-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one | 850903-64-9

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: 3-(4-chlorophenyl)-3-hydroxy-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
• 英文别名: 3-(4-Chlorophenyl)-3-hydroxy-5-methoxy-2-phenylisoindol-1-one
• CAS: 850903-64-9
• 化学式: C₂₁H₁₆ClNO₃
• 分子量: 365.816
• InChiKey: ZMACVMBAZFBBDH-UHFFFAOYSA-N

物化性质

• 熔点：
  234-237 °C(Solv: methanol (67-56-1); water (7732-18-5))
• 沸点：
  581.0±50.0 °C(Predicted)
• 密度：
  1.376±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  3-(4-chlorophenyl)-3-hydroxy-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one 在 一水合肼 作用下， 以 甲醇 、 丙醇 、 水 为溶剂， 反应 231.5h， 生成 4-(4-chlorophenyl)-2-(dimethylaminomethyl)-6-methoxy-2H-phtalazin-1-one
  参考文献：
  名称：

  A Practical Approach for Preparation of 2‐[(Dialkylamino)‐methyl]‐4‐aryl‐2H‐phthalazin‐1‐ones via Mannich Reaction of 4‐Aryl‐2H‐phthalazin‐1‐ones

  摘要：

  Synthesis of 4-aryl-2H-phthalazin-1-ones 5 and their successive conversion, via the Mannich reaction into 2-[(dialkylamino)-methyl]-4-aryl-2H-phthalazin-1-ones 6, 7, 8, 9 as a way of regiospecific transformation of the 4-methoxybenzanilide 1, is described. In addition, the compounds 5b and 7 appeared to be effective complexing ligands for such metal as Cu(II), Ni(II), Fe(II), and Fe(III).

  DOI：

  10.1081/scc-200048404
• 作为产物：
  描述：

  对氯苯甲酸甲酯 、 以 四氢呋喃 、 正己烷 为溶剂， 以60%的产率得到3-(4-chlorophenyl)-3-hydroxy-5-methoxy-2-phenyl-2,3-dihydro-1H-isoindol-1-one
  参考文献：
  名称：

  A Practical Approach for Preparation of 2‐[(Dialkylamino)‐methyl]‐4‐aryl‐2H‐phthalazin‐1‐ones via Mannich Reaction of 4‐Aryl‐2H‐phthalazin‐1‐ones

  摘要：

  Synthesis of 4-aryl-2H-phthalazin-1-ones 5 and their successive conversion, via the Mannich reaction into 2-[(dialkylamino)-methyl]-4-aryl-2H-phthalazin-1-ones 6, 7, 8, 9 as a way of regiospecific transformation of the 4-methoxybenzanilide 1, is described. In addition, the compounds 5b and 7 appeared to be effective complexing ligands for such metal as Cu(II), Ni(II), Fe(II), and Fe(III).

  DOI：

  10.1081/scc-200048404

文献信息

• A Practical Approach for Preparation of 2‐[(Dialkylamino)‐methyl]‐4‐aryl‐2<i>H</i>‐phthalazin‐1‐ones via Mannich Reaction of 4‐Aryl‐2<i>H</i>‐phthalazin‐1‐ones
  作者：Jan Epsztajn、Zbigniew Malinowski、Paweł Urbaniak、Grzegorz Andrijewski

  DOI：10.1081/scc-200048404

  日期：2005.1

  Synthesis of 4-aryl-2H-phthalazin-1-ones 5 and their successive conversion, via the Mannich reaction into 2-[(dialkylamino)-methyl]-4-aryl-2H-phthalazin-1-ones 6, 7, 8, 9 as a way of regiospecific transformation of the 4-methoxybenzanilide 1, is described. In addition, the compounds 5b and 7 appeared to be effective complexing ligands for such metal as Cu(II), Ni(II), Fe(II), and Fe(III).