1-(3,4-二氢萘-1-基)吡咯烷 | 7007-34-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 萘
• 中文名称: 1-(3,4-二氢萘-1-基)吡咯烷
• 英文名称: 1-(3,4-dihydro-1-naphthalenyl)pyrrolidine
• 英文别名: 1-(3,4-dihydro-1-naphthyl)pyrrolidine；Pyrrolidine, 1-(3,4-dihydro-1-naphthalenyl)-；1-(3,4-dihydronaphthalen-1-yl)pyrrolidine
• CAS: 7007-34-3
• 化学式: C₁₄H₁₇N
• 分子量: 199.296
• InChiKey: SKQFWLMZKFEKRZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  3.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  1-(3,4-二氢萘-1-基)吡咯烷 在 N-溴代丁二酰亚胺(NBS) 、 偶氮二异丁腈 、 硫酸 、 三乙胺 作用下， 生成 3-phenyl-naphtho[2,1-d]isoxazole
  参考文献：
  名称：

  Bianchi,G.; Frati,E., Gazzetta Chimica Italiana, 1966, vol. 96, p. 559 - 565

  摘要：

  DOI：
• 作为产物：
  描述：

  1,2,3,4-四氢萘 在 chromium(VI) oxide 、 溶剂黄146 作用下， 以 苯 为溶剂， 反应 68.0h， 生成 1-(3,4-二氢萘-1-基)吡咯烷
  参考文献：
  名称：

  Arylmagnesium bromide additions to 1-tetralone-2-acetic acid followed by catalytic hydrogenolysis: stereochemical consequences

  摘要：

  A Stork reaction route (7 --> 1b) was utilized to synthesize 1-tetralone-2-acetic acid methyl ester (1a) from 1-tetralone. Addition of a 2'-(o-methoxyphenyl) magnesium bromide to this ketone followed by palladium-catalyzed hydrogenation of the intermediate cis lactones (2, verified by X-ray crystal structure determination of 2a, Figure 1), afforded predominantly a 1,2-cis tetralin (3) accompanied by smaller yields of the corresponding 1,2-trans tetralin (4). The stereochemical consequences of this reaction sequence was unequivocally established by X-ray crystal structure elucidation of 1,2-cis methyl ester 3b (Figure 2) and 1,2-trans carboxylic acid 4a (Figure 3). Stereochemical assignments for the analogous diastereoisomeric sets 3c-f and 4c-f were obtained by high-field (400-MHz) H-1 and C-13 NMR correlations with the crystal structures. The overall reaction pathway illustrates a useful approach to 1,2-cis-alkylated tetralins and certain sterically hindered 1,2-trans-alkylated tetralins.

  DOI：

  10.1021/jo00018a030

文献信息

• A Method for the Net Contra-thermodynamic Isomerization of Cyclic Trisubstituted Alkenes
  作者：Raphaël F. Guignard、Laurent Petit、Samir Z. Zard

  DOI：10.1021/ol4018744

  日期：2013.8.16

  A simple sequence for the net contra-thermodynamic isomerization of cyclic trisubstituted alkenes is reported consisting of a radical addition of p-chlorothiophenol, followed by oxidation to the sulfoxide and thermal syn-elimination to give the least substituted isomeric cycloalkene.

  为环状三取代烯烃的净禁忌热力学异构化的简单序列报道由自由基加成的p -chlorothiophenol，随后氧化成亚砜和热合成β-消除，得到至少取代的同分异构的环烯烃。
• Method of treatment with and compositions containing condensed pyrroles
  申请人：American Hoechst Corporation

  公开号：US03931407A1

  公开（公告）日：1976-01-06

  Novel N-phenylpyrroles are disclosed that are effective in the treatment of inflammation and pain in mammals and have the formula ##SPC1## Wherein R is hydrogen, alkyl of one to six carbon atoms, thienyl, phenyl or phenyl substituted by halogen, trifluoromethyl, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, alkanoyloxy of one to six carbon atoms, alkanoylamino of one to six carbon atoms, nitro, cyano, hydroxyl, amino or phenyl; R.sub.1 is carboxyl, alkoxycarbonyl of two to seven carbon atoms, carbamoyl, N-alkylcarbamoyl of two to seven carbon atoms, N,N-dialkylcarbamoyl of three to seven carbon atoms, hydroxycarbamoyl or dialkylphosphinylalkoxycarbonyl of four to 10 carbon atoms; R.sub.2 is hydrogen, hydroxyl, mercapto, halogen, trifluoromethyl, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, alkanoyloxy of one to six carbon atoms, alkylthio of one to six carbon atoms, amino, alkylamino of one to six carbon atoms, dialkylamino of two to six carbon atoms, alkanoylamino of one to six carbon atoms, alkanoylthio of one to six carbon atoms, thiocarbamoyloxy, alkylthiocarbamoyloxy of two to six carbon atoms, dialkylthiocarbamoyloxy of three to seven carbon atoms, carbamoylthio, alkylcarbamoylthio of one to six carbon atoms, dialkylcarbamoylthio of two to seven carbon atoms, carbamoylamino, alkylcarbamoylamino of two to six carbon atoms or dialkylcarbamoylamino of three to seven carbon atoms; R.sub.3 is hydrogen, alkanoyl of one to six carbon atoms, or phenyl; X is alkylene of three to five carbon atoms, alkylene of three to five carbon atoms substituted by alkyl or alkoxy of one to six carbon atoms, divinylene, divinylene substituted by alkyl of one to six carbon atoms, ##SPC2## Wherein D is hydrogen, alkyl of one to six carbon atoms, alkoxy of one to six carbon atoms, alkanoyloxy of one to six carbon atoms, alkanoylamino of one to six carbon atoms, halogen, amino, nitro or trifluoromethyl; and n is 1 or 2.

