2,3,4,5-Tetramethoxy-6-methyl-biphenyl | 842162-30-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2,3,4,5-Tetramethoxy-6-methyl-biphenyl
• 英文别名: 1,2,3,4-Tetramethoxy-5-methyl-6-phenylbenzene；1,2,3,4-tetramethoxy-5-methyl-6-phenylbenzene
• CAS: 842162-30-5
• 化学式: C₁₇H₂₀O₄
• 分子量: 288.343
• InChiKey: WTEHQYYFUUYEON-UHFFFAOYSA-N

物化性质

• 沸点：
  348.9±42.0 °C(Predicted)
• 密度：
  1.079±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  21
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  36.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2,3,4,5-Tetramethoxy-6-methyl-biphenyl 在 ammonium cerium(IV) nitrate 作用下， 以 乙腈 为溶剂， 生成 3,4-dimethoxy-6-methyl-[1,1'-biphenyl]-2,5-dione
  参考文献：
  名称：

  2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity

  摘要：

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.029
• 作为产物：
  描述：

  2,3,4,5-四甲氧基甲苯 在 N-溴代丁二酰亚胺(NBS) 、 四(三苯基膦)钯 、 sodium carbonate 作用下， 以 二氯甲烷 、 苯 为溶剂， 生成 2,3,4,5-Tetramethoxy-6-methyl-biphenyl
  参考文献：
  名称：

  2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity

  摘要：

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2004.12.029

文献信息

• [EN] METHODS FOR PREPARING AND SELECTING PHARMACEUTICALLY USEFUL BRIDGED BIAROMATIC AND TRIAROMATIC RING COMPOUNDS FROM A STRUCTURALLY DIVERSE UNIVERSAL LIBRARY<br/>[FR] PROCEDES DE PREPARATION ET DE SELECTION DE COMPOSES A NOYAUX BIAROMATIQUES ET TRIAROMATIQUES PONTES A PARTIR D'UNE BIBLIOTHEQUE UNIVERSELLE A DIVERSITE STRUCTURELLE
  申请人：——

  公开号：WO1999033431A2

  公开（公告）日：1999-07-08

  [EN] This invention relates to novel combinatorial libraries of bridged biaromatic and triaromatic ring compounds, methods for preparing such libraries, and an apparatus for storing such libraries and for use as a component of assay systems for identifying compounds for drug development.
  [FR] L'invention porte sur de nouvelles bibliothèques combinatoires de composés à noyaux biaromatiques et triaromatiques pontés, sur des procédés de préparation de ces bibliothèques, et sur un appareil de stockage de ces bibliothèques destiné à être utilisé comme composant de systèmes de dosage pour identifier des composés dans le développement de médicaments.
• 2,3-Dimethoxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones: glycation inhibitors with lipid peroxidation activity
  作者：Young-Sik Jung、Bo-Young Joe、Sung Ju Cho、Yasuo Konishi

  DOI：10.1016/j.bmcl.2004.12.029

  日期：2005.2

  Anti-glycation activity of our anti-oxidant quinone library was measured and several 2,3-dimetlioxy-5-methyl-1,4-benzoquinones and 2-methyl-1,4-naphthoquinones were identified as novel inhibitors of glycation, of which 2,3-dimethoxy-5-methyl-1,4-benzoquinones 13b is the most potent glycation inhibitor with around 50 muM of the IC50 value. (C) 2004 Elsevier Ltd. All rights reserved.