Di(2,4,6-trimethylphenyl) phosphoro chloridate | 147263-98-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: Di(2,4,6-trimethylphenyl) phosphoro chloridate
• 英文别名: 2-[Chloro-(2,4,6-trimethylphenoxy)phosphoryl]oxy-1,3,5-trimethylbenzene
• CAS: 147263-98-7
• 化学式: C₁₈H₂₂ClO₃P
• 分子量: 352.798
• InChiKey: TVHUECGOPKCWRM-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.1
• 重原子数：
  23
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  35.5
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  Di(2,4,6-trimethylphenyl) phosphoro chloridate 在 吡啶 、 水 作用下， 反应 0.17h， 以8.9 g的产率得到双(2,4,6-三甲基苯基)磷酸
  参考文献：
  名称：

  Neodymium tris-diarylphosphates: Systematic study of the structure–reactivity relationship in butadiene and isoprene polymerisation

  摘要：

  The catalytic properties of neodymium tris-phosphates with various diarylphosphate ligands in the stereoregular 1,4-cis-polymerisation of butadiene and isoprene were studied. The considerable variability of the diaryl phosphate structure allowed for the systematic investigation of the dependence of the catalytic properties of neodymium tris-diarylphosphates on the electronic and steric properties of the ligand. Electron-withdrawing substituents (F, Cl, Br) in the aryl moiety increased the catalyst activity of tris-diarylphosphate. Neodymium aryl phosphates containing lipophilic bulky ligands provided the synthesis of polydienes with a monomodal molecular-weight distribution. The optimal catalytic properties demonstrated that the neodymium aryl phosphate prepared from bis(2,6-dimethy1-4-tert-butylpheny1)phosphoric acid showed high activity and ensured a monomodal MWD of polydienes (M-w/M-n similar to 2 for polybutadiene and M-w/M-n similar to 3 for polyisoprene) in various conditions. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2014.04.007
• 作为产物：
  描述：

  2,4,6-三甲酚 在 吡啶 、 三氯氧磷 作用下， 以 苯 为溶剂， 反应 5.0h， 生成 Di(2,4,6-trimethylphenyl) phosphoro chloridate
  参考文献：
  名称：

  Neodymium tris-diarylphosphates: Systematic study of the structure–reactivity relationship in butadiene and isoprene polymerisation

  摘要：

  The catalytic properties of neodymium tris-phosphates with various diarylphosphate ligands in the stereoregular 1,4-cis-polymerisation of butadiene and isoprene were studied. The considerable variability of the diaryl phosphate structure allowed for the systematic investigation of the dependence of the catalytic properties of neodymium tris-diarylphosphates on the electronic and steric properties of the ligand. Electron-withdrawing substituents (F, Cl, Br) in the aryl moiety increased the catalyst activity of tris-diarylphosphate. Neodymium aryl phosphates containing lipophilic bulky ligands provided the synthesis of polydienes with a monomodal molecular-weight distribution. The optimal catalytic properties demonstrated that the neodymium aryl phosphate prepared from bis(2,6-dimethy1-4-tert-butylpheny1)phosphoric acid showed high activity and ensured a monomodal MWD of polydienes (M-w/M-n similar to 2 for polybutadiene and M-w/M-n similar to 3 for polyisoprene) in various conditions. (C) 2014 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2014.04.007

文献信息

• Cobalt(II)-Catalyzed Intramolecular C−H Amination with Phosphoryl Azides: Formation of 6- and 7-Membered Cyclophosphoramidates
  作者：Hongjian Lu、Jingran Tao、Jess E. Jones、Lukasz Wojtas、X. Peter Zhang

  DOI：10.1021/ol100110z

  日期：2010.3.19

  A highly effective Co(II)-based system has been developed for catalytic intramolecular C−H amination with phosphoryl azides without the need of terminal oxidant or other additives, resulting in the high-yielding production of cyclophosphoramidates with nitrogen gas as the byproduct. Additional features of this new catalytic system include the amination of primary C−H bonds and formation of 7-membered-ring

  已开发出一种高效的基于Co（II）的系统，用于用磷酰叠氮化物催化分子内CH氨基化反应，而无需末端氧化剂或其他添加剂，从而以氮气为副产物高产环磷酰胺酯。这种新的催化体系的其他特征包括一级CH键的胺化和7元环结构的形成。
• ANTI-CYTOMEGALOVIRUS ACTIVITY OF ARTEMISININ-DERIVED DIMERS
  申请人：Arav-Boger Ravit

  公开号：US20130109654A1

  公开（公告）日：2013-05-02

  Artemisinin-derived monomers and artemisinin dimers are shown to exhibit in-vitro anti-cytomegalovirus (CMV) activity. Artemisinin dimers effectively inhibited CMV replication in human foreskin fibroblasts and human embryonic lung fibroblasts with no cytotoxicity at concentrations required for complete CMV inhibition. Artemisinin dimers were found to be potent and non-cytotoxic inhibitors of CMV replication, which indicates their use as therapeutic agents for the treatment of CMV infection in humans.

  青蒿素衍生单体和青蒿素二聚体表现出体外抗巨细胞病毒（CMV）活性。青蒿素二聚体有效抑制了人阴茎包皮纤维细胞和人胚肺纤维细胞中的CMV复制，且在完全抑制CMV所需的浓度下无细胞毒性。青蒿素二聚体被发现是强效且无细胞毒性的CMV复制抑制剂，这表明它们可用作治疗人类CMV感染的治疗剂。
• High purity sterically hindered diaryl chlorophosphates and method for their preparation
  申请人：General Electric Company

  公开号：US20020013488A1

  公开（公告）日：2002-01-31

  High purity sterically hindered diaryl chlorophosphates, having a purity of at least 98% by weight and a proportion of the corresponding aryl dichlorophosphate less than 1.5% by weight, are prepared by a method including the steps of gradually introducing POCl 3 into a mixture of a sterically hindered hydroxyaromatic compound such as 2,6-xylenol and a catalyst such as magnesium chloride, and gradually increasing the temperature of the reaction mixture to a final level in the range of about 135-150° C. The products are capable of reaction with amines such as piperazine to produce sterically hindered phosphoramidates.

  高纯度立体受阻二芳基氯化磷酸盐的制备方法包括以下步骤：逐渐引入 POCl 3 和催化剂（如氯化镁）的混合物中，并将反应混合物的温度逐渐升高至约 135-150°C 的最终温度。
• Crystalline powders of aromatic diphosphates, their preparation and use
  申请人：DAIHACHI CHEMICAL INDUSTRY CO., LTD.

  公开号：EP0509506B1

  公开（公告）日：1997-06-25
• METHOD FOR PREPARING STERICALLY HINDERED PHOSPHORAMIDATES
  申请人：GENERAL ELECTRIC COMPANY

  公开号：EP1259519A1

  公开（公告）日：2002-11-27