2-[(二甲基氨基)甲基]四氢萘-1-酮 | 7353-59-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 四氢化萘
• 中文名称: 2-[(二甲基氨基)甲基]四氢萘-1-酮
• 中文别名: 2-((二甲氨基)甲基)-3,4-二氢萘-1(2H)-酮
• 英文名称: 2-dimethylaminomethyl-3,4-dihydro-naphthalen-1-one
• 英文别名: 2-Dimethylaminomethyl-tetralon-(1)；2-Dimethylaminomethyltetralone；2-[(dimethylamino)methyl]-3,4-dihydro-2H-naphthalen-1-one
• CAS: 7353-59-5
• 化学式: C₁₃H₁₇NO
• 分子量: 203.284
• InChiKey: OMCOACHXKJOZMD-UHFFFAOYSA-N

物化性质

• 沸点：
  308.0±11.0 °C(Predicted)
• 密度：
  1.047±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.1
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  2-[(二甲基氨基)甲基]四氢萘-1-酮 在 对苯二酚 作用下， 以 甲苯 为溶剂， 反应 7.0h， 以57%的产率得到spiro<2,3,5,6-tetrahydro-7,8-benzo-1-chroman-2,2'-(1',2',3',4'-tetrahydronaphthalen-1'-one)>
  参考文献：
  名称：

  Synthesis and conversions of the dimer of 2-methylene-5,6-benzocyclohexan-1-one induced by H2S and acids

  摘要：

  DOI：

  10.1007/bf01169632
• 作为产物：
  描述：

  1-(3,4-二氢萘-1-基)吡咯烷 、 N,N-二甲基氯烯亚胺 在 ammonium hydroxide 、 水 作用下， 生成 2-[(二甲基氨基)甲基]四氢萘-1-酮
  参考文献：
  名称：

  Risch, Nikolaus; Esser, Achim, Zeitschrift fur Naturforschung, B: Chemical Sciences, 1989, vol. 44, # 2, p. 208 - 210

  摘要：

  DOI：

文献信息

• A Modified Mannich Reaction Using 1.3-Dioxolane.
  作者：Kazuharu SUMITA、Masayuki KOUMORI、Sachio OHNO

  DOI：10.1248/cpb.42.1676

  日期：——

  Mannich reaction of ketones using 1, 3-dioxolane instead of formaldehyde, paraformaldehyde, or 1, 3, 5-trioxane afforded the corresponding Mannich bases in high yields. Under the same conditions the aminomethylation of aromatics did not proceed but the intramolecular aminomethylation, like a Pictet-Spengler type reaction, proceeded smoothly.

  使用1,3-二恶烷代替甲醛、三聚甲醛或1,3,5-三恶烷进行的酮的Mannich反应，以高产率得到了相应的Mannich碱。在同样的条件下，芳香族的胺甲基化反应并未进行，但类似于Pictet-Spengler类型的分子内胺甲基化反应却顺利进行。
• Amino substituted tetrahydropleiadenes
  申请人：Sandoz, Inc.

  公开号：US03956391A1

  公开（公告）日：1976-05-11

  1,2,3,12a-tetrahydro-1-(substituted-aminomethyl)-7-methylene-7(12H) pleiadenes, e.g., 1,2,3,12a-tetrahydro-1-(dimethylaminomethyl)-7-methylene-7(12H)-pleiadene, prepared by various methods including acid dehydration of the corresponding 1,2,3,12a-tetrahydro-1-(dimethylaminomethyl)-7-methyl-7(12H) -pleiaden-7-ols, are useful as anti-depressants.

  1,2,3,12a-四氢-1-(取代氨甲基)-7-亚甲基-7(12H)普莱阿丁，例如，1,2,3,12a-四氢-1-(二甲胺甲基)-7-亚甲基-7(12H)-普莱阿丁，通过包括酸脱水的各种方法制备，例如对应的1,2,3,12a-四氢-1-(二甲胺甲基)-7-甲基-7(12H)-普莱阿丁-7-醇，可用作抗抑郁药。
• PROCESS FOR PREPARATION OF NORBORNENE DERIVATIVES
  申请人：JX Nippon Oil & Energy Corporation