  揭示了对哺乳动物的炎症和疼痛治疗有效的新型N-苯基吡咯类化合物，其化学式为##SPC1##其中R为氢、一至六个碳原子的烷基、噻吩基、苯基或被卤素、三氟甲基、一至六个碳原子的烷基、一至六个碳原子的烷氧基、一至六个碳原子的烷酰氧基、一至六个碳原子的烷酰胺基、硝基、氰基、羟基、氨基或苯基取代的苯基；R.sub.1为羧基、二至七个碳原子的烷氧羰基、氨基甲酰基、二至七个碳原子的N-烷基氨基甲酰基、三至七个碳原子的N,N-二烷基氨基甲酰基、羟基氨基甲酰基或四至十个碳原子的二烷氧羰基磷基；R.sub.2为氢、羟基、巯基、卤素、三氟甲基、一至六个碳原子的烷基、一至六个碳原子的烷氧基、一至六个碳原子的烷酰氧基、一至六个碳原子的烷硫基、氨基、一至六个碳原子的烷基氨基、二至六个碳原子的二烷基氨基、一至六个碳原子的烷酰胺基、一至六个碳原子的烷硫酰基、硫代羰氨氧基、二至六个碳原子的烷硫代羰氨氧基、三至七个碳原子的二烷硫代羰氨氧基、硫代羰氨硫基、一至六个碳原子的烷硫代羰氨硫基、二至七个碳原子的二烷硫代羰氨硫基、羰胺基、二至六个碳原子的烷羰胺基或三至七个碳原子的二烷羰胺基；R.sub.3为氢、一至六个碳原子的烷酰基或苯基；X为三至五个碳原子的烷基、被一至六个碳原子的烷基或烷氧基取代的三至五个碳原子的烷基、二烯基、被一至六个碳原子的烷基取代的二烯基，##SPC2##其中D为氢、一至六个碳原子的烷基、一至六个碳原子的烷氧基、一至六个碳原子的烷酰氧基、一至六个碳原子的烷酰胺基、卤素、氨基、硝基或三氟甲基；n为1或2。
• Dibenz[c,h]acridine receptors for dibutylmalonic acid. Decarboxylative catalytic activity
  作者：MaLuisa Mussons、Cesar Raposo、MaFé de la Torre、Joaquín R. Morán、MaCruz Caballero

  DOI：10.1016/s0040-4020(99)00102-7

  日期：1999.3

  New molecular receptors with dibenz[c,h]acridine skeleton bearing functional groups complementary to malonic acids have been developed. Dibutylmalonic acid is bound in chloroform with Kass values between 102 and 105 M−1 via hydrogen-bonding interactions. The catalytic ability of several of these receptors in the decarboxylative reaction of this diacid has been investigated.

  已经开发了具有带有与丙二酸互补的官能团的二苯并[ c，h ] ac啶骨架的新分子受体。通过氢键相互作用，二丁基丙二酸以10 2至10 5 M -1的Kass值结合在氯仿中。已经研究了这些受体中的几种在该二酸的脱羧反应中的催化能力。
• Carboxyarylindoles as nonsteroidal antiinflammatory agents
  作者：V. Brian Anderson、Marc N. Agnew、Richard C. Allen、Jeffrey C. Wilker、Howard B. Lassman、William J. Novick

  DOI：10.1021/jm00224a023

  日期：1976.2

  An extensive series of carboxyarylindoles has been evaluated for antiinflammatory activity in the carrageenin paw edema assay. The requirements for optimal antiinflammatory activity in this series are relatively specific: a central pyrrole nucleus with (a) a 3-carboxy-4-hydroxyphenyl moiety substituted directly on the nitrogen, (b) a 2-phenyl group (R2) with a substituent of low electronegativity,

  已经在角叉菜胶爪水肿试验中评估了一系列羧芳基吲哚的抗炎活性。此系列中最佳抗炎活性的要求是相对特定的：中心吡咯核具有（a）直接在氮上取代的3-羧基-4-羟基苯基部分，（b）具有取代基的2-苯基（R2）低电负性，（c）在3位（R3）上不存在取代基，和（d）在4,5位（X）上稠合的系统，该系统是亲脂的，准平面的，并且不与N发生空间相互作用-苯基。选择了一种衍生物3-（3-羧基-4-羟基苯基）-2-苯基-4,5-二氢-3H-苯并[e]吲哚（42）进行进一步研究。
• Stereoselectivity of the Radical Reductive Alkylation of Enamines: Importance of the Allylic 1,3-Strain Model
  作者：Serge Schubert、Philippe Renaud、Pierre-Alain Carrupt、Kurt Schenk

  DOI：10.1002/hlca.19930760707

  日期：1993.11.3

  of the cis-disubstituted cycloalkanes. In acyclic systems such as enamines derived from propiophenone and diethyl ketone, moderate to high stereoselectivities were observed in the H-abstraction step. A model based principally on minimization of allylic 1,3-strain (A1,3 strain) was deduced from the experimental results and semi-empirical (AM1) calculations.

  据报道使用Bu 3 SnH作为还原剂向烯胺中自由基加成（方案2和4）。在不同系统中检查了这些反应的非对映选择性（表1和2）。衍生自环状酮（例如环己酮）的烯胺以高非对映选择性被烷基化，并优先形成顺式-二取代的环烷烃。在无环体系中，例如衍生自苯丙酮和二乙基酮的烯胺，在H提取步骤中观察到中等到高的立体选择性。主要基于最小化烯丙基1,3-应变（A 1,3 应变）是根据实验结果和半经验（AM1）计算得出的。