N-benzyl-4-(4-phenoxyphenyl)thiazol-2-amine | 1262983-57-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-benzyl-4-(4-phenoxyphenyl)thiazol-2-amine
• 英文别名: N-benzyl-4-(4-phenoxyphenyl)-1,3-thiazol-2-amine
• CAS: 1262983-57-2
• 化学式: C₂₂H₁₈N₂OS
• 分子量: 358.464
• InChiKey: UFDRFVVJKYPCKK-UHFFFAOYSA-N

物化性质

• 熔点：
  137-138 °C
• 沸点：
  538.9±60.0 °C(Predicted)
• 密度：
  1.243±0.06 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6
• 重原子数：
  26
• 可旋转键数：
  6
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  62.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2-溴-1-(4-苯氧基苯基)乙酮 、 N-苄基硫脲 在 tert-butylammonium hexafluorophosphate(V) 作用下， 以 甲醇 为溶剂， 反应 0.23h， 以94%的产率得到N-benzyl-4-(4-phenoxyphenyl)thiazol-2-amine
  参考文献：
  名称：

  A Rapid and High-Yielding Synthesis of Thiazoles and Aminothiazoles Using Tetrabutylammonium Salts

  摘要：

  A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetra butylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis data.

  DOI：

  10.3987/com-10-12067

文献信息

• A Rapid and High-Yielding Synthesis of Thiazoles and Aminothiazoles Using Tetrabutylammonium Salts
  作者：Erdal Kocabas、Ahmet Burak Sarıguney、Ahmet Coskun

  DOI：10.3987/com-10-12067

  日期：——

  A convenient method for the synthesis of thiazoles and aminothiazoles by treatment of phenacyl bromides with thioamides/thiourea in the presence of tetra butylammonium hexafluorophosphate (Bu4NPF6) at room temperature was developed. The products having high yields were formed rapidly (within 15 min). The method is simple, rapid and practical, generating thiazole derivatives in excellent isolated yields. The structures of the newly synthesized products were identified by FT-IR, H-1 NMR, C-13 NMR spectroscopy and elemental analysis data.