N-(2-([1,1'-biphenyl]-4-yloxy)ethyl)-N,4-dimethylbenzenesulfonamide | 1394916-91-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-(2-([1,1'-biphenyl]-4-yloxy)ethyl)-N,4-dimethylbenzenesulfonamide
• 英文别名: N,4-dimethyl-N-[2-(4-phenylphenoxy)ethyl]benzenesulfonamide
• CAS: 1394916-91-6
• 化学式: C₂₂H₂₃NO₃S
• 分子量: 381.496
• InChiKey: PSCLJOBMLOKHPP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  27
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  55
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  4-碘联苯 、 N-2-羟基乙基-N-甲基- 在 bis(2-isobutyrylcyclohexanone) copper 、 caesium carbonate 作用下， 以 1,4-二氧六环 为溶剂， 反应 24.0h， 以83%的产率得到N-(2-([1,1'-biphenyl]-4-yloxy)ethyl)-N,4-dimethylbenzenesulfonamide
  参考文献：
  名称：

  A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings

  摘要：

  A stable adduct of Cul with Bu4NI, soluble in organic solvents, has been identified as an effective catalyst for copper-catalyzed C-N and C-O couplings. In addition, stable nonhygroscopic salts of some high performance ligands (diamine MsOH salts/CuX and copper(II) diketonates) were shown to be of similar and sometimes greater reactivity compared to the literature reagents for these couplings. Furthermore, these more robust conditions result in more reproducible results.

  DOI：

  10.1021/jo300905w

文献信息

• A Soluble Copper(I) Source and Stable Salts of Volatile Ligands for Copper-Catalyzed C–X Couplings
  作者：Peter E. Maligres、Shane W. Krska、Peter G. Dormer

  DOI：10.1021/jo300905w

  日期：2012.9.7

  A stable adduct of Cul with Bu4NI, soluble in organic solvents, has been identified as an effective catalyst for copper-catalyzed C-N and C-O couplings. In addition, stable nonhygroscopic salts of some high performance ligands (diamine MsOH salts/CuX and copper(II) diketonates) were shown to be of similar and sometimes greater reactivity compared to the literature reagents for these couplings. Furthermore, these more robust conditions result in more reproducible results.