2,6-dimethyl-4-((dodecylthio)methyl)phenol | 944389-90-6

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: 2,6-dimethyl-4-((dodecylthio)methyl)phenol
• 英文别名: dodecyl 3,5-dimethyl-4-hydroxybenzyl sulfide；4-(dodecylthiomethyl)-2,6-dimethylphenol；4-(Dodecylsulfanylmethyl)-2,6-dimethylphenol
• CAS: 944389-90-6
• 化学式: C₂₁H₃₆OS
• 分子量: 336.582
• InChiKey: QEYHDXVEFOPZSL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  8.3
• 重原子数：
  23
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  45.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  十二硫醇 在 溶剂黄146 作用下， 以 乙醇 为溶剂， 反应 2.0h， 生成 2,6-dimethyl-4-((dodecylthio)methyl)phenol
  参考文献：
  名称：

  苯酚硫甲基化的新方法

  摘要：

  烷基二乙氨基甲基硫化物是将烷硫基甲基引入苯酚的方便有效的试剂。

  DOI：

  10.1007/s11172-010-0175-3

文献信息

• Catalytic Thioalkylation of Phenols Based on Mannich‐Type Phenol
  作者：Peng Liu、Lunyu Zhu、Yan Fang、Huaiping Zhang、Dehong Chen、Tao He、Mingcai Chen、Kai Xu

  DOI：10.1080/00397910701462971

  日期：2007.8

  A thioalkylation of phenols involving reactive phenols, aldehydes, and thiols is described under Mannich-type phenol catalysis to afford thiomethyl phenols in good yields.
• New promising antioxidants based on 2,6-dimethylphenol
  作者：E. A. Kemeleva、E. A. Vasyunina、O. I. Sinitsina、A. S. Khomchenko、M. A. Gross、N. V. Kandalintseva、A. E. Prosenko、G. A. Nevinskii

  DOI：10.1134/s106816200804016x

  日期：2008.7

  Three new sulfur-containing derivatives of 2,6-dimethylphenol were synthesized. Their antioxidative activity, mutagenicity, and genotoxicity were examined by bacterial tests and by calculating the dominant lethal mutations in murine embryonic cells. It was shown that all the compounds synthesized have a marked antioxidative effect and have no genotoxic and mutagenic properties. One of the antioxidants, 4-(3-dodecylthiopropyl)-2,6-dimethylphenol, increases the survival of cells of both the wild-type Escherichia coli strain and bacterial strains defective in the genes of repair enzymes and has a more distinct antioxidative effect than the classic antioxidants alpha-tocopherol and trolox, increasing the survival of cells devoid of repair enzymes.
• Synthesis and investigation of antioxidant properties of alkylated hydroxybenzyl dodecyl sulfides
  作者：A. E. Prosenko、O. I. Dyubchenko、E. I. Terakh、A. F. Markov、E. A. Gorokh、M. A. Boiko

  DOI：10.1134/s0965544106040116

  日期：2006.7

  Various alkyl-substituted hydroxybenzyl dodecyl sulfides were synthesized, and a comparative study of their antiradical activity in the model reaction of initiated styrene oxidation and the overall inhibiting activity in the thermal autooxidation of white mineral oil was carried out.
• METHOD OF FORMING A THREE-DIMENSIONAL ARTICLE HAVING SELECTIVE VISUAL EFFECTS
  申请人：DSM IP Assets B.V.

  公开号：EP2526463B1

  公开（公告）日：2016-07-13
• US3960758A
  申请人：——

  公开号：US3960758A

  公开（公告）日：1976-06-01