8-(2,3-epoxypropoxy)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine | 91375-79-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并噻嗪类
• 英文名称: 8-(2,3-epoxypropoxy)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine
• 英文别名: 8-(oxiran-2-ylmethoxy)-4H-1,4-benzothiazin-3-one
• CAS: 91375-79-0
• 化学式: C₁₁H₁₁NO₃S
• 分子量: 237.279
• InChiKey: XXYWCAFMZNUAMK-UHFFFAOYSA-N

物化性质

• 沸点：
  455.2±45.0 °C(Predicted)
• 密度：
  1.374±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  76.2
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  8-(2,3-epoxypropoxy)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine 以 丙酮 为溶剂， 反应 2.0h， 生成 8-<3-(3,4-dimethoxyphenyl)ethylamino-2-hydroxy>propoxy-3,4-dihydro-3-oxo-2H(1,4)benzothiazine fumarate
  参考文献：
  名称：

  Cecchetti; Fravolini; Fringuelli, Farmaco, Edizione Scientifica, 1987, vol. 42, # 1, p. 61 - 75

  摘要：

  DOI：
• 作为产物：
  描述：

  8-Amino-2H-<1,4>benzothiazin-3(4H)one 在 sodium hydroxide 、 硫酸 、 sodium nitrite 作用下， 以 甲醇 、 水 、 溶剂黄146 为溶剂， 反应 25.0h， 生成 8-(2,3-epoxypropoxy)-3,4-dihydro-3-oxo-2H-1,4-benzothiazine
  参考文献：
  名称：

  Cecchetti; Fravolini; Fringuelli, Farmaco, Edizione Scientifica, 1987, vol. 42, # 1, p. 61 - 75

  摘要：

  DOI：

文献信息

• (1,4-Benzothiazinyloxy)alkylpiperazine derivatives as potential antihypertensive agents
  作者：Violetta Cecchetti、Fausto Schiaffella、Oriana Tabarrini、Arnaldo Fravolini

  DOI：10.1016/s0960-894x(00)00016-0

  日期：2000.3

  A series of compounds having a piperazine moiety variously linked to the benzothiazine nucleus were synthesized and evaluated for their in vitro alpha-adrenoceptor affinity by radioligand receptor binding assays. Some compounds bearing a oxyalkyl-(2-methoxyphenyl)piperazine side chain were good alpha1-adrenoreceptor ligands.

  合成了具有与苯并噻嗪核不同地连接的哌嗪部分的一系列化合物，并通过放射性配体受体结合测定评估了它们的体外α-肾上腺素受体亲和力。一些带有氧烷基-（2-甲氧基苯基）哌嗪侧链的化合物是良好的α1-肾上腺素受体配体。
• Alkanolaminoxy derivatives of 3,4-dihydro-2H-1,4-benzothiazin-3-one, their production process, and their pharmaceutical use
  申请人：MEDIOLANUM FARMACEUTICI s.r.l.

  公开号：EP0106816A2

  公开（公告）日：1984-04-25

  Object of the invention is a class of new organic compounds derived from 1,4-benzothiazine through substitution of an hydrogen atom in position 6, 7 or 8 by an oxypropanolammine radical monosubstituted in N and furthermore a series of new phenyl derivatives of 1,4-benzothiazine, obtained as intermediate in the synthesis of oxypropanolammine derivatives, and process for obtained the new compounds in form suitable for the preparation of pharmaceutical compositions having antihypertensive, vasodilating and antiarrhythmic activity.

  本发明的目的是一类新的有机化合物，由 1,4-苯并噻嗪通过 6、7 或 8 位上的氢原子被 N 单取代的氧丙醇胺基所取代而得到，此外还有一系列新的 1,4-苯并噻嗪苯基衍生物，这些衍生物在合成氧丙醇胺衍生物的过程中作为中间体而得到，以及获得这些新化合物的工艺，这些新化合物的形式适合于制备具有抗高血压、血管扩张和抗心律失常活性的药物组合物。
• o-Chlorobenzenesulfonamidic derivatives of (aryloxy)propanolamines as .beta.-blocking/diuretic agents
  作者：Violetta Cecchetti、Arnaldo Fravolini、Fausto Schiaffella、Oriana Tabarrini、Giancarlo Bruni、Giorgio Segre

  DOI：10.1021/jm00053a020

  日期：1993.1

  A series of compounds 1b-f, 2b-f, and 3b-f having an o-chlorobenzenesulfonamidic diuretic moiety variously linked to the nitrogen side chain of the beta-blocking (aryloxy)propanolamine pharmacophore were prepared and tested for their beta1-adrenoceptor affinity. For all the active compounds, beta-blocking and diuretic activities were investigated in rats; the structure-activity relationships are discussed Some of the compounds displayed varying levels of both properties and among these, compounds 1c and 2c have been chosen for further development.
• Symbiotic approach to drug design: N-[(4-chloro-3-sulfamoylbenzamido)-ethyl]propanolamine derivatives as β-adrenergic blocking agents with diuretic activity
  作者：V Cecchetti、F Schiaffella、O Tabarrini、W Zhou、A Fravolini、A Goi、G Bruni、G Segre

  DOI：10.1016/0223-5234(91)90098-8

  日期：1991.6

  A series of oxypropanolamines and iminoxypropanolamines, in which the aminic substituent was the 2-(4-chloro-3-sulfamoylbenzamido)-ethyl group, were synthesized as potential beta-blocker/diuretic agents. All of these compounds were tested for beta-1-adrenoceptor affinity and beta-blocking potency. For the most active compounds, diuretic and antihypertensive properties as well as affinity for alpha-1-adrenoceptors were also investigated. Compounds 4 and 10 were found to display contemporaneously beta-blocking, diuretic and antihypertensive activities.
• US4535079A
  申请人：——

  公开号：US4535079A

  公开（公告）日：1985-08-13