2-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate | 160819-61-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-{[(cyclohexyloxy)carbonyl]oxy}ethyl 2-ethoxy-1-{[2'-(1H-tetrazol-5-yl)biphenyl-4-yl]methyl}-1H-benzimidazole-7-carboxylate
• 英文别名: 2-cyclohexyloxycarbonyloxyethyl 2-ethoxy-3-[[4-[2-(2H-tetrazol-5-yl)phenyl]phenyl]methyl]benzimidazole-4-carboxylate
• CAS: 160819-61-4
• 化学式: C₃₃H₃₄N₆O₆
• mdl: MFCD09852494
• 分子量: 610.7
• InChiKey: NQZDOSXQAGAIAB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  45
• 可旋转键数：
  14
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  143
• 氢给体数：
  1
• 氢受体数：
  10

文献信息

• Pharmaceutical composition containing a compound having angiotensin II antagonistic activity in combination with another compound
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP1192951A2

  公开（公告）日：2002-04-03

  To provide a pharmaceutical composition which performs a remarkable effect with a relatively decreased dosage, and, with less side effects, a pharmaceutical composition formulated by combination of an angiotensin II-mediated compound or a salt thereof with at least one species of a compound having the activity of increasing insulin-sensitivity, a compound having the activity of improving postprandial hyperglycemia in diabetes mellitus, an indane derivative having the activity of inhibiting angiotensin converting enzyme, a pyridine derivative having the activity of inhibiting HMG-Co A reductase or salts thereof are advantageously employed.

  提供一种药物组合物，该药物组合物通过将血管紧张素Ⅱ介导的化合物或其盐与至少一种具有提高胰岛素敏感性活性的化合物结合配制而成，这种药物组合物在相对减少用量的情况下具有显著效果，并且副作用较小、可采用具有改善糖尿病餐后高血糖活性的化合物、具有抑制血管紧张素转换酶活性的茚三酮衍生物、具有抑制 HMG-Co A 还原酶活性的吡啶衍生物或其盐。
• PHARMACEUTICAL COMBINATION CONTAINING A COMPOUND HAVING ANGIOTENSIN II AND ANTAGONISTIC ACTIVITY
  申请人：Takeda Chemical Industries, Ltd.

  公开号：EP0914158A2

  公开（公告）日：1999-05-12
• Combination of benzimidazoles having angiotensin-II antagonistic activity with diuretics
  申请人：Takeda Pharmaceutical Company Limited

  公开号：EP1306089B1

  公开（公告）日：2007-09-05
• A PHARMACEUTICAL COMPOSITION CONTAINING CANDESARTAN CILEXETIL AND AMLODIPINE
  申请人：Adamed sp. z o.o.

  公开号：EP2934488A1

  公开（公告）日：2015-10-28
• [EN] PHARMACEUTICAL COMBINATION CONTAINING A COMPOUND HAVING ANGIOTENSIN II AND ANTAGONISTIC ACTIVITY<br/>[FR] COMBINAISON PHARMACEUTIQUE COMPRENANT UN COMPOSE CONTENANT DE L'ANGIOTENSINE II ET PRESENTANT UNE ACTIVITE ANTAGONISTE
  申请人：——

  公开号：WO1997037688A2

  公开（公告）日：1997-10-16

  [EN] To provide a pharmaceutical composition which performs a remarkable effect with a relatively decreased dosage, and, with less side effects, a pharmaceutical composition formulated by combination of an angiotensin II-mediated compound or a salt thereof with at least one species of a compound having the activity of increasing insulin-sensitivity, a compound having the activity of improving postprandial hyperglycemia in diabetes mellitus, an indane derivative having the activity of inhibiting angiotensin converting enzyme, a pyridine derivative having the activity of inhibiting HMG-Co A reductase or salts thereof are advantageously employed.
  [FR] La présente invention concerne une composition pharmaceutique efficace pour un dosage relativement réduit, et présentant moins d'effets secondaires. Pour la formule de cette composition on utilise avantageusement une combinaison entre, d'une part un composé à médiation par l'angiotensine II ou l'un de ses sels, et d'autre part au moins une espèce choisie parmi les composés augmentant la sensibilité à l'insuline, les composés améliorant l'hyperglycémie postprandiale dans le cas du diabète sucré, un dérivé de l'indane inhibant l'enzyme de conversion de l'angiotensine, un dérivé de pyridine inhibant la Co A réductase du HMG, ou l'un de leurs sels.