  公开号：EP2444386A1

  公开（公告）日：2012-04-25

  A method for producing a norbornene derivative, comprising: a first step of forming a Mannich base by reacting a carbonyl compound and an amine compound with each other in an acidic solvent, to thereby obtain a reaction liquid comprising the Mannich base in the acidic solvent, the acidic solvent comprising a formaldehyde derivative and 0.01 mol/L or more of an acid represented by the formula: HX (In the formula, X represents F or the like), the carbonyl compound being represented by any of the following general formulae (1) to (3): [in formulae (1) to (3), R1, R2, R3, R4, R5, and R6 each independently represent a hydrogen atom or the like, and n represents an integer of any of 0 to 4], the amine compound being represented by the following general formula (4): [in the formula (4), R7S each independently represent a linear chain saturated hydrocarbon group having 1 to 20 carbon atoms or the like, and X- represents F- or the like], the Mannich base being represented by any of the following general formulae (5) to (7): [R1, R2, R3, R4, R5, R6, and n in the formulae (5) to (7) have the same meanings as those of R1, R2, R3, R4, R5, R6, and n in the formulae (1) to (3), and R7 and X- in the formulae (5) to (7) have the same meanings as those of R7 and X- in the formula (4)] and a second step of reacting the Mannich base and a diene compound with each other by adding an organic solvent, a base in an amount of 1.0 to 20.0 equivalents to the acid, and the diene compound to the reaction liquid, and then heating the reaction liquid, to thereby form a norbornene derivative, the diene compound being represented by the following general formula (8): [in the formula (8), R8 represents a hydrogen atom or the like], the norbornene derivative being represented by any of the following general formulae (9) to (11): [R1, R2, R3, R4, R5, R6, and n in the formulae (9) to (11) have the same meanings as those of R1, R2, R3, R4, R5, R6, and n in the formulae (1) to (3), and R8 in the formulae (9) to (11) has the same meaning as that of R8 in the formula (8)].

  一种制备去氢莰烯衍生物的方法，包括以下步骤：第一步，在酸性溶剂中使羰基化合物和胺基化合物反应，形成曼尼希碱，从而在酸性溶剂中获得包含曼尼希碱的反应液，所述酸性溶剂包括甲醛衍生物和代表为HX的酸，其中HX中的X代表F或类似物，所述羰基化合物由以下通式（1）至（3）中的任一通式表示：[在通式（1）至（3）中，R1、R2、R3、R4、R5和R6各自独立地代表氢原子或类似物，n代表0至4中的任一整数]，所述胺基化合物由以下通式（4）表示：[在通式（4）中，R7S各自独立地代表具有1至20个碳原子或类似物的线性链饱和碳氢基团，X-代表F-或类似物]，所述曼尼希碱由以下通式（5）至（7）中的任一通式表示：[在通式（5）至（7）中，R1、R2、R3、R4、R5、R6和n的含义与通式（1）至（3）中的R1、R2、R3、R4、R5、R6和n的含义相同，通式（5）至（7）中的R7和X-的含义与通式（4）中的R7和X-的含义相同]；第二步，通过向反应液中加入有机溶剂、相当于酸的1.0至20.0当量的碱和二烯化合物，然后加热反应液，使曼尼希碱与二烯化合物发生反应，从而形成去氢莰烯衍生物，所述二烯化合物由以下通式（8）表示：[在通式（8）中，R8代表氢原子或类似物]，所述去氢莰烯衍生物由以下通式（9）至（11）中的任一通式表示：[在通式（9）至（11）中，R1、R2、R3、R4、R5、R6和n的含义与通式（1）至（3）中的R1、R2、R3、R4、R5、R6和n的含义相同，通式（9）至（11）中的R8的含义与通式（8）中的R8的含义相同]。
• A New Entry to the Synthesis of 1,2-Benzenediol Congeners.
  作者：Yutaka OZAKI、Ikumi OSHIO、Yasue OHSUGA、Shouichi KABURAGI、Zhung-Zhu SUNG、Sang-Won KIM

  DOI：10.1248/cpb.39.1132

  日期：——

  1, 2-Benzenediols were synthesized via 1, 1-bis(ethylthio)-3-cyclohexen-2-one derivatives, which were prepared by condensation of 1, 1-bis(ethylthio)-2-propanone with Mannich bases. Regioselective preparation of their monoethers was also achieved.

  1, 2-苯二醇通过1, 1-双(乙硫基)-3-环己烯-2-酮衍生物合成，这些衍生物是通过1, 1-双(乙硫基)-2-丙酮与曼尼希碱的缩合反应制备的。同时，单醚的位选择性合成也得以实现。
• Cyclic substituted aminomethyl compounds and medicaments comprising these compounds
  申请人：——

  公开号：US20030166708A1

  公开（公告）日：2003-09-04

  Cyclic substituted aminomethyl compounds of general formula IA and IB, methods for production thereof, intermediates in said production methods, a medicament containing at least one of said cyclic substituted aminomethyl compounds, the use of said cyclic substituted aminomethyl compounds for the production of a medicament, pharmaceutical compositions containing said compounds, and methods for the treatment of pain, incontinence, pruritis, tinnitus aurium and/or diarrhea using said pharmaceutical compositions.

  一般式IA和IB的环替代氨甲基化合物，其生产方法，生产方法中的中间体，含有至少一种该环替代氨甲基化合物的药物，利用该环替代氨甲基化合物生产药物，含有该化合物的药物组合物，以及使用该药物组合物治疗疼痛、尿失禁、瘙痒、耳鸣和/或腹泻的方法。