2-isopropylphenyl 4-methylphenyl sulfide | 880640-87-9

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醚类
• 英文名称: 2-isopropylphenyl 4-methylphenyl sulfide
• 英文别名: 1-[(4-Methylphenyl)sulfanyl]-2-(propan-2-yl)benzene；1-methyl-4-(2-propan-2-ylphenyl)sulfanylbenzene
• CAS: 880640-87-9
• 化学式: C₁₆H₁₈S
• 分子量: 242.385
• InChiKey: ZLNNEZDNLYUUGT-UHFFFAOYSA-N

物化性质

• 沸点：
  328.6±21.0 °C(Predicted)
• 密度：
  1.05±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  5.5
• 重原子数：
  17
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  25.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  对氯甲苯 、 2-异丙基苯硫酚 在 CyPF-t-Bu 、 potassium tert-butylate 、 bis(dibenzylideneacetone)-palladium⁽⁰⁾ 作用下， 以 甲苯 为溶剂， 以97%的产率得到2-isopropylphenyl 4-methylphenyl sulfide
  参考文献：
  名称：

  用于芳基卤化物与硫醇的钯催化偶联的通用且长寿命的催化剂

  摘要：

  报道了基于使用 CyPF-t-Bu 配体 (1) 将芳基卤化物和磺酸盐与硫醇偶联的通用催化系统。由 1 的配合物催化的反应以优异的产率和广泛的范围发生，并表现出非凡的转换数和高官能团耐受性。营业额通常比以前的催化剂高出 2 或 3 个数量级。此外，首次报道了芳基甲苯磺酸酯与烷烃硫醇形成芳基硫化物的反应。最后，使用硫化氢替代物完成了由两种溴芳烃合成二芳基硫化物。

  DOI：

  10.1021/ja0580340

文献信息

• A General, Efficient, and Functional-Group-Tolerant Catalyst System for the Palladium-Catalyzed Thioetherification of Aryl Bromides and Iodides
  作者：Manuel A. Fernández-Rodríguez、John F. Hartwig

  DOI：10.1021/jo802594d

  日期：2009.2.20

  reaction of aryl bromides and iodides with aliphatic and aromatic thiols catalyzed by palladium complexes of the bisphosphine ligand CyPF-tBu (1) is reported. Reactions occur in excellent yields, broad scope, high tolerance of functional groups, and with turnover numbers that exceed those of previous catalysts by 2 or 3 orders of magnitude. These couplings of bromo- and iodoarenes are more efficient than

  报道了由双膦配体 CyPF- t Bu ( 1 )的钯配合物催化的芳基溴化物和碘化物与脂肪族和芳香族硫醇的交叉偶联反应。反应以优异的产率、广泛的范围、高的官能团耐受性以及比以前催化剂高出 2 或 3 个数量级的周转数发生。这些溴代芳烃和碘代芳烃的偶联比氯芳烃的相应反应更有效，并且可以在较少的催化剂负载和/或更温和的反应条件下进行。因此，以前在芳基氯偶联中报道的范围和官能团耐受性的限制现在得到了克服。
• Highly Efficient and Functional-Group-Tolerant Catalysts for the Palladium-Catalyzed Coupling of Aryl Chlorides with Thiols
  作者：Manuel A. Fernández-Rodríguez、Qilong Shen、John F. Hartwig

  DOI：10.1002/chem.200600949

  日期：2006.10.16

  The cross-coupling reaction of aryl chlorides with aliphatic and aromatic thiols catalyzed by palladium complexes of the strongly binding bisphosphine CyPF-tBu ligand (1) is reported. Most of the reactions catalyzed by complexes of ligand 1 occur with turnover numbers that exceed those of previous catalysts by two orders of magnitude. The reactions occur with excellent yields, broad scope and high

  据报道，芳基氯化物与强结合双膦CyPF-tBu配体（1）的钯配合物催化的脂族和芳族硫醇的交叉偶联反应。由配体1的配合物催化的大多数反应发生的周转数比先前催化剂的周转数高两个数量级。反应以优异的收率，广泛的范围和对官能团的高耐受性进行。还描述了在低负载量下衍生自其他Josiphos型配体以及其他结构类型的配体的芳基卤化物与硫醇的偶联。
• Substituted acid derivatives useful as antidiabetic and antiobesity agents and method
  申请人：Cheng T. Peter

  公开号：US20070015797A1

  公开（公告）日：2007-01-18

  Compounds are provided which have the structure wherein Q is C or N, A is O or S, Z is O or a bond, X is CH or N and R 1 , R 2 , R 2a , R 2b , R 2c , R 3 , Y, x, m, and n are as defined herein, which compounds are useful as antidiabetic, hypolipidemic, and antiobesity agents.

  提供了一些化合物，它们的结构如下：其中Q为C或N，A为O或S，Z为O或键，X为CH或N，R1、R2、R2a、R2b、R2c、R3、Y、x、m和n如此定义，这些化合物可用作抗糖尿病、降脂和抗肥胖药物。
• Application of hydrazone ligands in Chan−Lam coupling of arylboronic acids and thiols
  作者：Legen Hu、Jiaquan Wang、Kelun Cui、Lin Zheng、Chunyin Zhu

  DOI：10.1016/j.tet.2024.133945

  日期：2024.4

  A Cu/hydrazone catalysis has been applied in the oxidative coupling of arylboronic acids and aromatic thiols for the synthesis of asymmetric diaryl sulfides. The reaction features mild conditions and readily available hydrazone ligand. It works for a wide range of arylboronic acids and thiols with good to excellent yields, exhibiting great potential of such hydrazone ligands in organic synthesis.

  Cu/腙催化已应用于芳基硼酸和芳香硫醇的氧化偶联，以合成不对称二芳基硫醚。该反应条件温和，腙配体易于获得。它适用于多种芳基硼酸和硫醇，具有良好至优异的产率，展示了此类腙配体在有机合成中的巨大潜力。
• Cobalt-Catalyzed Aryl−Sulfur Bond Formation
  作者：Ying-Chieh Wong、Thiruvellore Thatai Jayanth、Chien-Hong Cheng

  DOI：10.1021/ol062344l

  日期：2006.11.1

  A new cobalt-catalyzed coupling of aryl halides with thiophenols and alkanethiols is reported. A variety of aryl sulfides can be prepared in excellent yields under mild reaction conditions using 1-2 mol % of Col(2)(dppe) and Zn. This new cobalt-catalyzed coupling represents an interesting addition to previously known methods to synthesize thioethers.