2-[(3-氟苯基)氨基甲酰]苯甲酸 | 19336-76-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 2-[(3-氟苯基)氨基甲酰]苯甲酸
• 英文名称: N-(3-Fluoro-phenyl)-phthalamic acid
• 英文别名: 2-[(3-Fluorophenyl)carbamoyl]benzoic acid
• CAS: 19336-76-6
• 化学式: C₁₄H₁₀FNO₃
• 分子量: 259.237
• InChiKey: LRJULBZGMQWDBQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  19
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  66.4
• 氢给体数：
  2
• 氢受体数：
  4

安全信息

• 海关编码：
  2924299090

反应信息

• 作为产物：
  描述：

  苯酐 、 3-氟苯胺 反应 0.03h， 以91%的产率得到2-[(3-氟苯基)氨基甲酰]苯甲酸
  参考文献：
  名称：

  Microwave assisted synthesis of N-Arylphthalamic acids with hyperlipidemic activity

  摘要：

  A series of substituted N-arylphthalamic acids 3a-i has been synthesized by the reaction of phthalic anhydride 1 and aryl- or heterocyclic amines 2a-i, in the absence of solvents, in a domestic microwave oven. The formation of nine N-arylphthalamic acids was accomplished in 1-3 min giving excellent yields for compounds 3a-g, but moderate yield of compounds 3h and 3i, respectively. Compounds 3h and 3i are new. Interestingly, N-arylphthalamic acids 3a-i induced hyperlipidemia in Swiss white mice and also increased animals' body weight. (C) 2001 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(01)00540-6

文献信息

• PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES
  申请人：Semple J. Edward

  公开号：US20120108592A1

  公开（公告）日：2012-05-03

  A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.

  描述了一类新的水杨酰苯胺类化合物。这些化合物对肝炎病毒表现出强大的活性。
• [EN] PHTHALANILATE COMPOUNDS AND METHODS OF USE<br/>[FR] COMPOSÉS DE PHTALANILATE ET LEURS PROCÉDÉS D'UTILISATION
  申请人：UNIV NOTRE DAME DU LAC

  公开号：WO2011026107A1

  公开（公告）日：2011-03-03

  The invention provides antimicrobial compounds and compositions, and methods of using them. The compounds and compositions include, for example, a compound of any one of Formulas I-X. The invention further provides methods of preparing the compounds, and useful intermediates for their preparation. The compounds can possess highly specific and selective activity, such as antibacterial activity and/or enzymatic inhibitory activity. Accordingly, the compounds and compositions can be used to treat bacterial infections, or to inhibit or kill bacteria, either in vitro or in vivo.

  本发明提供了抗微生物化合物和组合物，以及使用它们的方法。这些化合物和组合物包括，例如，I-X公式中的任何一种化合物。本发明进一步提供了制备这些化合物的方法，并提供了有用的中间体。这些化合物可以具有高度特异性和选择性活性，例如抗菌活性和/或酶抑制活性。因此，这些化合物和组合物可以用于治疗细菌感染，或者在体外或体内抑制或杀死细菌。
• [EN] NITROGEN-CONTAINING HETEROCYCLIC COMPOUND, PREPARATION METHOD THEREFOR, AND APPLICATION THEREOF<br/>[FR] COMPOSÉ HÉTÉROCYCLIQUE CONTENANT DE L'AZOTE, PROCÉDÉ DE PRÉPARATION CORRESPONDANT ET UTILISATION ASSOCIÉE<br/>[ZH] 一种含氮杂环化合物、其制备方法及应用
  申请人：JIANGSU KDN PHARMACEUTICAL TECH CO LTD

  公开号：WO2020124500A1

  公开（公告）日：2020-06-25

  本发明公开了一种含氮杂环化合物、其制备方法及应用。本发明提供了一种如式I所示的含氮杂环化合物、其药学上可接受的盐、其水合物、其溶剂化物、其多晶型、其代谢产物、其立体异构体、其互变异构体或其前药。该含氮杂环化合物具有诱导刺激间充质干细胞(MSC)分化成软骨细胞，修复软骨的应用。还提供了治疗、预防或改善关节炎或关节损伤的组合物和方法，通过本发明的化合物或组合物施用于关节、软骨组织或软骨近端组织或全身来进行。本发明还提供用于诱导间充质干细胞(MSC)分化成软骨细胞的组合物和方法。
• [EN] PHARMACEUTICAL COMPOSITIONS AND METHODS OF USE OF SALICYLANILIDES FOR TREATMENT OF HEPATITIS VIRUSES<br/>[FR] COMPOSITIONS PHARMACEUTIQUES ET PROCÉDÉS D'UTILISATION DE SALICYLANILIDES POUR TRAITEMENT DE VIRUS DE L'HÉPATITE
  申请人：ROMARK LAB LC

  公开号：WO2012058378A1

  公开（公告）日：2012-05-03

  A new class of salicylanilides is described. These compounds show strong activity against hepatitis viruses.
• Microwave assisted synthesis of N-Arylphthalamic acids with hyperlipidemic activity
  作者：Vera L.M Sena、Rajendra M Srivastava、Shalom P Oliveira、Vera L.M Lima

  DOI：10.1016/s0960-894x(01)00540-6

  日期：2001.10

  A series of substituted N-arylphthalamic acids 3a-i has been synthesized by the reaction of phthalic anhydride 1 and aryl- or heterocyclic amines 2a-i, in the absence of solvents, in a domestic microwave oven. The formation of nine N-arylphthalamic acids was accomplished in 1-3 min giving excellent yields for compounds 3a-g, but moderate yield of compounds 3h and 3i, respectively. Compounds 3h and 3i are new. Interestingly, N-arylphthalamic acids 3a-i induced hyperlipidemia in Swiss white mice and also increased animals' body weight. (C) 2001 Elsevier Science Ltd. All rights reserved.